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Drug Release and Skin Permeation from Lipid Liquid Crystalline Phases

Costa, Fatima LU ; Sparr, Emma LU ; Sousa, J. J. S. and Pais, A. A. C. C. (2008) 9th International Conference on Colloid Chemistry, 1997 In Colloids for Nano- and Biotechnology (Progress in Colloid and Polymer Science) 135. p.119-129
Abstract
We have studied drug release and skin permeation from several different liquid crystalline lipid formulations that may be used to control the respective release rates. We have studied the release and permeation through human skin of a water-soluble and amphiphilic drug, propranolol hydrochloride, from several formulations prepared with monoolein and phytantriol as permeation enhancers and controlled release excipients. Diolein and cineol were added to selected formulations. We observed that viscosity decreases with drug load, wich is compatible with the occurrence of phase changes. Diolein stabilizes the bicontinuous cubic phases leading to an increase in viscosity and sustained release of the drug. The slowest release was found for the... (More)
We have studied drug release and skin permeation from several different liquid crystalline lipid formulations that may be used to control the respective release rates. We have studied the release and permeation through human skin of a water-soluble and amphiphilic drug, propranolol hydrochloride, from several formulations prepared with monoolein and phytantriol as permeation enhancers and controlled release excipients. Diolein and cineol were added to selected formulations. We observed that viscosity decreases with drug load, wich is compatible with the occurrence of phase changes. Diolein stabilizes the bicontinuous cubic phases leading to an increase in viscosity and sustained release of the drug. The slowest release was found for the cubic phases with higher viscosity. Studies on skin permeation showed that these latter formulations also presented lower permeability than the less viscous monoolein lamellar phases. Formulations containing cineol originated higher permeability with higher enhancement ratios. Thus, the various formulations are adapted to different circumstances and delivery routes. While a slow release is usually desired for drug sustained delivery, the transdermal route may require a faster release. Lamellar phases, which are less viscous, are more adapted to transdermal applications. Thus, systems involving lamellar phases of monoolein and cineol are good candidates to be used as skin permeation enhancers for propranolol hydrochloride. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Phytantriol, Monoolein, Lipid liquid crystalline phases, Drug release, Enhancers, Propranolol hydrochloride, Skin permeation
in
Colloids for Nano- and Biotechnology (Progress in Colloid and Polymer Science)
volume
135
pages
119 - 129
publisher
Springer
conference name
9th International Conference on Colloid Chemistry, 1997
external identifiers
  • wos:000264002200017
  • scopus:62449306644
ISSN
0340-255X
ISBN
978-3-540-85133-2
DOI
10.1007/2882_2008_097
language
English
LU publication?
yes
id
d00ec8b8-62ee-4778-8379-305fc6feee0d (old id 1399350)
date added to LUP
2009-05-28 13:07:49
date last changed
2017-01-01 06:29:31
@inproceedings{d00ec8b8-62ee-4778-8379-305fc6feee0d,
  abstract     = {We have studied drug release and skin permeation from several different liquid crystalline lipid formulations that may be used to control the respective release rates. We have studied the release and permeation through human skin of a water-soluble and amphiphilic drug, propranolol hydrochloride, from several formulations prepared with monoolein and phytantriol as permeation enhancers and controlled release excipients. Diolein and cineol were added to selected formulations. We observed that viscosity decreases with drug load, wich is compatible with the occurrence of phase changes. Diolein stabilizes the bicontinuous cubic phases leading to an increase in viscosity and sustained release of the drug. The slowest release was found for the cubic phases with higher viscosity. Studies on skin permeation showed that these latter formulations also presented lower permeability than the less viscous monoolein lamellar phases. Formulations containing cineol originated higher permeability with higher enhancement ratios. Thus, the various formulations are adapted to different circumstances and delivery routes. While a slow release is usually desired for drug sustained delivery, the transdermal route may require a faster release. Lamellar phases, which are less viscous, are more adapted to transdermal applications. Thus, systems involving lamellar phases of monoolein and cineol are good candidates to be used as skin permeation enhancers for propranolol hydrochloride.},
  author       = {Costa, Fatima and Sparr, Emma and Sousa, J. J. S. and Pais, A. A. C. C.},
  booktitle    = {Colloids for Nano- and Biotechnology (Progress in Colloid and Polymer Science)},
  isbn         = {978-3-540-85133-2},
  issn         = {0340-255X},
  keyword      = {Phytantriol,Monoolein,Lipid liquid crystalline phases,Drug release,Enhancers,Propranolol hydrochloride,Skin permeation},
  language     = {eng},
  pages        = {119--129},
  publisher    = {Springer},
  title        = {Drug Release and Skin Permeation from Lipid Liquid Crystalline Phases},
  url          = {http://dx.doi.org/10.1007/2882_2008_097},
  volume       = {135},
  year         = {2008},
}