Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet
(2009) In Alimentary pharmacology & therapeutics 29(8). p.811-816- Abstract
- Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status. To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease. In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45-64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status. Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 mu... (More)
- Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status. To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease. In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45-64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status. Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 mu mol/L (7.4-23.0), significantly higher than in matched population controls [10.2 mu mol/L (6.7-22.6) (P < 0.01)]. Following vitamin supplementation, tHcy dropped a median of 34% (P < 0.001), accompanied by significant improvement in well-being (P < 0.01), notably Anxiety (P < 0.05) and Depressed Mood (P < 0.05) for patients with poor well-being. Adults with longstanding coeliac disease taking extra B vitamins for 6 months showed normalized tHcy and significant improvement in general well-being, suggesting that B vitamins should be considered in people advised to follow a gluten-free diet. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1401997
- author
- Hallert, C. ; Svensson, M. ; Tholstrup, J. and Hultberg, Björn LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Alimentary pharmacology & therapeutics
- volume
- 29
- issue
- 8
- pages
- 811 - 816
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000264372400002
- scopus:62849114219
- pmid:19154566
- ISSN
- 0269-2813
- DOI
- 10.1111/j.1365-2036.2009.03945.x
- language
- English
- LU publication?
- yes
- id
- 67487e2d-ae24-45ef-b51f-dae6486c2001 (old id 1401997)
- date added to LUP
- 2016-04-01 14:35:12
- date last changed
- 2022-03-22 00:51:09
@article{67487e2d-ae24-45ef-b51f-dae6486c2001,
abstract = {{Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status. To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease. In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45-64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status. Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 mu mol/L (7.4-23.0), significantly higher than in matched population controls [10.2 mu mol/L (6.7-22.6) (P < 0.01)]. Following vitamin supplementation, tHcy dropped a median of 34% (P < 0.001), accompanied by significant improvement in well-being (P < 0.01), notably Anxiety (P < 0.05) and Depressed Mood (P < 0.05) for patients with poor well-being. Adults with longstanding coeliac disease taking extra B vitamins for 6 months showed normalized tHcy and significant improvement in general well-being, suggesting that B vitamins should be considered in people advised to follow a gluten-free diet.}},
author = {{Hallert, C. and Svensson, M. and Tholstrup, J. and Hultberg, Björn}},
issn = {{0269-2813}},
language = {{eng}},
number = {{8}},
pages = {{811--816}},
publisher = {{Wiley-Blackwell}},
series = {{Alimentary pharmacology & therapeutics}},
title = {{Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet}},
url = {{http://dx.doi.org/10.1111/j.1365-2036.2009.03945.x}},
doi = {{10.1111/j.1365-2036.2009.03945.x}},
volume = {{29}},
year = {{2009}},
}