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An electrical impedance model for deep brain stimulation of Parkinson's disease

Blad, Börje LU (2007) 13th International Conference on Electrical Bioimpedance/8th Conference on Electrical Impedance Tomography In 13th International Conference on Electrical Bioimpedance and the 8th Conference on Electrical Impedance Tomography 17. p.60-61
Abstract
Deep brain stimulation is an accepted technique for the treatment of Parkinson's disease. Deep brain stimulation affects the electrical functions of neurons and several explanations are available to describe this treatment modality. Such as depolarization blockade, synaptic inhibition, synaptic depression and stimulation induced modulation of pathological network activity. An electrical impedance model of the treatment area around the electrodes in the brain is determined to further increase the understanding of deep brain stimulation. This model shows the contact impedance between the electrodes and the tissue, the extra cellular resistance, the intra cellular resistance of the neurons and the effect of deep brain stimulation on the... (More)
Deep brain stimulation is an accepted technique for the treatment of Parkinson's disease. Deep brain stimulation affects the electrical functions of neurons and several explanations are available to describe this treatment modality. Such as depolarization blockade, synaptic inhibition, synaptic depression and stimulation induced modulation of pathological network activity. An electrical impedance model of the treatment area around the electrodes in the brain is determined to further increase the understanding of deep brain stimulation. This model shows the contact impedance between the electrodes and the tissue, the extra cellular resistance, the intra cellular resistance of the neurons and the effect of deep brain stimulation on the treated area in the brain, which in this case is stimulation of the sub thalamic nucleus. The generated electrical field near the electrodes is high enough to perform an electropermeabilization of the cell membranes. This is modelled as a cell membrane capacitance in series with a resistance. The resistance is the consequence of electropermeabilization of the cell membranes. Many observed parameters that occur during deep brain stimulation is reduced tremor activity, influence on speech, the same effect as a lesion, increased axon activity downstream, followed by durations of nerve silence. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
electropermeabilization, electrical impedance model, deep brain stimulation
in
13th International Conference on Electrical Bioimpedance and the 8th Conference on Electrical Impedance Tomography
volume
17
pages
60 - 61
publisher
Springer
conference name
13th International Conference on Electrical Bioimpedance/8th Conference on Electrical Impedance Tomography
external identifiers
  • wos:000254221700015
ISSN
1680-0737
ISBN
978-3-540-73840-4
DOI
10.1007/978-3-540-73841-1_18
language
English
LU publication?
yes
id
e42167a8-0bb7-4778-b4bb-b8aca4c0a1b6 (old id 1407412)
date added to LUP
2009-06-02 13:54:28
date last changed
2016-04-16 04:02:32
@inproceedings{e42167a8-0bb7-4778-b4bb-b8aca4c0a1b6,
  abstract     = {Deep brain stimulation is an accepted technique for the treatment of Parkinson's disease. Deep brain stimulation affects the electrical functions of neurons and several explanations are available to describe this treatment modality. Such as depolarization blockade, synaptic inhibition, synaptic depression and stimulation induced modulation of pathological network activity. An electrical impedance model of the treatment area around the electrodes in the brain is determined to further increase the understanding of deep brain stimulation. This model shows the contact impedance between the electrodes and the tissue, the extra cellular resistance, the intra cellular resistance of the neurons and the effect of deep brain stimulation on the treated area in the brain, which in this case is stimulation of the sub thalamic nucleus. The generated electrical field near the electrodes is high enough to perform an electropermeabilization of the cell membranes. This is modelled as a cell membrane capacitance in series with a resistance. The resistance is the consequence of electropermeabilization of the cell membranes. Many observed parameters that occur during deep brain stimulation is reduced tremor activity, influence on speech, the same effect as a lesion, increased axon activity downstream, followed by durations of nerve silence.},
  author       = {Blad, Börje},
  booktitle    = {13th International Conference on Electrical Bioimpedance and the 8th Conference on Electrical Impedance Tomography},
  isbn         = {978-3-540-73840-4},
  issn         = {1680-0737},
  keyword      = {electropermeabilization,electrical impedance model,deep brain stimulation},
  language     = {eng},
  pages        = {60--61},
  publisher    = {Springer},
  title        = {An electrical impedance model for deep brain stimulation of Parkinson's disease},
  url          = {http://dx.doi.org/10.1007/978-3-540-73841-1_18},
  volume       = {17},
  year         = {2007},
}