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Evaluation of two pairs of chiral stationary phases: Effects from the length of the achiral spacers

Thunberg, L; Allenmark, S; Friberg, Annika LU ; Ek, Fredrik LU and Frejd, Torbjörn LU (2004) In Chirality 16(9). p.614-624
Abstract
Two pairs of chiral stationary phases (CSPs) with different C-2-symmetric central parts were prepared and evaluated by chromatography of a series of structurally different racemates. Within each pair, the selectors on which the CSPs are based had different lengths of their achiral spacers. The CSPs based on selectors with short spacers showed higher enantioselectivity than the phases incorporating long spacers. On one pair of the phases, a study of the influence from different retention modifiers was performed for a series of benzodiazepinones. This demonstrated the importance of the polymer structure formed from the selectors with different spacer lengths for the enantiodiscriminating ability of the CSPs. (C) 2004 Wiley-Liss, Inc.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
enantioselective liquid chromatography, racemate resolution, selector, synthesis, benzodiazepinones, multiple hydrogen bonding
in
Chirality
volume
16
issue
9
pages
614 - 624
publisher
John Wiley & Sons
external identifiers
  • wos:000224693700007
  • scopus:7044272686
ISSN
1520-636X
DOI
10.1002/chir.20080
language
English
LU publication?
yes
id
890cf220-ea0b-444e-b0f6-8f8fb0ddea15 (old id 139426)
date added to LUP
2007-07-10 14:49:26
date last changed
2017-06-11 03:32:41
@article{890cf220-ea0b-444e-b0f6-8f8fb0ddea15,
  abstract     = {Two pairs of chiral stationary phases (CSPs) with different C-2-symmetric central parts were prepared and evaluated by chromatography of a series of structurally different racemates. Within each pair, the selectors on which the CSPs are based had different lengths of their achiral spacers. The CSPs based on selectors with short spacers showed higher enantioselectivity than the phases incorporating long spacers. On one pair of the phases, a study of the influence from different retention modifiers was performed for a series of benzodiazepinones. This demonstrated the importance of the polymer structure formed from the selectors with different spacer lengths for the enantiodiscriminating ability of the CSPs. (C) 2004 Wiley-Liss, Inc.},
  author       = {Thunberg, L and Allenmark, S and Friberg, Annika and Ek, Fredrik and Frejd, Torbjörn},
  issn         = {1520-636X},
  keyword      = {enantioselective liquid chromatography,racemate resolution,selector,synthesis,benzodiazepinones,multiple hydrogen bonding},
  language     = {eng},
  number       = {9},
  pages        = {614--624},
  publisher    = {John Wiley & Sons},
  series       = {Chirality},
  title        = {Evaluation of two pairs of chiral stationary phases: Effects from the length of the achiral spacers},
  url          = {http://dx.doi.org/10.1002/chir.20080},
  volume       = {16},
  year         = {2004},
}