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Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution

Nilsson, Björn LU ; Johansson, Mikael; Al-Shahrour, Fatima; Carpenter, Anne E. and Ebert, Benjamin L. (2009) In Bioinformatics1998-01-01+01:00 25(8). p.1078-1079
Abstract
Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Bioinformatics1998-01-01+01:00
volume
25
issue
8
pages
1078 - 1079
publisher
Oxford University Press
external identifiers
  • wos:000265094400015
  • scopus:64549088918
ISSN
1367-4803
DOI
10.1093/bioinformatics/btp091
language
English
LU publication?
yes
id
e7b23edb-1ef8-4939-98f5-a96db3a66834 (old id 1400380)
date added to LUP
2009-06-15 14:12:51
date last changed
2017-04-16 03:34:04
@article{e7b23edb-1ef8-4939-98f5-a96db3a66834,
  abstract     = {Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy.},
  author       = {Nilsson, Björn and Johansson, Mikael and Al-Shahrour, Fatima and Carpenter, Anne E. and Ebert, Benjamin L.},
  issn         = {1367-4803},
  language     = {eng},
  number       = {8},
  pages        = {1078--1079},
  publisher    = {Oxford University Press},
  series       = {Bioinformatics1998-01-01+01:00},
  title        = {Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution},
  url          = {http://dx.doi.org/10.1093/bioinformatics/btp091},
  volume       = {25},
  year         = {2009},
}