Advanced

Fibroblasts as matrix modulating cells in asthma and COPD

Nihlberg, Kristian LU (2009) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2009:62.
Abstract
Chronic lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are two lung diseases that are continuously increasing worldwide. Despite extensively research to find curative treatment, no so such therapy exists today. New hypothesis suggests that an aberrant chronic wound healing process takes place which involves both the classical inflammation and more chronic changes of the structural environment where the mesenchymal cell phenotypes such as the fibroblasts play a key role. This phenomenon is defined as airway remodeling and is characterized by a deposition of extracellular matrix (ECM) molecules such as collagens and proteoglycans. Importantly, hitherto available studies have only studied fibroblast from central... (More)
Chronic lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are two lung diseases that are continuously increasing worldwide. Despite extensively research to find curative treatment, no so such therapy exists today. New hypothesis suggests that an aberrant chronic wound healing process takes place which involves both the classical inflammation and more chronic changes of the structural environment where the mesenchymal cell phenotypes such as the fibroblasts play a key role. This phenomenon is defined as airway remodeling and is characterized by a deposition of extracellular matrix (ECM) molecules such as collagens and proteoglycans. Importantly, hitherto available studies have only studied fibroblast from central airways from humans where the role of the fibroblast might be different compared to the distal lung. The aim of the present thesis was to study the different fibroblast phenotypes and their biological role from central and distal localizations from human lung in controls, rhinitis, asthmatics and CODP subjects. Another aim was to investigate the possible origin (circulating progenitor cells) of these cells and thereby highlight the heterogeneity of fibroblast phenotypes resident within the human lung. This investigation demonstrated the novel finding that different fibroblast phenotypes are present in human adult lung. Moreover, they are different in asthma and COPD which suggest disease related fibroblasts that could be of fundamental importance in lung disease. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • PhD Olgart-Höglund, Caroline, Department of Physiology, Karolinska Institutet, Stockholm
organization
publishing date
type
Thesis
publication status
published
subject
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2009:62
pages
131 pages
publisher
Department of Experimental Medical Science, Lund Univeristy
defense location
BMC D15, Klinikgatan 32, Lund
defense date
2009-06-12 09:15
ISSN
1652-8220
ISBN
978-91-86253-50-9
language
English
LU publication?
yes
id
53de1d7a-3968-4905-94f6-dbee15cbc71f (old id 1397355)
date added to LUP
2009-05-20 11:29:46
date last changed
2016-09-19 08:44:47
@phdthesis{53de1d7a-3968-4905-94f6-dbee15cbc71f,
  abstract     = {Chronic lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are two lung diseases that are continuously increasing worldwide. Despite extensively research to find curative treatment, no so such therapy exists today. New hypothesis suggests that an aberrant chronic wound healing process takes place which involves both the classical inflammation and more chronic changes of the structural environment where the mesenchymal cell phenotypes such as the fibroblasts play a key role. This phenomenon is defined as airway remodeling and is characterized by a deposition of extracellular matrix (ECM) molecules such as collagens and proteoglycans. Importantly, hitherto available studies have only studied fibroblast from central airways from humans where the role of the fibroblast might be different compared to the distal lung. The aim of the present thesis was to study the different fibroblast phenotypes and their biological role from central and distal localizations from human lung in controls, rhinitis, asthmatics and CODP subjects. Another aim was to investigate the possible origin (circulating progenitor cells) of these cells and thereby highlight the heterogeneity of fibroblast phenotypes resident within the human lung. This investigation demonstrated the novel finding that different fibroblast phenotypes are present in human adult lung. Moreover, they are different in asthma and COPD which suggest disease related fibroblasts that could be of fundamental importance in lung disease.},
  author       = {Nihlberg, Kristian},
  isbn         = {978-91-86253-50-9},
  issn         = {1652-8220},
  language     = {eng},
  pages        = {131},
  publisher    = {Department of Experimental Medical Science, Lund Univeristy},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series},
  title        = {Fibroblasts as matrix modulating cells in asthma and COPD},
  volume       = {2009:62},
  year         = {2009},
}