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Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet

Hallert, C.; Svensson, M.; Tholstrup, J. and Hultberg, Björn LU (2009) In Alimentary Pharmacology & Therapeutics 29(8). p.811-816
Abstract
Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status. To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease. In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45-64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status. Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 mu... (More)
Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status. To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease. In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45-64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status. Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 mu mol/L (7.4-23.0), significantly higher than in matched population controls [10.2 mu mol/L (6.7-22.6) (P < 0.01)]. Following vitamin supplementation, tHcy dropped a median of 34% (P < 0.001), accompanied by significant improvement in well-being (P < 0.01), notably Anxiety (P < 0.05) and Depressed Mood (P < 0.05) for patients with poor well-being. Adults with longstanding coeliac disease taking extra B vitamins for 6 months showed normalized tHcy and significant improvement in general well-being, suggesting that B vitamins should be considered in people advised to follow a gluten-free diet. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alimentary Pharmacology & Therapeutics
volume
29
issue
8
pages
811 - 816
publisher
Wiley-Blackwell
external identifiers
  • wos:000264372400002
  • scopus:62849114219
ISSN
0269-2813
DOI
10.1111/j.1365-2036.2009.03945.x
language
English
LU publication?
yes
id
67487e2d-ae24-45ef-b51f-dae6486c2001 (old id 1401997)
date added to LUP
2009-05-28 14:00:30
date last changed
2017-10-01 04:24:56
@article{67487e2d-ae24-45ef-b51f-dae6486c2001,
  abstract     = {Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status. To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease. In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45-64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status. Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 mu mol/L (7.4-23.0), significantly higher than in matched population controls [10.2 mu mol/L (6.7-22.6) (P &lt; 0.01)]. Following vitamin supplementation, tHcy dropped a median of 34% (P &lt; 0.001), accompanied by significant improvement in well-being (P &lt; 0.01), notably Anxiety (P &lt; 0.05) and Depressed Mood (P &lt; 0.05) for patients with poor well-being. Adults with longstanding coeliac disease taking extra B vitamins for 6 months showed normalized tHcy and significant improvement in general well-being, suggesting that B vitamins should be considered in people advised to follow a gluten-free diet.},
  author       = {Hallert, C. and Svensson, M. and Tholstrup, J. and Hultberg, Björn},
  issn         = {0269-2813},
  language     = {eng},
  number       = {8},
  pages        = {811--816},
  publisher    = {Wiley-Blackwell},
  series       = {Alimentary Pharmacology & Therapeutics},
  title        = {Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet},
  url          = {http://dx.doi.org/10.1111/j.1365-2036.2009.03945.x},
  volume       = {29},
  year         = {2009},
}