Advanced

Schizophrenia: From the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers

Stoeber, Gerald; Ben-Shachar, Dorit; Cardon, M.; Falkai, Peter; Fonteh, Alfred N.; Gawlik, Micha; Glenthoj, Birte Y.; Gruenblatt, Edna; Jablensky, Assen and Kim, Yong-Ku, et al. (2009) In World Journal of Biological Psychiatry 10(2). p.127-155
Abstract
Objective. The phenotypic complexity, together with the multifarious nature of the so-called schizophrenic psychoses, limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological... (More)
Objective. The phenotypic complexity, together with the multifarious nature of the so-called schizophrenic psychoses, limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biological markers, schizophrenia, review
in
World Journal of Biological Psychiatry
volume
10
issue
2
pages
127 - 155
publisher
Taylor & Francis
external identifiers
  • wos:000265454900004
  • scopus:67650156832
ISSN
1562-2975
DOI
10.1080/15622970902898980
language
English
LU publication?
yes
id
a0a1a646-1adf-43ea-9ab4-a4c57fe991ba (old id 1399364)
date added to LUP
2009-06-15 15:30:04
date last changed
2017-08-13 03:44:08
@article{a0a1a646-1adf-43ea-9ab4-a4c57fe991ba,
  abstract     = {Objective. The phenotypic complexity, together with the multifarious nature of the so-called schizophrenic psychoses, limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.},
  author       = {Stoeber, Gerald and Ben-Shachar, Dorit and Cardon, M. and Falkai, Peter and Fonteh, Alfred N. and Gawlik, Micha and Glenthoj, Birte Y. and Gruenblatt, Edna and Jablensky, Assen and Kim, Yong-Ku and Kornhuber, Johannes and McNeil, Thomas and Mueller, Norbert and Oranje, Bob and Saito, Toshikazu and Saoud, Mohamed and Schmitt, Andrea and Schwartz, Michal and Thome, Johannes and Uzbekov, Marat and Durany, Nuria and Riederer, Peter},
  issn         = {1562-2975},
  keyword      = {Biological markers,schizophrenia,review},
  language     = {eng},
  number       = {2},
  pages        = {127--155},
  publisher    = {Taylor & Francis},
  series       = {World Journal of Biological Psychiatry},
  title        = {Schizophrenia: From the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers},
  url          = {http://dx.doi.org/10.1080/15622970902898980},
  volume       = {10},
  year         = {2009},
}