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Histamine stimulates progesterone synthesis and cyclic adenosine 3',5'-monophosphate accumulation in isolated preovulatory rat follicles

Ahrén, K ; Brännström, M ; Kannisto, P LU ; Owman, C LU ; Sjöberg, N O LU ; Tenenbaum, A and Schmidt, Gunther (1987) In Neuroendocrinology 46(1). p.69-74
Abstract

The effect of histamine on progesterone synthesis and cyclic adenosine 3',5'-monophosphate (cAMP) accumulation was studied in superfused and incubated follicles dissected free from immature rats treated with pregnant mare serum gonadotrophin (PMSG). Histamine, like LH, increased the progesterone synthesis, but to a smaller extent. The H2-antagonist, cimetidine, inhibited completely the histamine-induced progesterone increase while the H1-antagonist, pyrilamine, as well as propranolol and atropine did not affect the initial response but modified its duration. The specific H2-agonist, 4-methylhistamine, but not the H1-agonist, 2-methylhistamine, mimicked the effect of histamine on progesterone synthesis. In the presence of the... (More)

The effect of histamine on progesterone synthesis and cyclic adenosine 3',5'-monophosphate (cAMP) accumulation was studied in superfused and incubated follicles dissected free from immature rats treated with pregnant mare serum gonadotrophin (PMSG). Histamine, like LH, increased the progesterone synthesis, but to a smaller extent. The H2-antagonist, cimetidine, inhibited completely the histamine-induced progesterone increase while the H1-antagonist, pyrilamine, as well as propranolol and atropine did not affect the initial response but modified its duration. The specific H2-agonist, 4-methylhistamine, but not the H1-agonist, 2-methylhistamine, mimicked the effect of histamine on progesterone synthesis. In the presence of the phosphodiesterase inhibitor, IBMX, histamine increased tissue levels of cAMP. These results suggest that histamine stimulates progesterone synthesis via the H2-receptor with cAMP acting as secondary intracellular messenger.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
keywords
1-Methyl-3-isobutylxanthine/pharmacology, Animals, Cyclic AMP/metabolism, Female, Follicular Phase, Gonadotropins, Equine/pharmacology, Histamine/physiology, Ovarian Follicle/drug effects, Progesterone/metabolism, Rats, Rats, Inbred Strains
in
Neuroendocrinology
volume
46
issue
1
pages
6 pages
publisher
Karger
external identifiers
  • pmid:2441309
  • scopus:0023224779
ISSN
0028-3835
DOI
10.1159/000124798
language
English
LU publication?
yes
id
13d064b0-6f8d-4141-866a-a8647f0b1126
date added to LUP
2019-12-03 22:30:25
date last changed
2024-01-02 01:38:19
@article{13d064b0-6f8d-4141-866a-a8647f0b1126,
  abstract     = {{<p>The effect of histamine on progesterone synthesis and cyclic adenosine 3',5'-monophosphate (cAMP) accumulation was studied in superfused and incubated follicles dissected free from immature rats treated with pregnant mare serum gonadotrophin (PMSG). Histamine, like LH, increased the progesterone synthesis, but to a smaller extent. The H2-antagonist, cimetidine, inhibited completely the histamine-induced progesterone increase while the H1-antagonist, pyrilamine, as well as propranolol and atropine did not affect the initial response but modified its duration. The specific H2-agonist, 4-methylhistamine, but not the H1-agonist, 2-methylhistamine, mimicked the effect of histamine on progesterone synthesis. In the presence of the phosphodiesterase inhibitor, IBMX, histamine increased tissue levels of cAMP. These results suggest that histamine stimulates progesterone synthesis via the H2-receptor with cAMP acting as secondary intracellular messenger.</p>}},
  author       = {{Ahrén, K and Brännström, M and Kannisto, P and Owman, C and Sjöberg, N O and Tenenbaum, A and Schmidt, Gunther}},
  issn         = {{0028-3835}},
  keywords     = {{1-Methyl-3-isobutylxanthine/pharmacology; Animals; Cyclic AMP/metabolism; Female; Follicular Phase; Gonadotropins, Equine/pharmacology; Histamine/physiology; Ovarian Follicle/drug effects; Progesterone/metabolism; Rats; Rats, Inbred Strains}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{69--74}},
  publisher    = {{Karger}},
  series       = {{Neuroendocrinology}},
  title        = {{Histamine stimulates progesterone synthesis and cyclic adenosine 3',5'-monophosphate accumulation in isolated preovulatory rat follicles}},
  url          = {{http://dx.doi.org/10.1159/000124798}},
  doi          = {{10.1159/000124798}},
  volume       = {{46}},
  year         = {{1987}},
}