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Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex

Mello, Lucilene D. ; Ribeiro, Emerson S. ; Kubota, Lauro T. ; Elmroth, Sofi LU and Pereira, Regina M. S. (2009) In BioMetals 22(2). p.385-392
Abstract
The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Transition metal complexes, DNA, Platinum, DNA-metal complex interaction
in
BioMetals
volume
22
issue
2
pages
385 - 392
publisher
Springer
external identifiers
  • wos:000264546600020
  • scopus:63149113375
  • pmid:18982410
ISSN
0966-0844
DOI
10.1007/s10534-008-9175-2
language
English
LU publication?
yes
id
43e99dcb-8840-4e3a-a770-728a056f5141 (old id 1401629)
date added to LUP
2016-04-01 13:14:44
date last changed
2021-06-08 02:27:13
@article{43e99dcb-8840-4e3a-a770-728a056f5141,
  abstract     = {The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.},
  author       = {Mello, Lucilene D. and Ribeiro, Emerson S. and Kubota, Lauro T. and Elmroth, Sofi and Pereira, Regina M. S.},
  issn         = {0966-0844},
  language     = {eng},
  number       = {2},
  pages        = {385--392},
  publisher    = {Springer},
  series       = {BioMetals},
  title        = {Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex},
  url          = {http://dx.doi.org/10.1007/s10534-008-9175-2},
  doi          = {10.1007/s10534-008-9175-2},
  volume       = {22},
  year         = {2009},
}