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Elevated intracranial pressure or subarachnoid blood responsible for reduction in cerebral blood flow after SAH

Ansar, Saema LU and Edvinsson, Lars LU (2008) 9th International Conference on Cerebral Vasospasm 104. p.231-233
Abstract
Background. The pathogenesis of cerebral ischemia after subarachnoid hemorrhage (SAH) still remains elusive. The purpose of the present study was to examine whether it is the change in intracranial pressure (ICP) or the extravasated blood that is responsible for cerebral ischemia and cerebral vasoconstriction observed following SAH. Method. Three groups of animals were studied; (1) cisternal injection of 250 mu l blood (SAH), (2) injection of 250 mu l NaCl (saline) or (3) same procedure in every detail but no fluid injection (sham). Two days after the treatment, an autoradiographic technique was used to investigate the cerebral blood flow (CBF). Findings. Both SAH (blood+ ICP) and saline injection (ICP only) resulted in significantly... (More)
Background. The pathogenesis of cerebral ischemia after subarachnoid hemorrhage (SAH) still remains elusive. The purpose of the present study was to examine whether it is the change in intracranial pressure (ICP) or the extravasated blood that is responsible for cerebral ischemia and cerebral vasoconstriction observed following SAH. Method. Three groups of animals were studied; (1) cisternal injection of 250 mu l blood (SAH), (2) injection of 250 mu l NaCl (saline) or (3) same procedure in every detail but no fluid injection (sham). Two days after the treatment, an autoradiographic technique was used to investigate the cerebral blood flow (CBF). Findings. Both SAH (blood+ ICP) and saline injection (ICP only) resulted in significantly reduced regional and global CBF after as compared to sham/control. Conclusions. This study revealed that both the elevation of ICP and A Subarachnoid blood per se contribute approximately equally to the SAH induced effects. (Less)
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author
and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
cerebral blood flow cerebral ischemia, intracranial pressure, subarachnoid hemorrhage
host publication
Cerebral Vasospasm: New Strategies in Research and Treatment
volume
104
pages
231 - 233
publisher
Springer
conference name
9th International Conference on Cerebral Vasospasm
conference location
Istanbul, Turkey
conference dates
2006-06-27 - 2006-06-30
external identifiers
  • wos:000256013000045
  • scopus:77957580469
ISSN
0065-1419
ISBN
978-3-211-75717-8
DOI
10.1007/978-3-211-75718-5_45
language
English
LU publication?
yes
id
99a5b58d-858f-4638-81fc-b7846f9112f7 (old id 1407185)
date added to LUP
2016-04-01 14:51:59
date last changed
2024-10-10 22:43:45
@inproceedings{99a5b58d-858f-4638-81fc-b7846f9112f7,
  abstract     = {{Background. The pathogenesis of cerebral ischemia after subarachnoid hemorrhage (SAH) still remains elusive. The purpose of the present study was to examine whether it is the change in intracranial pressure (ICP) or the extravasated blood that is responsible for cerebral ischemia and cerebral vasoconstriction observed following SAH. Method. Three groups of animals were studied; (1) cisternal injection of 250 mu l blood (SAH), (2) injection of 250 mu l NaCl (saline) or (3) same procedure in every detail but no fluid injection (sham). Two days after the treatment, an autoradiographic technique was used to investigate the cerebral blood flow (CBF). Findings. Both SAH (blood+ ICP) and saline injection (ICP only) resulted in significantly reduced regional and global CBF after as compared to sham/control. Conclusions. This study revealed that both the elevation of ICP and A Subarachnoid blood per se contribute approximately equally to the SAH induced effects.}},
  author       = {{Ansar, Saema and Edvinsson, Lars}},
  booktitle    = {{Cerebral Vasospasm: New Strategies in Research and Treatment}},
  isbn         = {{978-3-211-75717-8}},
  issn         = {{0065-1419}},
  keywords     = {{cerebral blood flow cerebral ischemia; intracranial pressure; subarachnoid hemorrhage}},
  language     = {{eng}},
  pages        = {{231--233}},
  publisher    = {{Springer}},
  title        = {{Elevated intracranial pressure or subarachnoid blood responsible for reduction in cerebral blood flow after SAH}},
  url          = {{http://dx.doi.org/10.1007/978-3-211-75718-5_45}},
  doi          = {{10.1007/978-3-211-75718-5_45}},
  volume       = {{104}},
  year         = {{2008}},
}