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Genetics- and Immune-Related Factors in the Pathogenesis of Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia

Kristinsson, Sigurdur Y.; Koshiol, Jill; Goldin, Lynn R.; Bjorkholm, Magnus; Turesson, Ingemar LU ; Gridley, Gloria; McMaster, Mary L. and Landgren, Ola (2009) 5th International Workshop on Waldenstroms Macroglobulinemia In Clinical Lymphoma & Myeloma 9(1). p.23-26
Abstract
There are emerging data to support a role for genetic and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia. In this article, we review our recently published, large, population-based studies using data from Sweden and from United States veterans and propose mechanisms and pathways underlying our observations. We also discuss future directions for new studies designed to increase our current knowledge and to define underlying biologic mechanisms of our findings. Finally, based on novel insights on this topic, we discuss clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Susceptibility, Rheumatoid arthritis, Lymphoproliferative malignancy, Hepatitis C virus, Autoimmune disease, Familial aggregation
in
Clinical Lymphoma & Myeloma
volume
9
issue
1
pages
23 - 26
publisher
CIG Media Group
conference name
5th International Workshop on Waldenstroms Macroglobulinemia
external identifiers
  • wos:000264628200004
  • scopus:67649519462
ISSN
1557-9190
DOI
10.3816/CLM.2009.n.004
language
English
LU publication?
yes
id
b3dbecb6-4f54-41bc-95e4-bc6406677cad (old id 1401134)
date added to LUP
2009-06-15 11:32:25
date last changed
2017-01-01 06:32:08
@inproceedings{b3dbecb6-4f54-41bc-95e4-bc6406677cad,
  abstract     = {There are emerging data to support a role for genetic and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia. In this article, we review our recently published, large, population-based studies using data from Sweden and from United States veterans and propose mechanisms and pathways underlying our observations. We also discuss future directions for new studies designed to increase our current knowledge and to define underlying biologic mechanisms of our findings. Finally, based on novel insights on this topic, we discuss clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.},
  author       = {Kristinsson, Sigurdur Y. and Koshiol, Jill and Goldin, Lynn R. and Bjorkholm, Magnus and Turesson, Ingemar and Gridley, Gloria and McMaster, Mary L. and Landgren, Ola},
  booktitle    = {Clinical Lymphoma & Myeloma},
  issn         = {1557-9190},
  keyword      = {Susceptibility,Rheumatoid arthritis,Lymphoproliferative malignancy,Hepatitis C virus,Autoimmune disease,Familial aggregation},
  language     = {eng},
  number       = {1},
  pages        = {23--26},
  publisher    = {CIG Media Group},
  title        = {Genetics- and Immune-Related Factors in the Pathogenesis of Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia},
  url          = {http://dx.doi.org/10.3816/CLM.2009.n.004},
  volume       = {9},
  year         = {2009},
}