Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex
(2009) In BioMetals 22(2). p.385-392- Abstract
- The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1401629
- author
- Mello, Lucilene D. ; Ribeiro, Emerson S. ; Kubota, Lauro T. ; Elmroth, Sofi LU and Pereira, Regina M. S.
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Transition metal complexes, DNA, Platinum, DNA-metal complex interaction
- in
- BioMetals
- volume
- 22
- issue
- 2
- pages
- 385 - 392
- publisher
- Springer
- external identifiers
-
- wos:000264546600020
- scopus:63149113375
- pmid:18982410
- ISSN
- 0966-0844
- DOI
- 10.1007/s10534-008-9175-2
- language
- English
- LU publication?
- yes
- id
- 43e99dcb-8840-4e3a-a770-728a056f5141 (old id 1401629)
- date added to LUP
- 2016-04-01 13:14:44
- date last changed
- 2022-04-21 20:35:20
@article{43e99dcb-8840-4e3a-a770-728a056f5141, abstract = {{The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.}}, author = {{Mello, Lucilene D. and Ribeiro, Emerson S. and Kubota, Lauro T. and Elmroth, Sofi and Pereira, Regina M. S.}}, issn = {{0966-0844}}, keywords = {{Transition metal complexes; DNA; Platinum; DNA-metal complex interaction}}, language = {{eng}}, number = {{2}}, pages = {{385--392}}, publisher = {{Springer}}, series = {{BioMetals}}, title = {{Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex}}, url = {{http://dx.doi.org/10.1007/s10534-008-9175-2}}, doi = {{10.1007/s10534-008-9175-2}}, volume = {{22}}, year = {{2009}}, }