Novel Aspects Pertaining to the Relationship of Waldenstrom's Macroglobulinemia, IgM Monoclonal Gammopathy of Undetermined Significance, Polyclonal Gammopathy, and Hypoglobulinemia
(2009) 5th International Workshop on Waldenstroms Macroglobulinemia 9(1). p.19-22- Abstract
- Waldenstrom's macroglobulinemia (WM) is associated with a precursor condition, monoclonal gammopathy of undetermined significance (MGUS) of immunoglobulin-M (IgM) type. The etiology of these conditions is unknown. Recent studies at the population level have provided new data regarding familial aggregation of these disorders and other B-cell malignancies. Studies of familial clusters of WM have demonstrated an increased frequency of IgM MGUS compared with the general population and have provided new data suggesting that the phenotypic spectrum might also include polyclonal gammopathy and hypoglobulinemia. While the preponderance of immunoglobulin abnormalities in relatives of WM cases involves IgM, other immunoglobulin types (IgG and IgA)... (More)
- Waldenstrom's macroglobulinemia (WM) is associated with a precursor condition, monoclonal gammopathy of undetermined significance (MGUS) of immunoglobulin-M (IgM) type. The etiology of these conditions is unknown. Recent studies at the population level have provided new data regarding familial aggregation of these disorders and other B-cell malignancies. Studies of familial clusters of WM have demonstrated an increased frequency of IgM MGUS compared with the general population and have provided new data suggesting that the phenotypic spectrum might also include polyclonal gammopathy and hypoglobulinemia. While the preponderance of immunoglobulin abnormalities in relatives of WM cases involves IgM, other immunoglobulin types (IgG and IgA) might also be affected. Large collaborative studies are needed to confirm these findings, which present an opportunity to define the earliest lesion(s) in the WM oncogenic pathway. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1401127
- author
- McMaster, Mary L. ; Kristinsson, Sigurdur Y. ; Turesson, Ingemar LU ; Bjorkholm, Magnus and Landgren, Ola
- organization
- publishing date
- 2009
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Precursor disease, IgM, Genetic susceptibility, Hypergammaglobulinemia
- host publication
- Clinical Lymphoma & Myeloma
- volume
- 9
- issue
- 1
- pages
- 19 - 22
- publisher
- CIG Media Group
- conference name
- 5th International Workshop on Waldenstroms Macroglobulinemia
- conference dates
- 2008-10-15 - 2008-10-19
- external identifiers
-
- wos:000264628200003
- scopus:67649550658
- pmid:19362963
- ISSN
- 1557-9190
- DOI
- 10.3816/CLM.2009.n.003
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
- id
- 0124f190-79a3-402f-8503-38c6a1c8fbbe (old id 1401127)
- date added to LUP
- 2016-04-01 13:44:56
- date last changed
- 2022-04-14 02:54:19
@inproceedings{0124f190-79a3-402f-8503-38c6a1c8fbbe, abstract = {{Waldenstrom's macroglobulinemia (WM) is associated with a precursor condition, monoclonal gammopathy of undetermined significance (MGUS) of immunoglobulin-M (IgM) type. The etiology of these conditions is unknown. Recent studies at the population level have provided new data regarding familial aggregation of these disorders and other B-cell malignancies. Studies of familial clusters of WM have demonstrated an increased frequency of IgM MGUS compared with the general population and have provided new data suggesting that the phenotypic spectrum might also include polyclonal gammopathy and hypoglobulinemia. While the preponderance of immunoglobulin abnormalities in relatives of WM cases involves IgM, other immunoglobulin types (IgG and IgA) might also be affected. Large collaborative studies are needed to confirm these findings, which present an opportunity to define the earliest lesion(s) in the WM oncogenic pathway.}}, author = {{McMaster, Mary L. and Kristinsson, Sigurdur Y. and Turesson, Ingemar and Bjorkholm, Magnus and Landgren, Ola}}, booktitle = {{Clinical Lymphoma & Myeloma}}, issn = {{1557-9190}}, keywords = {{Precursor disease; IgM; Genetic susceptibility; Hypergammaglobulinemia}}, language = {{eng}}, number = {{1}}, pages = {{19--22}}, publisher = {{CIG Media Group}}, title = {{Novel Aspects Pertaining to the Relationship of Waldenstrom's Macroglobulinemia, IgM Monoclonal Gammopathy of Undetermined Significance, Polyclonal Gammopathy, and Hypoglobulinemia}}, url = {{http://dx.doi.org/10.3816/CLM.2009.n.003}}, doi = {{10.3816/CLM.2009.n.003}}, volume = {{9}}, year = {{2009}}, }