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Quantitative polar representation of left ventricular myocardial perfusion, function and viability using SPECT and cardiac magnetic resonance: initial results.

Cain, Peter LU ; Ugander, Martin LU ; Palmer, John LU ; Carlsson, Marcus LU ; Heiberg, Einar LU and Arheden, Håkan LU (2005) In Clinical Physiology and Functional Imaging 25(4). p.215-222
Abstract
Background: The clinical management of patients with coronary artery disease (CAD) often involves a complex assessment of the extent and severity of changes in left ventricular (LV) myocardial perfusion, function and viability. We aimed to explore the feasibility of integrative quantitative representation of LV perfusion, function and viability in adjacent polar plots. In order to assess the clinical usefulness of the quantitative methods, we also explored the relationship and determined the agreement between visual scoring and quantitative measurement of regional perfusion and function.



Methods: Ten patients with CAD underwent rest and stress 99mTc-tetrofosmin single photon emission computed tomography (SPECT) and... (More)
Background: The clinical management of patients with coronary artery disease (CAD) often involves a complex assessment of the extent and severity of changes in left ventricular (LV) myocardial perfusion, function and viability. We aimed to explore the feasibility of integrative quantitative representation of LV perfusion, function and viability in adjacent polar plots. In order to assess the clinical usefulness of the quantitative methods, we also explored the relationship and determined the agreement between visual scoring and quantitative measurement of regional perfusion and function.



Methods: Ten patients with CAD underwent rest and stress 99mTc-tetrofosmin single photon emission computed tomography (SPECT) and cardiac magnetic resonance (CMR) imaging. Software was developed in-house for generating polar plots from semi-automatic quantification of rest and stress perfusion from SPECT, function from cine CMR and viability from delayed contrast enhancement (DE) CMR. The agreement between visual assessment and quantification of both perfusion and function was tested by Kendall's coefficient of concordance (W).



Results: Polar plots were created using quantitative data from the semi-automatic analysis of perfusion, function and viability. Kendall's W for agreement between quantitative measurement and visual scoring was 1·0 (P<0·001) for perfusion and 0·85 (P<0·001) for function.



Conclusions: Side-by-side quantitative polar representation of LV perfusion, function and viability is feasible and may aid in the complex assessment of these parameters. The agreement between quantitative measurement and visual scoring was very good for both perfusion and function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging
volume
25
issue
4
pages
215 - 222
publisher
Wiley Online Library
external identifiers
  • wos:000229956800005
  • pmid:15972023
  • scopus:21644465657
ISSN
1475-0961
DOI
10.1111/j.1475-097X.2005.00618.x
language
English
LU publication?
yes
id
3c745cb1-e64b-47da-bda6-edd42b808942 (old id 139848)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15972023&query_hl=140
date added to LUP
2007-07-20 16:30:29
date last changed
2017-10-22 03:55:20
@article{3c745cb1-e64b-47da-bda6-edd42b808942,
  abstract     = {Background: The clinical management of patients with coronary artery disease (CAD) often involves a complex assessment of the extent and severity of changes in left ventricular (LV) myocardial perfusion, function and viability. We aimed to explore the feasibility of integrative quantitative representation of LV perfusion, function and viability in adjacent polar plots. In order to assess the clinical usefulness of the quantitative methods, we also explored the relationship and determined the agreement between visual scoring and quantitative measurement of regional perfusion and function.<br/><br>
<br/><br>
Methods: Ten patients with CAD underwent rest and stress 99mTc-tetrofosmin single photon emission computed tomography (SPECT) and cardiac magnetic resonance (CMR) imaging. Software was developed in-house for generating polar plots from semi-automatic quantification of rest and stress perfusion from SPECT, function from cine CMR and viability from delayed contrast enhancement (DE) CMR. The agreement between visual assessment and quantification of both perfusion and function was tested by Kendall's coefficient of concordance (W).<br/><br>
<br/><br>
Results: Polar plots were created using quantitative data from the semi-automatic analysis of perfusion, function and viability. Kendall's W for agreement between quantitative measurement and visual scoring was 1·0 (P&lt;0·001) for perfusion and 0·85 (P&lt;0·001) for function.<br/><br>
<br/><br>
Conclusions: Side-by-side quantitative polar representation of LV perfusion, function and viability is feasible and may aid in the complex assessment of these parameters. The agreement between quantitative measurement and visual scoring was very good for both perfusion and function.},
  author       = {Cain, Peter and Ugander, Martin and Palmer, John and Carlsson, Marcus and Heiberg, Einar and Arheden, Håkan},
  issn         = {1475-0961},
  language     = {eng},
  number       = {4},
  pages        = {215--222},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {Quantitative polar representation of left ventricular myocardial perfusion, function and viability using SPECT and cardiac magnetic resonance: initial results.},
  url          = {http://dx.doi.org/10.1111/j.1475-097X.2005.00618.x},
  volume       = {25},
  year         = {2005},
}