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Novel Aspects Pertaining to the Relationship of Waldenstrom's Macroglobulinemia, IgM Monoclonal Gammopathy of Undetermined Significance, Polyclonal Gammopathy, and Hypoglobulinemia

McMaster, Mary L.; Kristinsson, Sigurdur Y.; Turesson, Ingemar LU ; Bjorkholm, Magnus and Landgren, Ola (2009) 5th International Workshop on Waldenstroms Macroglobulinemia In Clinical Lymphoma & Myeloma 9(1). p.19-22
Abstract
Waldenstrom's macroglobulinemia (WM) is associated with a precursor condition, monoclonal gammopathy of undetermined significance (MGUS) of immunoglobulin-M (IgM) type. The etiology of these conditions is unknown. Recent studies at the population level have provided new data regarding familial aggregation of these disorders and other B-cell malignancies. Studies of familial clusters of WM have demonstrated an increased frequency of IgM MGUS compared with the general population and have provided new data suggesting that the phenotypic spectrum might also include polyclonal gammopathy and hypoglobulinemia. While the preponderance of immunoglobulin abnormalities in relatives of WM cases involves IgM, other immunoglobulin types (IgG and IgA)... (More)
Waldenstrom's macroglobulinemia (WM) is associated with a precursor condition, monoclonal gammopathy of undetermined significance (MGUS) of immunoglobulin-M (IgM) type. The etiology of these conditions is unknown. Recent studies at the population level have provided new data regarding familial aggregation of these disorders and other B-cell malignancies. Studies of familial clusters of WM have demonstrated an increased frequency of IgM MGUS compared with the general population and have provided new data suggesting that the phenotypic spectrum might also include polyclonal gammopathy and hypoglobulinemia. While the preponderance of immunoglobulin abnormalities in relatives of WM cases involves IgM, other immunoglobulin types (IgG and IgA) might also be affected. Large collaborative studies are needed to confirm these findings, which present an opportunity to define the earliest lesion(s) in the WM oncogenic pathway. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Precursor disease, IgM, Genetic susceptibility, Hypergammaglobulinemia
in
Clinical Lymphoma & Myeloma
volume
9
issue
1
pages
19 - 22
publisher
CIG Media Group
conference name
5th International Workshop on Waldenstroms Macroglobulinemia
external identifiers
  • wos:000264628200003
  • scopus:67649550658
ISSN
1557-9190
DOI
10.3816/CLM.2009.n.003
language
English
LU publication?
yes
id
0124f190-79a3-402f-8503-38c6a1c8fbbe (old id 1401127)
date added to LUP
2009-06-15 11:31:39
date last changed
2017-01-01 05:51:21
@inproceedings{0124f190-79a3-402f-8503-38c6a1c8fbbe,
  abstract     = {Waldenstrom's macroglobulinemia (WM) is associated with a precursor condition, monoclonal gammopathy of undetermined significance (MGUS) of immunoglobulin-M (IgM) type. The etiology of these conditions is unknown. Recent studies at the population level have provided new data regarding familial aggregation of these disorders and other B-cell malignancies. Studies of familial clusters of WM have demonstrated an increased frequency of IgM MGUS compared with the general population and have provided new data suggesting that the phenotypic spectrum might also include polyclonal gammopathy and hypoglobulinemia. While the preponderance of immunoglobulin abnormalities in relatives of WM cases involves IgM, other immunoglobulin types (IgG and IgA) might also be affected. Large collaborative studies are needed to confirm these findings, which present an opportunity to define the earliest lesion(s) in the WM oncogenic pathway.},
  author       = {McMaster, Mary L. and Kristinsson, Sigurdur Y. and Turesson, Ingemar and Bjorkholm, Magnus and Landgren, Ola},
  booktitle    = {Clinical Lymphoma & Myeloma},
  issn         = {1557-9190},
  keyword      = {Precursor disease,IgM,Genetic susceptibility,Hypergammaglobulinemia},
  language     = {eng},
  number       = {1},
  pages        = {19--22},
  publisher    = {CIG Media Group},
  title        = {Novel Aspects Pertaining to the Relationship of Waldenstrom's Macroglobulinemia, IgM Monoclonal Gammopathy of Undetermined Significance, Polyclonal Gammopathy, and Hypoglobulinemia},
  url          = {http://dx.doi.org/10.3816/CLM.2009.n.003},
  volume       = {9},
  year         = {2009},
}