Advanced

Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex

Mello, Lucilene D.; Ribeiro, Emerson S.; Kubota, Lauro T.; Elmroth, Sofi LU and Pereira, Regina M. S. (2009) In Biometals 22(2). p.385-392
Abstract
The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Transition metal complexes, DNA, Platinum, DNA-metal complex interaction
in
Biometals
volume
22
issue
2
pages
385 - 392
publisher
Springer
external identifiers
  • wos:000264546600020
  • scopus:63149113375
ISSN
0966-0844
DOI
10.1007/s10534-008-9175-2
language
English
LU publication?
yes
id
43e99dcb-8840-4e3a-a770-728a056f5141 (old id 1401629)
date added to LUP
2009-06-15 10:55:13
date last changed
2017-01-01 05:33:15
@article{43e99dcb-8840-4e3a-a770-728a056f5141,
  abstract     = {The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.},
  author       = {Mello, Lucilene D. and Ribeiro, Emerson S. and Kubota, Lauro T. and Elmroth, Sofi and Pereira, Regina M. S.},
  issn         = {0966-0844},
  keyword      = {Transition metal complexes,DNA,Platinum,DNA-metal complex interaction},
  language     = {eng},
  number       = {2},
  pages        = {385--392},
  publisher    = {Springer},
  series       = {Biometals},
  title        = {Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex},
  url          = {http://dx.doi.org/10.1007/s10534-008-9175-2},
  volume       = {22},
  year         = {2009},
}