Efficacy and safety of pelvic organ prolapse surgery with porcine small intestinal submucosa graft implantation
Alexandridis, Vasileios LU
; Teleman, Pia
LU
and Rudnicki, Martin
(2021)
In European Journal of Obstetrics and Gynecology and Reproductive Biology
267.
p.18-22
- Abstract
Objective: The ideal implant material for the surgical repair of pelvic organ prolapse in women is yet to be found. This retrospective study aims to evaluate a porcine small intestinal submucosa (SIS) graft (Surgisis™). Study design: We reviewed the medical records of women that were operated upon for pelvic organ prolapse using implantation of SIS graft and we examined the short-term complications and recurrence rates. Results: A total of 155 surgical procedures were reviewed. SIS graft was placed in the anterior, posterior and middle compartments in 93 (60%), 71 (45.8%) and 13 (8.4%) cases, respectively. At three-month follow-up, 22.6% of anterior graft repairs displayed anatomical recurrence (POP-Q stage ≥ 2), compared to 4.8% of... (More)
Objective: The ideal implant material for the surgical repair of pelvic organ prolapse in women is yet to be found. This retrospective study aims to evaluate a porcine small intestinal submucosa (SIS) graft (Surgisis™). Study design: We reviewed the medical records of women that were operated upon for pelvic organ prolapse using implantation of SIS graft and we examined the short-term complications and recurrence rates. Results: A total of 155 surgical procedures were reviewed. SIS graft was placed in the anterior, posterior and middle compartments in 93 (60%), 71 (45.8%) and 13 (8.4%) cases, respectively. At three-month follow-up, 22.6% of anterior graft repairs displayed anatomical recurrence (POP-Q stage ≥ 2), compared to 4.8% of posterior and none of the middle compartment graft repairs. During the three postoperative months, 56% of the women were recorded with complications, mostly urinary retention (19%) and pain (12%). The incidence of grade III complications was 5.3%. Persistent complications at three months were observed in 28% of all cases. Logistic regression analysis showed that previous prolapse surgery at the same compartment was a significant predictor for recurrence of prolapse after SIS graft application, whereas lower age, smoking and longer duration of surgery were significant predictors for the development of complications. Younger women had higher risk of developing pain postoperatively. Conclusion: Pain and urinary tract symptoms hold a central position in the complications profile of SIS graft-augmented prolapse surgery. The relatively high recurrence rates do not suggest a clear benefit from SIS graft use.
(Less)
- author
- Alexandridis, Vasileios
LU
; Teleman, Pia
LU
and Rudnicki, Martin
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Pelvic organ prolapse, Porcine xenograft bioprosthesis, Postoperative complications, Reconstructive surgical procedures, Recurrence
- in
- European Journal of Obstetrics and Gynecology and Reproductive Biology
- volume
- 267
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:34689022
- scopus:85117571718
- ISSN
- 0301-2115
- DOI
- 10.1016/j.ejogrb.2021.10.011
- project
- The use of implants in surgical treatment of urinary incontinence and pelvic organ prolapse in women
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 The Author(s)
- id
- 13f1f21f-662e-411b-abb3-c8c45f06d650
- date added to LUP
- 2021-11-19 12:23:22
- date last changed
- 2024-06-29 21:44:42
@article{13f1f21f-662e-411b-abb3-c8c45f06d650,
abstract = {{<p>Objective: The ideal implant material for the surgical repair of pelvic organ prolapse in women is yet to be found. This retrospective study aims to evaluate a porcine small intestinal submucosa (SIS) graft (Surgisis™). Study design: We reviewed the medical records of women that were operated upon for pelvic organ prolapse using implantation of SIS graft and we examined the short-term complications and recurrence rates. Results: A total of 155 surgical procedures were reviewed. SIS graft was placed in the anterior, posterior and middle compartments in 93 (60%), 71 (45.8%) and 13 (8.4%) cases, respectively. At three-month follow-up, 22.6% of anterior graft repairs displayed anatomical recurrence (POP-Q stage ≥ 2), compared to 4.8% of posterior and none of the middle compartment graft repairs. During the three postoperative months, 56% of the women were recorded with complications, mostly urinary retention (19%) and pain (12%). The incidence of grade III complications was 5.3%. Persistent complications at three months were observed in 28% of all cases. Logistic regression analysis showed that previous prolapse surgery at the same compartment was a significant predictor for recurrence of prolapse after SIS graft application, whereas lower age, smoking and longer duration of surgery were significant predictors for the development of complications. Younger women had higher risk of developing pain postoperatively. Conclusion: Pain and urinary tract symptoms hold a central position in the complications profile of SIS graft-augmented prolapse surgery. The relatively high recurrence rates do not suggest a clear benefit from SIS graft use.</p>}},
author = {{Alexandridis, Vasileios and Teleman, Pia and Rudnicki, Martin}},
issn = {{0301-2115}},
keywords = {{Pelvic organ prolapse; Porcine xenograft bioprosthesis; Postoperative complications; Reconstructive surgical procedures; Recurrence}},
language = {{eng}},
pages = {{18--22}},
publisher = {{Elsevier}},
series = {{European Journal of Obstetrics and Gynecology and Reproductive Biology}},
title = {{Efficacy and safety of pelvic organ prolapse surgery with porcine small intestinal submucosa graft implantation}},
url = {{http://dx.doi.org/10.1016/j.ejogrb.2021.10.011}},
doi = {{10.1016/j.ejogrb.2021.10.011}},
volume = {{267}},
year = {{2021}},
}