Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution

Nilsson, Björn LU ; Johansson, Mikael ; Al-Shahrour, Fatima ; Carpenter, Anne E. and Ebert, Benjamin L. (2009) In Bioinformatics 25(8). p.1078-1079
Abstract
Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy.
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Bioinformatics
volume
25
issue
8
pages
1078 - 1079
publisher
Oxford University Press
external identifiers
  • wos:000265094400015
  • scopus:64549088918
  • pmid:19228802
ISSN
1367-4803
DOI
10.1093/bioinformatics/btp091
language
English
LU publication?
yes
id
e7b23edb-1ef8-4939-98f5-a96db3a66834 (old id 1400380)
date added to LUP
2016-04-01 12:07:34
date last changed
2024-10-08 22:36:38
@article{e7b23edb-1ef8-4939-98f5-a96db3a66834,
  abstract     = {{Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy.}},
  author       = {{Nilsson, Björn and Johansson, Mikael and Al-Shahrour, Fatima and Carpenter, Anne E. and Ebert, Benjamin L.}},
  issn         = {{1367-4803}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1078--1079}},
  publisher    = {{Oxford University Press}},
  series       = {{Bioinformatics}},
  title        = {{Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution}},
  url          = {{http://dx.doi.org/10.1093/bioinformatics/btp091}},
  doi          = {{10.1093/bioinformatics/btp091}},
  volume       = {{25}},
  year         = {{2009}},
}