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The protective role of ROS in autoimmune disease.

Hultqvist, Malin LU ; Olsson, Lina LU ; Gelderman, Kyra LU and Holmdahl, Rikard LU (2009) In Trends in Immunology2001-01-01+01:00 30. p.201-208
Abstract
For a long time, reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase (NOX2) complex have been considered harmful mediators of inflammation owing to their highly reactive nature. However, there are an increasing number of findings suggesting that ROS produced by the NOX2 complex are anti-inflammatory and prevent autoimmune responses, thus challenging existing dogma. ROS might not only be produced as a mechanism to eradicate invading pathogens, but rather as a means by which to fine-tune the inflammatory response, depending on when, where and at what amounts they are produced. In this review, we aim to describe the current findings highlighting ROS as regulators of autoimmune inflammation, focusing on autoimmune arthritis.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Immunology2001-01-01+01:00
volume
30
pages
201 - 208
publisher
Elsevier
external identifiers
  • wos:000266431800003
  • pmid:19356981
  • scopus:65449170860
ISSN
1471-4981
DOI
10.1016/j.it.2009.03.004
language
English
LU publication?
yes
id
f5dba947-79cc-447f-bd1d-9ae58192b7be (old id 1392249)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19356981?dopt=Abstract
date added to LUP
2009-05-06 14:01:17
date last changed
2017-11-26 03:49:50
@article{f5dba947-79cc-447f-bd1d-9ae58192b7be,
  abstract     = {For a long time, reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase (NOX2) complex have been considered harmful mediators of inflammation owing to their highly reactive nature. However, there are an increasing number of findings suggesting that ROS produced by the NOX2 complex are anti-inflammatory and prevent autoimmune responses, thus challenging existing dogma. ROS might not only be produced as a mechanism to eradicate invading pathogens, but rather as a means by which to fine-tune the inflammatory response, depending on when, where and at what amounts they are produced. In this review, we aim to describe the current findings highlighting ROS as regulators of autoimmune inflammation, focusing on autoimmune arthritis.},
  author       = {Hultqvist, Malin and Olsson, Lina and Gelderman, Kyra and Holmdahl, Rikard},
  issn         = {1471-4981},
  language     = {eng},
  pages        = {201--208},
  publisher    = {Elsevier},
  series       = {Trends in Immunology2001-01-01+01:00},
  title        = {The protective role of ROS in autoimmune disease.},
  url          = {http://dx.doi.org/10.1016/j.it.2009.03.004},
  volume       = {30},
  year         = {2009},
}