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Biochemical tissue-specific injury markers of the heart and brain in postpartum cord blood

Kocylowski, Rafal D.; Dubiel, Mariusz; Gudmundsson, Saemundur LU ; Sieg, Ina; Fritzer, Elfriede; Alkasi, Oezkan; Breborowicz, Gregory H. and von Kaisenberg, Constantin S. (2009) In American Journal of Obstetrics and Gynecology 200(3). p.1-273
Abstract
OBJECTIVE: We sought to establish references ranges and to test the hypothesis that biochemical tissue-specific markers for the heart in umbilical cord blood of newborns with cardiac defects and intrauterine growth restriction (IUGR) are abnormal. STUDY DESIGN: A prospective study was conducted. Serum samples of the umbilical vein (n = 280) and artery (n = 156) from 599 healthy newborns at 37(+0)-42(+0) weeks of gestation were collected. Total creatine kinase (CK), CK-MB heart type (CK-MB), cardiac troponin T (cTnT), myoglobin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and S100 were measured. Reference ranges for each marker were constructed. Concentrations of tissue-specific markers from umbilical cord blood of neonates with... (More)
OBJECTIVE: We sought to establish references ranges and to test the hypothesis that biochemical tissue-specific markers for the heart in umbilical cord blood of newborns with cardiac defects and intrauterine growth restriction (IUGR) are abnormal. STUDY DESIGN: A prospective study was conducted. Serum samples of the umbilical vein (n = 280) and artery (n = 156) from 599 healthy newborns at 37(+0)-42(+0) weeks of gestation were collected. Total creatine kinase (CK), CK-MB heart type (CK-MB), cardiac troponin T (cTnT), myoglobin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and S100 were measured. Reference ranges for each marker were constructed. Concentrations of tissue-specific markers from umbilical cord blood of neonates with cardiac defects (n = 10) and IUGR (n = 41) were plotted against the established reference ranges. RESULTS: Reference ranges for each studied marker were established for both umbilical artery and vein. In fetuses with cardiac defects, both NT-proBNP (4/6 [66%] in the artery, 7/10 [70%] in the vein) and cTnT (2/10 [20%] in the vein) were increased. In fetuses with IUGR in the vein, NT-proBNP (10/41 [24%]) and cTnT (5/41 [12%]) were increased, whereas S100 (9/41 [21%]) was decreased. CONCLUSION: In a subset of neonates with cardiac defects or growth restriction, irrespective of the pH at birth, tissue-specific injury markers for the heart in umbilical cord blood are abnormal. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiac defects, intrauterine growth restriction, umbilical cord blood
in
American Journal of Obstetrics and Gynecology
volume
200
issue
3
pages
1 - 273
publisher
Elsevier
external identifiers
  • wos:000264402700021
  • scopus:60849121064
ISSN
1097-6868
DOI
10.1016/j.ajog.2008.10.009
language
English
LU publication?
yes
id
47b0d4ac-7884-4579-a67f-f83bf27e8156 (old id 1401984)
date added to LUP
2009-05-28 13:54:54
date last changed
2017-08-13 03:36:36
@article{47b0d4ac-7884-4579-a67f-f83bf27e8156,
  abstract     = {OBJECTIVE: We sought to establish references ranges and to test the hypothesis that biochemical tissue-specific markers for the heart in umbilical cord blood of newborns with cardiac defects and intrauterine growth restriction (IUGR) are abnormal. STUDY DESIGN: A prospective study was conducted. Serum samples of the umbilical vein (n = 280) and artery (n = 156) from 599 healthy newborns at 37(+0)-42(+0) weeks of gestation were collected. Total creatine kinase (CK), CK-MB heart type (CK-MB), cardiac troponin T (cTnT), myoglobin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and S100 were measured. Reference ranges for each marker were constructed. Concentrations of tissue-specific markers from umbilical cord blood of neonates with cardiac defects (n = 10) and IUGR (n = 41) were plotted against the established reference ranges. RESULTS: Reference ranges for each studied marker were established for both umbilical artery and vein. In fetuses with cardiac defects, both NT-proBNP (4/6 [66%] in the artery, 7/10 [70%] in the vein) and cTnT (2/10 [20%] in the vein) were increased. In fetuses with IUGR in the vein, NT-proBNP (10/41 [24%]) and cTnT (5/41 [12%]) were increased, whereas S100 (9/41 [21%]) was decreased. CONCLUSION: In a subset of neonates with cardiac defects or growth restriction, irrespective of the pH at birth, tissue-specific injury markers for the heart in umbilical cord blood are abnormal.},
  author       = {Kocylowski, Rafal D. and Dubiel, Mariusz and Gudmundsson, Saemundur and Sieg, Ina and Fritzer, Elfriede and Alkasi, Oezkan and Breborowicz, Gregory H. and von Kaisenberg, Constantin S.},
  issn         = {1097-6868},
  keyword      = {cardiac defects,intrauterine growth restriction,umbilical cord blood},
  language     = {eng},
  number       = {3},
  pages        = {1--273},
  publisher    = {Elsevier},
  series       = {American Journal of Obstetrics and Gynecology},
  title        = {Biochemical tissue-specific injury markers of the heart and brain in postpartum cord blood},
  url          = {http://dx.doi.org/10.1016/j.ajog.2008.10.009},
  volume       = {200},
  year         = {2009},
}