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Molecular and Serologic Diagnostic Technologies for SARS-CoV-2

Rando, Halie M ; Brueffer, Christian LU orcid ; Lordan, Ronan ; Dattoli, Anna Ada ; Manheim, David ; Meyer, Jesse G ; Mundo, Ariel I ; Perrin, Dimitri ; Mai, David and Wellhausen, Nils , et al. (2022) In arXiv.org
Abstract

The COVID-19 pandemic has presented many challenges that have spurred biotechnological research to address specific problems. Diagnostics is one area where biotechnology has been critical. Diagnostic tests play a vital role in managing a viral threat by facilitating the detection of infected and/or recovered individuals. From the perspective of what information is provided, these tests fall into two major categories, molecular and serological. Molecular diagnostic techniques assay whether a virus is present in a biological sample, thus making it possible to identify individuals who are currently infected. Additionally, when the immune system is exposed to a virus, it responds by producing antibodies specific to the virus. Serological... (More)

The COVID-19 pandemic has presented many challenges that have spurred biotechnological research to address specific problems. Diagnostics is one area where biotechnology has been critical. Diagnostic tests play a vital role in managing a viral threat by facilitating the detection of infected and/or recovered individuals. From the perspective of what information is provided, these tests fall into two major categories, molecular and serological. Molecular diagnostic techniques assay whether a virus is present in a biological sample, thus making it possible to identify individuals who are currently infected. Additionally, when the immune system is exposed to a virus, it responds by producing antibodies specific to the virus. Serological tests make it possible to identify individuals who have mounted an immune response to a virus of interest and therefore facilitate the identification of individuals who have previously encountered the virus. These two categories of tests provide different perspectives valuable to understanding the spread of SARS-CoV-2. Within these categories, different biotechnological approaches offer specific advantages and disadvantages. Here we review the categories of tests developed for the detection of the SARS-CoV-2 virus or antibodies against SARS-CoV-2 and discuss the role of diagnostics in the COVID-19 pandemic.

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author collaboration
organization
publishing date
type
Working paper/Preprint
publication status
published
subject
keywords
SARS-CoV-2, COVID-19, Diagnostics, Serologic Tests, Molecular Diagnostics, Virology
in
arXiv.org
publisher
arXiv.org
external identifiers
  • pmid:35547240
ISSN
2331-8422
DOI
10.48550/arXiv.2204.12598
language
English
LU publication?
yes
id
13c0e617-94fc-4f2c-b25f-2ff337403794
date added to LUP
2022-05-14 13:08:47
date last changed
2023-05-15 09:28:33
@misc{13c0e617-94fc-4f2c-b25f-2ff337403794,
  abstract     = {{<p>The COVID-19 pandemic has presented many challenges that have spurred biotechnological research to address specific problems. Diagnostics is one area where biotechnology has been critical. Diagnostic tests play a vital role in managing a viral threat by facilitating the detection of infected and/or recovered individuals. From the perspective of what information is provided, these tests fall into two major categories, molecular and serological. Molecular diagnostic techniques assay whether a virus is present in a biological sample, thus making it possible to identify individuals who are currently infected. Additionally, when the immune system is exposed to a virus, it responds by producing antibodies specific to the virus. Serological tests make it possible to identify individuals who have mounted an immune response to a virus of interest and therefore facilitate the identification of individuals who have previously encountered the virus. These two categories of tests provide different perspectives valuable to understanding the spread of SARS-CoV-2. Within these categories, different biotechnological approaches offer specific advantages and disadvantages. Here we review the categories of tests developed for the detection of the SARS-CoV-2 virus or antibodies against SARS-CoV-2 and discuss the role of diagnostics in the COVID-19 pandemic.</p>}},
  author       = {{Rando, Halie M and Brueffer, Christian and Lordan, Ronan and Dattoli, Anna Ada and Manheim, David and Meyer, Jesse G and Mundo, Ariel I and Perrin, Dimitri and Mai, David and Wellhausen, Nils and Gitter, Anthony and Greene, Casey S}},
  issn         = {{2331-8422}},
  keywords     = {{SARS-CoV-2; COVID-19; Diagnostics; Serologic Tests; Molecular Diagnostics; Virology}},
  language     = {{eng}},
  month        = {{04}},
  note         = {{Preprint}},
  publisher    = {{arXiv.org}},
  series       = {{arXiv.org}},
  title        = {{Molecular and Serologic Diagnostic Technologies for SARS-CoV-2}},
  url          = {{http://dx.doi.org/10.48550/arXiv.2204.12598}},
  doi          = {{10.48550/arXiv.2204.12598}},
  year         = {{2022}},
}