Histamine stimulates progesterone synthesis and cyclic adenosine 3',5'-monophosphate accumulation in isolated preovulatory rat follicles
(1987) In Neuroendocrinology 46(1). p.69-74- Abstract
The effect of histamine on progesterone synthesis and cyclic adenosine 3',5'-monophosphate (cAMP) accumulation was studied in superfused and incubated follicles dissected free from immature rats treated with pregnant mare serum gonadotrophin (PMSG). Histamine, like LH, increased the progesterone synthesis, but to a smaller extent. The H2-antagonist, cimetidine, inhibited completely the histamine-induced progesterone increase while the H1-antagonist, pyrilamine, as well as propranolol and atropine did not affect the initial response but modified its duration. The specific H2-agonist, 4-methylhistamine, but not the H1-agonist, 2-methylhistamine, mimicked the effect of histamine on progesterone synthesis. In the presence of the... (More)
The effect of histamine on progesterone synthesis and cyclic adenosine 3',5'-monophosphate (cAMP) accumulation was studied in superfused and incubated follicles dissected free from immature rats treated with pregnant mare serum gonadotrophin (PMSG). Histamine, like LH, increased the progesterone synthesis, but to a smaller extent. The H2-antagonist, cimetidine, inhibited completely the histamine-induced progesterone increase while the H1-antagonist, pyrilamine, as well as propranolol and atropine did not affect the initial response but modified its duration. The specific H2-agonist, 4-methylhistamine, but not the H1-agonist, 2-methylhistamine, mimicked the effect of histamine on progesterone synthesis. In the presence of the phosphodiesterase inhibitor, IBMX, histamine increased tissue levels of cAMP. These results suggest that histamine stimulates progesterone synthesis via the H2-receptor with cAMP acting as secondary intracellular messenger.
(Less)
- author
- Ahrén, K ; Brännström, M ; Kannisto, P LU ; Owman, C LU ; Sjöberg, N O LU ; Tenenbaum, A and Schmidt, Gunther
- organization
- publishing date
- 1987-06
- type
- Contribution to journal
- publication status
- published
- keywords
- 1-Methyl-3-isobutylxanthine/pharmacology, Animals, Cyclic AMP/metabolism, Female, Follicular Phase, Gonadotropins, Equine/pharmacology, Histamine/physiology, Ovarian Follicle/drug effects, Progesterone/metabolism, Rats, Rats, Inbred Strains
- in
- Neuroendocrinology
- volume
- 46
- issue
- 1
- pages
- 6 pages
- publisher
- Karger
- external identifiers
-
- pmid:2441309
- scopus:0023224779
- ISSN
- 0028-3835
- DOI
- 10.1159/000124798
- language
- English
- LU publication?
- yes
- id
- 13d064b0-6f8d-4141-866a-a8647f0b1126
- date added to LUP
- 2019-12-03 22:30:25
- date last changed
- 2024-01-02 01:38:19
@article{13d064b0-6f8d-4141-866a-a8647f0b1126, abstract = {{<p>The effect of histamine on progesterone synthesis and cyclic adenosine 3',5'-monophosphate (cAMP) accumulation was studied in superfused and incubated follicles dissected free from immature rats treated with pregnant mare serum gonadotrophin (PMSG). Histamine, like LH, increased the progesterone synthesis, but to a smaller extent. The H2-antagonist, cimetidine, inhibited completely the histamine-induced progesterone increase while the H1-antagonist, pyrilamine, as well as propranolol and atropine did not affect the initial response but modified its duration. The specific H2-agonist, 4-methylhistamine, but not the H1-agonist, 2-methylhistamine, mimicked the effect of histamine on progesterone synthesis. In the presence of the phosphodiesterase inhibitor, IBMX, histamine increased tissue levels of cAMP. These results suggest that histamine stimulates progesterone synthesis via the H2-receptor with cAMP acting as secondary intracellular messenger.</p>}}, author = {{Ahrén, K and Brännström, M and Kannisto, P and Owman, C and Sjöberg, N O and Tenenbaum, A and Schmidt, Gunther}}, issn = {{0028-3835}}, keywords = {{1-Methyl-3-isobutylxanthine/pharmacology; Animals; Cyclic AMP/metabolism; Female; Follicular Phase; Gonadotropins, Equine/pharmacology; Histamine/physiology; Ovarian Follicle/drug effects; Progesterone/metabolism; Rats; Rats, Inbred Strains}}, language = {{eng}}, number = {{1}}, pages = {{69--74}}, publisher = {{Karger}}, series = {{Neuroendocrinology}}, title = {{Histamine stimulates progesterone synthesis and cyclic adenosine 3',5'-monophosphate accumulation in isolated preovulatory rat follicles}}, url = {{http://dx.doi.org/10.1159/000124798}}, doi = {{10.1159/000124798}}, volume = {{46}}, year = {{1987}}, }