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The role of collagen antibodies in mediating arthritis

Rowley, Merrill J.; Kutty Selva, Nandakumar LU and Holmdahl, Rikard LU (2008) In Modern Rheumatology 18(5). p.429-441
Abstract
This review examines evidence that rheumatoid arthritis (RA) depends on autoimmunity to articular collagen, and mechanisms whereby autoantibodies to type II collagen contribute to disease development. Three major autoantigenic reactants have been identified in RA; the corresponding autoantibodies are rheumatoid factor (RF), antibodies to citrullinated peptide antigens (ACPA), citrullinated peptides (anti-CCP), and anti-type II collagen (anti-CII). Both RF and ACPA are well-validated and predictive markers of severe erosive RA, but cannot be linked to pathogenesis. By contrast, in various animal species immunized with CII there occurs an erosive inflammatory arthritis resembling that seen in human RA, together with antibodies to CII with an... (More)
This review examines evidence that rheumatoid arthritis (RA) depends on autoimmunity to articular collagen, and mechanisms whereby autoantibodies to type II collagen contribute to disease development. Three major autoantigenic reactants have been identified in RA; the corresponding autoantibodies are rheumatoid factor (RF), antibodies to citrullinated peptide antigens (ACPA), citrullinated peptides (anti-CCP), and anti-type II collagen (anti-CII). Both RF and ACPA are well-validated and predictive markers of severe erosive RA, but cannot be linked to pathogenesis. By contrast, in various animal species immunized with CII there occurs an erosive inflammatory arthritis resembling that seen in human RA, together with antibodies to CII with an epitope specificity similar to that in RA. We discuss the well-known role of immune complexes in the induction of inflammation within the joint, and present recent data showing, additionally, that antibodies to CII cause direct damage to cartilage in vitro. The close resemblances between human RA and collagen-induced arthritis in animals suggest that autoimmunity, and particularly autoantibodies to CII, are important for both the initiation and perpetuation of RA in a dual manner: as contributors to the inflammation associated with immune complex deposition, and as agents with direct degradative effects on cartilage integrity and its repair. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Rheumatoid arthritis, Pathogenic antibodies, induced arthritis, Collagen, Collagen antibodies, Collagen antibody-induced arthritis
in
Modern Rheumatology
volume
18
issue
5
pages
429 - 441
publisher
Springer
external identifiers
  • wos:000264179100001
  • scopus:53549088056
ISSN
1439-7595
DOI
10.1007/s10165-008-0080-x
language
English
LU publication?
yes
id
d03e1783-386f-47b4-81e4-450d2d412fbf (old id 1399342)
date added to LUP
2009-05-28 12:58:22
date last changed
2017-01-01 04:49:15
@article{d03e1783-386f-47b4-81e4-450d2d412fbf,
  abstract     = {This review examines evidence that rheumatoid arthritis (RA) depends on autoimmunity to articular collagen, and mechanisms whereby autoantibodies to type II collagen contribute to disease development. Three major autoantigenic reactants have been identified in RA; the corresponding autoantibodies are rheumatoid factor (RF), antibodies to citrullinated peptide antigens (ACPA), citrullinated peptides (anti-CCP), and anti-type II collagen (anti-CII). Both RF and ACPA are well-validated and predictive markers of severe erosive RA, but cannot be linked to pathogenesis. By contrast, in various animal species immunized with CII there occurs an erosive inflammatory arthritis resembling that seen in human RA, together with antibodies to CII with an epitope specificity similar to that in RA. We discuss the well-known role of immune complexes in the induction of inflammation within the joint, and present recent data showing, additionally, that antibodies to CII cause direct damage to cartilage in vitro. The close resemblances between human RA and collagen-induced arthritis in animals suggest that autoimmunity, and particularly autoantibodies to CII, are important for both the initiation and perpetuation of RA in a dual manner: as contributors to the inflammation associated with immune complex deposition, and as agents with direct degradative effects on cartilage integrity and its repair.},
  author       = {Rowley, Merrill J. and Kutty Selva, Nandakumar and Holmdahl, Rikard},
  issn         = {1439-7595},
  keyword      = {Rheumatoid arthritis,Pathogenic antibodies,induced arthritis,Collagen,Collagen antibodies,Collagen antibody-induced arthritis},
  language     = {eng},
  number       = {5},
  pages        = {429--441},
  publisher    = {Springer},
  series       = {Modern Rheumatology},
  title        = {The role of collagen antibodies in mediating arthritis},
  url          = {http://dx.doi.org/10.1007/s10165-008-0080-x},
  volume       = {18},
  year         = {2008},
}