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Investigating the Effect of Adding Drug (Lidocaine) to a Drug Delivery System Using Small-Angle X-Ray Scattering

Balogh, Joakim LU and Pedersen, Jan Skov (2008) 9th International Conference on Colloid Chemistry, 1997 In Colloids for Nano- and Biotechnology (Progress in Colloid and Polymer Science) 135. p.101-106
Abstract
The effect on a model drug delivery system when adding a drug, lidocaine, has been studied. Temperature and concentration dependence of a nonionic microemulsion with part of the oil, 1 and 10 vol. %, substituted with drug has been investigated. A nonionic oil-in-water microemulsion consisting of CH3(CH2)(11)(OCH2CH2)(5)OH, (C12E5), decane, water and the drug (lidocaine) that has been used to substitute part of the oil was studied. The microscopic differences have been derived from small-angle X-ray scattering (SAXS) data and the results are compared with light scattering data. Using these results together with the macroscopic differences, as observed in the phase diagram (lowering of phase boundaries), between the systems with and without... (More)
The effect on a model drug delivery system when adding a drug, lidocaine, has been studied. Temperature and concentration dependence of a nonionic microemulsion with part of the oil, 1 and 10 vol. %, substituted with drug has been investigated. A nonionic oil-in-water microemulsion consisting of CH3(CH2)(11)(OCH2CH2)(5)OH, (C12E5), decane, water and the drug (lidocaine) that has been used to substitute part of the oil was studied. The microscopic differences have been derived from small-angle X-ray scattering (SAXS) data and the results are compared with light scattering data. Using these results together with the macroscopic differences, as observed in the phase diagram (lowering of phase boundaries), between the systems with and without lidocaine can be explained. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
dependence, Temperature, Nonionic microemulsion, Lidocaine, C12E5, Drug-containing
in
Colloids for Nano- and Biotechnology (Progress in Colloid and Polymer Science)
volume
135
pages
101 - 106
publisher
Springer
conference name
9th International Conference on Colloid Chemistry, 1997
external identifiers
  • wos:000264002200015
  • scopus:62449256851
ISSN
0340-255X
ISBN
978-3-540-85133-2
DOI
10.1007/2882_2008_113
language
English
LU publication?
yes
id
9e9d665d-36da-4b0f-8297-7bb63113c5e3 (old id 1399347)
date added to LUP
2009-05-28 13:04:50
date last changed
2018-01-07 07:38:01
@inproceedings{9e9d665d-36da-4b0f-8297-7bb63113c5e3,
  abstract     = {The effect on a model drug delivery system when adding a drug, lidocaine, has been studied. Temperature and concentration dependence of a nonionic microemulsion with part of the oil, 1 and 10 vol. %, substituted with drug has been investigated. A nonionic oil-in-water microemulsion consisting of CH3(CH2)(11)(OCH2CH2)(5)OH, (C12E5), decane, water and the drug (lidocaine) that has been used to substitute part of the oil was studied. The microscopic differences have been derived from small-angle X-ray scattering (SAXS) data and the results are compared with light scattering data. Using these results together with the macroscopic differences, as observed in the phase diagram (lowering of phase boundaries), between the systems with and without lidocaine can be explained.},
  author       = {Balogh, Joakim and Pedersen, Jan Skov},
  booktitle    = {Colloids for Nano- and Biotechnology (Progress in Colloid and Polymer Science)},
  isbn         = {978-3-540-85133-2},
  issn         = {0340-255X},
  keyword      = {dependence,Temperature,Nonionic microemulsion,Lidocaine,C12E5,Drug-containing},
  language     = {eng},
  pages        = {101--106},
  publisher    = {Springer},
  title        = {Investigating the Effect of Adding Drug (Lidocaine) to a Drug Delivery System Using Small-Angle X-Ray Scattering},
  url          = {http://dx.doi.org/10.1007/2882_2008_113},
  volume       = {135},
  year         = {2008},
}