Perivascular neurotransmitters : Regulation of cerebral blood flow and role in primary headaches
Frederiksen, Simona D. ; Haanes, Kristian A. ; Warfvinge, Karin LU
and Edvinsson, Lars
LU
(2019)
In Journal of Cerebral Blood Flow and Metabolism
39(4).
p.610-632
- Abstract
In order to understand the nature of the relationship between cerebral blood flow (CBF) and primary headaches, we have conducted a literature review with particular emphasis on the role of perivascular neurotransmitters. Primary headaches are in general considered complex polygenic disorders (genetic and environmental influence) with pathophysiological neurovascular alterations. Identified candidate headache genes are associated with neuro- and gliogenesis, vascular development and diseases, and regulation of vascular tone. These findings support a role for the vasculature in primary headache disorders. Moreover, neuronal hyperexcitability and other abnormalities have been observed in primary headaches and related to changes in... (More)
In order to understand the nature of the relationship between cerebral blood flow (CBF) and primary headaches, we have conducted a literature review with particular emphasis on the role of perivascular neurotransmitters. Primary headaches are in general considered complex polygenic disorders (genetic and environmental influence) with pathophysiological neurovascular alterations. Identified candidate headache genes are associated with neuro- and gliogenesis, vascular development and diseases, and regulation of vascular tone. These findings support a role for the vasculature in primary headache disorders. Moreover, neuronal hyperexcitability and other abnormalities have been observed in primary headaches and related to changes in hemodynamic factors. In particular, this relates to migraine aura and spreading depression. During headache attacks, ganglia such as trigeminal and sphenopalatine (located outside the blood-brain barrier) are variably activated and sensitized which gives rise to vasoactive neurotransmitter release. Sympathetic, parasympathetic and sensory nerves to the cerebral vasculature are activated. During migraine attacks, altered CBF has been observed in brain regions such as the somatosensory cortex, brainstem and thalamus. In regulation of CBF, the individual roles of neurotransmitters are partly known, but much needs to be unraveled with respect to headache disorders.
(Less)
- author
- Frederiksen, Simona D.
; Haanes, Kristian A.
; Warfvinge, Karin
LU
and Edvinsson, Lars
LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Blood–brain barrier, cerebral blood flow, migraine, parasympathetic nervous system, sympathetic nervous system
- in
- Journal of Cerebral Blood Flow and Metabolism
- volume
- 39
- issue
- 4
- pages
- 610 - 632
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85045039274
- pmid:29251523
- ISSN
- 0271-678X
- DOI
- 10.1177/0271678X17747188
- language
- English
- LU publication?
- yes
- id
- 14028a5a-ef19-41a0-8e4a-c1e972c75cfe
- date added to LUP
- 2018-04-17 08:32:07
- date last changed
- 2024-06-24 12:59:48
@article{14028a5a-ef19-41a0-8e4a-c1e972c75cfe,
abstract = {{<p>In order to understand the nature of the relationship between cerebral blood flow (CBF) and primary headaches, we have conducted a literature review with particular emphasis on the role of perivascular neurotransmitters. Primary headaches are in general considered complex polygenic disorders (genetic and environmental influence) with pathophysiological neurovascular alterations. Identified candidate headache genes are associated with neuro- and gliogenesis, vascular development and diseases, and regulation of vascular tone. These findings support a role for the vasculature in primary headache disorders. Moreover, neuronal hyperexcitability and other abnormalities have been observed in primary headaches and related to changes in hemodynamic factors. In particular, this relates to migraine aura and spreading depression. During headache attacks, ganglia such as trigeminal and sphenopalatine (located outside the blood-brain barrier) are variably activated and sensitized which gives rise to vasoactive neurotransmitter release. Sympathetic, parasympathetic and sensory nerves to the cerebral vasculature are activated. During migraine attacks, altered CBF has been observed in brain regions such as the somatosensory cortex, brainstem and thalamus. In regulation of CBF, the individual roles of neurotransmitters are partly known, but much needs to be unraveled with respect to headache disorders.</p>}},
author = {{Frederiksen, Simona D. and Haanes, Kristian A. and Warfvinge, Karin and Edvinsson, Lars}},
issn = {{0271-678X}},
keywords = {{Blood–brain barrier; cerebral blood flow; migraine; parasympathetic nervous system; sympathetic nervous system}},
language = {{eng}},
number = {{4}},
pages = {{610--632}},
publisher = {{Nature Publishing Group}},
series = {{Journal of Cerebral Blood Flow and Metabolism}},
title = {{Perivascular neurotransmitters : Regulation of cerebral blood flow and role in primary headaches}},
url = {{http://dx.doi.org/10.1177/0271678X17747188}},
doi = {{10.1177/0271678X17747188}},
volume = {{39}},
year = {{2019}},
}