Intestinal lymphocytic epithelioganglionitis: a unique combination of inflammation in bowel dysmotility: a histopathological and immunohistochemical analysis of 28 cases
(2009) In Histopathology 54(5). p.539-549- Abstract
- Intestinal lymphocytic epithelioganglionitis: a unique combination of inflammation in bowel dysmotility: a histopathological and immunohistochemical analysis of 28 cases Visceral inflammatory neuropathies are enteric disorders underlying various forms of bowel dysmotility. The aim was to analyse the microscopic characteristics of a unique combination of intraepithelial lymphocytosis and myenteric ganglioneuritis. Paraffin sections of full-thickness proximal jejunal biopsy specimens from 28 patients, with proven disorders of gastrointestinal motility, were analysed following conventional and immunohistochemical staining. Serial transversal and tangential sectioning visualized large myenteric plexus areas. Between 1993 and 2005, 28 patients... (More)
- Intestinal lymphocytic epithelioganglionitis: a unique combination of inflammation in bowel dysmotility: a histopathological and immunohistochemical analysis of 28 cases Visceral inflammatory neuropathies are enteric disorders underlying various forms of bowel dysmotility. The aim was to analyse the microscopic characteristics of a unique combination of intraepithelial lymphocytosis and myenteric ganglioneuritis. Paraffin sections of full-thickness proximal jejunal biopsy specimens from 28 patients, with proven disorders of gastrointestinal motility, were analysed following conventional and immunohistochemical staining. Serial transversal and tangential sectioning visualized large myenteric plexus areas. Between 1993 and 2005, 28 patients with inflammatory neuropathy (25 female and three male) showed this combination of lymphocytic infiltration. Two of the patients also had coeliac disease. The mean number of intraepithelial CD3+ lymphocytes was 36 per 100 epithelial cells (range 27-68; upper normal limit 25 lymphocytes). There was myenteric ganglionitis of variable severity (mean 4.6 myenteric lymphocytes per ganglion; upper normal limit two lymphocytes) with cytotoxic T-cell predominance. Myenteric neurons showed signs of degeneration and an abnormal immunohistological pattern. Hyperplasia and hypertrophy of Cajal cells were observed. The longitudinal muscle layer was thickened in many cases. A subset of patients with gastrointestinal motility disorders exhibit the combination of intraepithelial lymphocytosis and myenteric ganglionitis in full thickness biopsy specimens of the small bowel. We suggest calling this entity 'intestinal lymphocytic epithelioganglionitis'. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1400625
- author
- Veress, Bela LU ; Nyberg, Bjorn ; Tornblom, Hans and Lindberg, Greger
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- intestinal pseudo-obstruction, inflammation, functional bowel disorders, immunohistochemistry, visceral neuropathy
- in
- Histopathology
- volume
- 54
- issue
- 5
- pages
- 539 - 549
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000265034100003
- pmid:19413636
- scopus:64549162837
- ISSN
- 0309-0167
- DOI
- 10.1111/j.1365-2559.2009.03265.x
- language
- English
- LU publication?
- yes
- id
- eda2a96c-51b3-420a-bfe4-fab86d9c4085 (old id 1400625)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19413636?dopt=Abstract
- date added to LUP
- 2016-04-01 12:16:43
- date last changed
- 2025-04-04 13:56:31
@article{eda2a96c-51b3-420a-bfe4-fab86d9c4085,
abstract = {{Intestinal lymphocytic epithelioganglionitis: a unique combination of inflammation in bowel dysmotility: a histopathological and immunohistochemical analysis of 28 cases Visceral inflammatory neuropathies are enteric disorders underlying various forms of bowel dysmotility. The aim was to analyse the microscopic characteristics of a unique combination of intraepithelial lymphocytosis and myenteric ganglioneuritis. Paraffin sections of full-thickness proximal jejunal biopsy specimens from 28 patients, with proven disorders of gastrointestinal motility, were analysed following conventional and immunohistochemical staining. Serial transversal and tangential sectioning visualized large myenteric plexus areas. Between 1993 and 2005, 28 patients with inflammatory neuropathy (25 female and three male) showed this combination of lymphocytic infiltration. Two of the patients also had coeliac disease. The mean number of intraepithelial CD3+ lymphocytes was 36 per 100 epithelial cells (range 27-68; upper normal limit 25 lymphocytes). There was myenteric ganglionitis of variable severity (mean 4.6 myenteric lymphocytes per ganglion; upper normal limit two lymphocytes) with cytotoxic T-cell predominance. Myenteric neurons showed signs of degeneration and an abnormal immunohistological pattern. Hyperplasia and hypertrophy of Cajal cells were observed. The longitudinal muscle layer was thickened in many cases. A subset of patients with gastrointestinal motility disorders exhibit the combination of intraepithelial lymphocytosis and myenteric ganglionitis in full thickness biopsy specimens of the small bowel. We suggest calling this entity 'intestinal lymphocytic epithelioganglionitis'.}},
author = {{Veress, Bela and Nyberg, Bjorn and Tornblom, Hans and Lindberg, Greger}},
issn = {{0309-0167}},
keywords = {{intestinal pseudo-obstruction; inflammation; functional bowel disorders; immunohistochemistry; visceral neuropathy}},
language = {{eng}},
number = {{5}},
pages = {{539--549}},
publisher = {{Wiley-Blackwell}},
series = {{Histopathology}},
title = {{Intestinal lymphocytic epithelioganglionitis: a unique combination of inflammation in bowel dysmotility: a histopathological and immunohistochemical analysis of 28 cases}},
url = {{http://dx.doi.org/10.1111/j.1365-2559.2009.03265.x}},
doi = {{10.1111/j.1365-2559.2009.03265.x}},
volume = {{54}},
year = {{2009}},
}