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Metabolic alterations in patients with self-inflicted aggressive behaviour

Westling, Sofie LU (2009) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2009:59.
Abstract
Self-inflicted aggressive behaviour is a cross diagnostic phenomenon of major clinical relevance in psychiatric setting. Accumulating evidence speaks for a role of metabolic and immunological factors in aggressive behaviour. The aim of this thesis is to enlighten the role of leptin, insulin, glucagon, glucose and IL-1beta in the context of self-inflicted aggressive behaviour. We used cerebrospinal fluid (CSF-) samples from patients with a recent suicide attempt and plasma samples from a five-hour oral glucose tolerance test (OGTT) in women with deliberate self-harm and healthy controls. The main results from the different papers were:

I. Women with a recent suicide attempt and major depression have decreased CSF- leptin compared... (More)
Self-inflicted aggressive behaviour is a cross diagnostic phenomenon of major clinical relevance in psychiatric setting. Accumulating evidence speaks for a role of metabolic and immunological factors in aggressive behaviour. The aim of this thesis is to enlighten the role of leptin, insulin, glucagon, glucose and IL-1beta in the context of self-inflicted aggressive behaviour. We used cerebrospinal fluid (CSF-) samples from patients with a recent suicide attempt and plasma samples from a five-hour oral glucose tolerance test (OGTT) in women with deliberate self-harm and healthy controls. The main results from the different papers were:

I. Women with a recent suicide attempt and major depression have decreased CSF- leptin compared to those with other diagnoses.

II. Patients using a violent method for attempting suicide have higher CSF-insulin than those using a non-violent method.

III. Women with deliberate self-harm without an eating disorder have low plasma glucose nadir during the OGTT. In those with an eating disorder the low plasma glucose is counteracted by an increased glucagon secretion.

IV. Patients with a recent suicide attempt have increased CSF-IL-1beta compared to healthy controls, and the most pronounced elevations are found in patients with Cluster B personality disorder. Women with deliberate self-harm have increased secretion of IL-1beta during the OGTT compared to healthy controls.

Our findings support the hypothesis of deviant metabolic and immunological components in self-inflicted aggressive behaviour. Future studies are required to further understand the mechanisms of these components, which may open up the development of new treatments for self-inflicted aggression. (Less)
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author
supervisor
opponent
  • MD PhD Ekselius, Lisa, Department of Neuroscience, Psychiatry, Uppsala University, Sweden
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Aggression, insulin, glucose, glucagon, deliberate self-harm, IL-1beta, leptin, suicide attempt.
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2009:59
pages
111 pages
publisher
Lund University, Faculty of Medicine
defense location
Föreläsingssal 01, Kioskg.21, Lund University Hospital, Sweden
defense date
2009-06-13 09:00
ISSN
1652-8220
ISBN
978-91-86253-47-9
language
English
LU publication?
yes
id
6a222972-49cd-422b-a2ac-d08a3752cdc7 (old id 1397365)
date added to LUP
2009-05-20 11:33:22
date last changed
2016-09-19 08:44:49
@phdthesis{6a222972-49cd-422b-a2ac-d08a3752cdc7,
  abstract     = {Self-inflicted aggressive behaviour is a cross diagnostic phenomenon of major clinical relevance in psychiatric setting. Accumulating evidence speaks for a role of metabolic and immunological factors in aggressive behaviour. The aim of this thesis is to enlighten the role of leptin, insulin, glucagon, glucose and IL-1beta in the context of self-inflicted aggressive behaviour. We used cerebrospinal fluid (CSF-) samples from patients with a recent suicide attempt and plasma samples from a five-hour oral glucose tolerance test (OGTT) in women with deliberate self-harm and healthy controls. The main results from the different papers were: <br/><br>
I.	Women with a recent suicide attempt and major depression have decreased CSF- leptin compared to those with other diagnoses.<br/><br>
II.	Patients using a violent method for attempting suicide have higher CSF-insulin than those using a non-violent method.<br/><br>
III.	Women with deliberate self-harm without an eating disorder have low plasma glucose nadir during the OGTT. In those with an eating disorder the low plasma glucose is counteracted by an increased glucagon secretion.<br/><br>
IV.	Patients with a recent suicide attempt have increased CSF-IL-1beta compared to healthy controls, and the most pronounced elevations are found in patients with Cluster B personality disorder. Women with deliberate self-harm have increased secretion of IL-1beta during the OGTT compared to healthy controls. <br/><br>
Our findings support the hypothesis of deviant metabolic and immunological components in self-inflicted aggressive behaviour. Future studies are required to further understand the mechanisms of these components, which may open up the development of new treatments for self-inflicted aggression.},
  author       = {Westling, Sofie},
  isbn         = {978-91-86253-47-9},
  issn         = {1652-8220},
  keyword      = {Aggression,insulin,glucose,glucagon,deliberate self-harm,IL-1beta,leptin,suicide attempt.},
  language     = {eng},
  pages        = {111},
  publisher    = {Lund University, Faculty of Medicine},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series},
  title        = {Metabolic alterations in patients with self-inflicted aggressive behaviour},
  volume       = {2009:59},
  year         = {2009},
}