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Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging

Ilver, D ; Arnqvist, A ; Ogren, J ; Frick, Inga-Maria LU ; Kersulyte, D ; Incecik, E T ; Berg, D E ; Covacci, A ; Engstrand, L and Boren, T (1998) In Science 279(5349). p.373-377
Abstract
The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science
volume
279
issue
5349
pages
373 - 377
publisher
American Association for the Advancement of Science (AAAS)
external identifiers
  • pmid:9430586
  • scopus:15444357984
ISSN
1095-9203
DOI
10.1126/science.279.5349.373
language
English
LU publication?
yes
id
13b0c457-51d5-4f7e-9bb8-f34e22dcaeec (old id 1113008)
date added to LUP
2016-04-01 16:58:42
date last changed
2025-10-14 10:34:16
@article{13b0c457-51d5-4f7e-9bb8-f34e22dcaeec,
  abstract     = {{The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.}},
  author       = {{Ilver, D and Arnqvist, A and Ogren, J and Frick, Inga-Maria and Kersulyte, D and Incecik, E T and Berg, D E and Covacci, A and Engstrand, L and Boren, T}},
  issn         = {{1095-9203}},
  language     = {{eng}},
  number       = {{5349}},
  pages        = {{373--377}},
  publisher    = {{American Association for the Advancement of Science (AAAS)}},
  series       = {{Science}},
  title        = {{Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging}},
  url          = {{http://dx.doi.org/10.1126/science.279.5349.373}},
  doi          = {{10.1126/science.279.5349.373}},
  volume       = {{279}},
  year         = {{1998}},
}