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Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease

Fuentes, Romulo; Petersson, Per LU ; Siesser, William B.; Caron, Marc G. and Nicolelis, Miguel A. L. (2009) In Science 323(5921). p.1578-1582
Abstract
Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a highly invasive surgical procedure. We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in both acute pharmacologically induced dopamine-depleted mice and in chronic 6-hydroxydopamine-lesioned rats. The functional recovery was paralleled by a disruption of aberrant low-frequency synchronous corticostriatal oscillations, leading to the emergence of neuronal activity patterns that resemble the state normally preceding spontaneous... (More)
Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a highly invasive surgical procedure. We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in both acute pharmacologically induced dopamine-depleted mice and in chronic 6-hydroxydopamine-lesioned rats. The functional recovery was paralleled by a disruption of aberrant low-frequency synchronous corticostriatal oscillations, leading to the emergence of neuronal activity patterns that resemble the state normally preceding spontaneous initiation of locomotion. We propose that dorsal column stimulation might become an efficient and less invasive alternative for treatment of Parkinson's disease in the future. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science
volume
323
issue
5921
pages
1578 - 1582
publisher
The American Association for the Advancement of Science
external identifiers
  • wos:000264342300031
  • scopus:62849093978
ISSN
1095-9203
DOI
10.1126/science.1164901
language
English
LU publication?
yes
id
92323e37-fa32-4e9e-b8af-96015a4654c2 (old id 1402475)
date added to LUP
2009-06-15 09:42:49
date last changed
2017-11-05 04:07:24
@article{92323e37-fa32-4e9e-b8af-96015a4654c2,
  abstract     = {Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a highly invasive surgical procedure. We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in both acute pharmacologically induced dopamine-depleted mice and in chronic 6-hydroxydopamine-lesioned rats. The functional recovery was paralleled by a disruption of aberrant low-frequency synchronous corticostriatal oscillations, leading to the emergence of neuronal activity patterns that resemble the state normally preceding spontaneous initiation of locomotion. We propose that dorsal column stimulation might become an efficient and less invasive alternative for treatment of Parkinson's disease in the future.},
  author       = {Fuentes, Romulo and Petersson, Per and Siesser, William B. and Caron, Marc G. and Nicolelis, Miguel A. L.},
  issn         = {1095-9203},
  language     = {eng},
  number       = {5921},
  pages        = {1578--1582},
  publisher    = {The American Association for the Advancement of Science},
  series       = {Science},
  title        = {Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease},
  url          = {http://dx.doi.org/10.1126/science.1164901},
  volume       = {323},
  year         = {2009},
}