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Cancer incidence in the Swedish leather tanning industry: updated findings 1958-99.

Mikoczy, Zoli LU and Hagmar, L (2005) In Occupational and Environmental Medicine 62(7). p.4-461
Abstract (Swedish)
Abstract in Undetermined

Aims: To assess how a 10 year extension of the follow up period affected cancer incidence in the Swedish leather tanning cohort. Methods: A cohort of 2027 tannery workers (of which 482 were women) who had been employed for at least one year between 1900 and 1989 at one of three Swedish leather tanneries, was established. The start of observation varied between 1958 and 1966 for the three plants. Through linkage with the Swedish Cancer Registry, incident cancer cases were recorded up to 1999. Cause specific expected cancer incidence was calculated for 1958-99 based on calendar year, sex, and five year age group specific incidence rates for the counties where the plants had been located. Altogether 56... (More)
Abstract in Undetermined

Aims: To assess how a 10 year extension of the follow up period affected cancer incidence in the Swedish leather tanning cohort. Methods: A cohort of 2027 tannery workers (of which 482 were women) who had been employed for at least one year between 1900 and 1989 at one of three Swedish leather tanneries, was established. The start of observation varied between 1958 and 1966 for the three plants. Through linkage with the Swedish Cancer Registry, incident cancer cases were recorded up to 1999. Cause specific expected cancer incidence was calculated for 1958-99 based on calendar year, sex, and five year age group specific incidence rates for the counties where the plants had been located. Altogether 56 022 person-years at risk were generated. Results: A total of 351 incident cancer cases were observed compared to 302 expected, which resulted in an increased standardised incidence ratio (SIR) of 1.16 (95% CI 1.04 to 1.29). An enhanced risk for prostate cancer was observed (SIR 1.44, 95% CI 1.10 to 1.86), mainly attributable to the later part of the observation period (1990-99). In this updated analysis the previously observed risk excess for soft tissue sarcomas was no longer significant (SIR 2.62, 95% CI 0.96 to 5.70). For multiple myelomas and sinonasal cancer the slight non-significant excesses remained, still based on very few cases. Conclusions: The increased risk for prostate cancer in the present study might be a chance finding, but is noteworthy, since it is in acccordance with the finding of increased SIR for prostate cancer among leather workers in another recent Swedish study. Moreover, excess risks for prostate cancer among farmers have been reported, indicating pesticides as possible causative agents. Leather tanners have also been exposed to pesticides. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Occupational and Environmental Medicine
volume
62
issue
7
pages
4 - 461
publisher
BMJ Publishing Group
external identifiers
  • pmid:15961622
  • wos:000229843000005
  • scopus:21344440805
ISSN
1470-7926
DOI
10.1136/oem.2004.017038
language
English
LU publication?
yes
id
493c7487-b4aa-4208-8d7a-48b6a8209d6d (old id 139976)
alternative location
http://oem.bmj.com/cgi/content/full/62/7/461
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15961622&dopt=Abstract
date added to LUP
2007-07-12 09:57:10
date last changed
2017-08-27 05:11:18
@article{493c7487-b4aa-4208-8d7a-48b6a8209d6d,
  abstract     = {<b>Abstract in Undetermined</b><br/><br>
Aims: To assess how a 10 year extension of the follow up period affected cancer incidence in the Swedish leather tanning cohort. Methods: A cohort of 2027 tannery workers (of which 482 were women) who had been employed for at least one year between 1900 and 1989 at one of three Swedish leather tanneries, was established. The start of observation varied between 1958 and 1966 for the three plants. Through linkage with the Swedish Cancer Registry, incident cancer cases were recorded up to 1999. Cause specific expected cancer incidence was calculated for 1958-99 based on calendar year, sex, and five year age group specific incidence rates for the counties where the plants had been located. Altogether 56 022 person-years at risk were generated. Results: A total of 351 incident cancer cases were observed compared to 302 expected, which resulted in an increased standardised incidence ratio (SIR) of 1.16 (95% CI 1.04 to 1.29). An enhanced risk for prostate cancer was observed (SIR 1.44, 95% CI 1.10 to 1.86), mainly attributable to the later part of the observation period (1990-99). In this updated analysis the previously observed risk excess for soft tissue sarcomas was no longer significant (SIR 2.62, 95% CI 0.96 to 5.70). For multiple myelomas and sinonasal cancer the slight non-significant excesses remained, still based on very few cases. Conclusions: The increased risk for prostate cancer in the present study might be a chance finding, but is noteworthy, since it is in acccordance with the finding of increased SIR for prostate cancer among leather workers in another recent Swedish study. Moreover, excess risks for prostate cancer among farmers have been reported, indicating pesticides as possible causative agents. Leather tanners have also been exposed to pesticides.},
  author       = {Mikoczy, Zoli and Hagmar, L},
  issn         = {1470-7926},
  language     = {eng},
  number       = {7},
  pages        = {4--461},
  publisher    = {BMJ Publishing Group},
  series       = {Occupational and Environmental Medicine},
  title        = {Cancer incidence in the Swedish leather tanning industry: updated findings 1958-99.},
  url          = {http://dx.doi.org/10.1136/oem.2004.017038},
  volume       = {62},
  year         = {2005},
}