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Mechanisms of hypertension in the cardiometabolic syndrome

Redon, Josep; Cifkova, Renata; Laurent, Stephane; Nilsson, Peter LU ; Narkiewicz, Krzysztof; Erdine, Serap and Mancia, Giuseppe (2009) In Journal of Hypertension 27(3). p.441-451
Abstract
Arterial hypertension is often part of a constellation of anthropometric and metabolic abnormalities that occur simultaneously to a higher degree than would be expected by chance alone, supporting the existence of a discrete disorder, the so-called metabolic syndrome. It is the result of interactions among a large number of interconnected mechanisms, which eventually lead to both an increase in cardiovascular and renal risk, and the development of diabetes. Mechanisms involved in the metabolic syndrome are obesity, insulin resistance, and a constellation of independent factors, which include molecules of hepatic, vascular, and immunologic origin with pro-inflammatory properties. At each of these key points are interactions of demographics,... (More)
Arterial hypertension is often part of a constellation of anthropometric and metabolic abnormalities that occur simultaneously to a higher degree than would be expected by chance alone, supporting the existence of a discrete disorder, the so-called metabolic syndrome. It is the result of interactions among a large number of interconnected mechanisms, which eventually lead to both an increase in cardiovascular and renal risk, and the development of diabetes. Mechanisms involved in the metabolic syndrome are obesity, insulin resistance, and a constellation of independent factors, which include molecules of hepatic, vascular, and immunologic origin with pro-inflammatory properties. At each of these key points are interactions of demographics, lifestyle, genetic factors, and environmental fetal programming. Superimposing upon these are infections or chronic exposure or both to certain drugs that can also make their contribution. Skeletal muscle and the liver, not adipose tissue, are the two key insulin-response tissues involved in maintaining glucose balance, although abnormal insulin action in the adipocytes also plays a role in development of the syndrome. Factors commonly associated with and partly dependent on obesity, insulin resistance, such as overactivity of the sympathetic, stimulation of the renin-angiotensin-aldosterone systems, abnormal renal sodium handling, endothelial dysfunction, and large vessels' alterations, may play a key role in the blood pressure elevation of the syndrome. J Hypertens 27:441-451 (C) 2009 Wolters Kluwer Health/Lippincott Williams & Wilkins. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
damage, large vessels, hypertension, abdominal obesity, endothelium dysfunction, metabolic syndrome
in
Journal of Hypertension
volume
27
issue
3
pages
441 - 451
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000265149200001
  • scopus:67149134992
ISSN
1473-5598
DOI
10.1097/HJH.0b013e32831e13e5
language
English
LU publication?
yes
id
d5389ec4-64dc-47f0-8b4b-2f844a6328a9 (old id 1400217)
date added to LUP
2009-06-15 14:40:51
date last changed
2017-11-19 03:58:44
@article{d5389ec4-64dc-47f0-8b4b-2f844a6328a9,
  abstract     = {Arterial hypertension is often part of a constellation of anthropometric and metabolic abnormalities that occur simultaneously to a higher degree than would be expected by chance alone, supporting the existence of a discrete disorder, the so-called metabolic syndrome. It is the result of interactions among a large number of interconnected mechanisms, which eventually lead to both an increase in cardiovascular and renal risk, and the development of diabetes. Mechanisms involved in the metabolic syndrome are obesity, insulin resistance, and a constellation of independent factors, which include molecules of hepatic, vascular, and immunologic origin with pro-inflammatory properties. At each of these key points are interactions of demographics, lifestyle, genetic factors, and environmental fetal programming. Superimposing upon these are infections or chronic exposure or both to certain drugs that can also make their contribution. Skeletal muscle and the liver, not adipose tissue, are the two key insulin-response tissues involved in maintaining glucose balance, although abnormal insulin action in the adipocytes also plays a role in development of the syndrome. Factors commonly associated with and partly dependent on obesity, insulin resistance, such as overactivity of the sympathetic, stimulation of the renin-angiotensin-aldosterone systems, abnormal renal sodium handling, endothelial dysfunction, and large vessels' alterations, may play a key role in the blood pressure elevation of the syndrome. J Hypertens 27:441-451 (C) 2009 Wolters Kluwer Health/Lippincott Williams & Wilkins.},
  author       = {Redon, Josep and Cifkova, Renata and Laurent, Stephane and Nilsson, Peter and Narkiewicz, Krzysztof and Erdine, Serap and Mancia, Giuseppe},
  issn         = {1473-5598},
  keyword      = {damage,large vessels,hypertension,abdominal obesity,endothelium dysfunction,metabolic syndrome},
  language     = {eng},
  number       = {3},
  pages        = {441--451},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Mechanisms of hypertension in the cardiometabolic syndrome},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e32831e13e5},
  volume       = {27},
  year         = {2009},
}