Advanced

Thermoresponsive properties of sugar sensitive copolymer of N-isopropylacrylamide and 3-(acrylamido)phenylboronic acid

Shiomori, Koichiro LU ; Ivanov, Alexander LU ; Galaev, Igor LU ; Kawano, Y and Mattiasson, Bo LU (2004) In Macromolecular Chemistry and Physics 205(1). p.27-34
Abstract
The copolymer of N-isopropylacrylamide and 3-(acrylamido)phenylboronic acid (82:18, (M) over bar (n)=47000 g. mol(-1)) was prepared by free radical polymerization. The copolymer showed typical thermal precipitation behavior in aqueous solutions, its precipitation temperature (T-P) being increased from 23 to 32degreesC by increasing the pH from 6.5 to 9.7, because of ionization of the phenylboronate units. The pK(a) was evaluated as 8.9+/-0.1 from the effect of pH on T-P. At pH>9, i.e., in the anionic form of the copolymer, T-P was affected by a very low concentration of glucose (5.6 muM, DeltaT(P)=1-1.5degreesC), because of complex formation with a high binding constant. At a higher concentration of polyols (560 muM, pH>8) the... (More)
The copolymer of N-isopropylacrylamide and 3-(acrylamido)phenylboronic acid (82:18, (M) over bar (n)=47000 g. mol(-1)) was prepared by free radical polymerization. The copolymer showed typical thermal precipitation behavior in aqueous solutions, its precipitation temperature (T-P) being increased from 23 to 32degreesC by increasing the pH from 6.5 to 9.7, because of ionization of the phenylboronate units. The pK(a) was evaluated as 8.9+/-0.1 from the effect of pH on T-P. At pH>9, i.e., in the anionic form of the copolymer, T-P was affected by a very low concentration of glucose (5.6 muM, DeltaT(P)=1-1.5degreesC), because of complex formation with a high binding constant. At a higher concentration of polyols (560 muM, pH>8) the increase of T-P was maximal for the copolymer complexes with fructose (7-10degreesC) and decreased in the order: fructose>glucoseapproximate tomannitol>pentaerythritol>galactose>Tris>glycerol. Di- and oligosaccharides (lactose, sucrose, and dextran) caused a slight increase of T-P at pH 7.5-8.7 while no effect was observed at pH>9. Isothermal dissolution of the copolymer suspension in water (27degreesC, pH 8.5) was possible in the. presence of fructose or mannitol but required higher concentrations (1.4-3.6 x 10(3) muM) as compared to those which enabled the shift of T-P in the soluble copolymer. The dissolution rate increased with fructose concentrations. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Macromolecular Chemistry and Physics
volume
205
issue
1
pages
27 - 34
publisher
John Wiley & Sons
external identifiers
  • wos:000188800100003
  • scopus:1142298877
ISSN
1521-3935
DOI
10.1002/macp.200300019
language
English
LU publication?
yes
id
acb2296a-d181-48c3-a520-7160713eb583 (old id 140743)
date added to LUP
2007-07-03 08:46:03
date last changed
2017-11-19 03:35:14
@article{acb2296a-d181-48c3-a520-7160713eb583,
  abstract     = {The copolymer of N-isopropylacrylamide and 3-(acrylamido)phenylboronic acid (82:18, (M) over bar (n)=47000 g. mol(-1)) was prepared by free radical polymerization. The copolymer showed typical thermal precipitation behavior in aqueous solutions, its precipitation temperature (T-P) being increased from 23 to 32degreesC by increasing the pH from 6.5 to 9.7, because of ionization of the phenylboronate units. The pK(a) was evaluated as 8.9+/-0.1 from the effect of pH on T-P. At pH>9, i.e., in the anionic form of the copolymer, T-P was affected by a very low concentration of glucose (5.6 muM, DeltaT(P)=1-1.5degreesC), because of complex formation with a high binding constant. At a higher concentration of polyols (560 muM, pH>8) the increase of T-P was maximal for the copolymer complexes with fructose (7-10degreesC) and decreased in the order: fructose>glucoseapproximate tomannitol>pentaerythritol>galactose>Tris>glycerol. Di- and oligosaccharides (lactose, sucrose, and dextran) caused a slight increase of T-P at pH 7.5-8.7 while no effect was observed at pH>9. Isothermal dissolution of the copolymer suspension in water (27degreesC, pH 8.5) was possible in the. presence of fructose or mannitol but required higher concentrations (1.4-3.6 x 10(3) muM) as compared to those which enabled the shift of T-P in the soluble copolymer. The dissolution rate increased with fructose concentrations.},
  author       = {Shiomori, Koichiro and Ivanov, Alexander and Galaev, Igor and Kawano, Y and Mattiasson, Bo},
  issn         = {1521-3935},
  language     = {eng},
  number       = {1},
  pages        = {27--34},
  publisher    = {John Wiley & Sons},
  series       = {Macromolecular Chemistry and Physics},
  title        = {Thermoresponsive properties of sugar sensitive copolymer of N-isopropylacrylamide and 3-(acrylamido)phenylboronic acid},
  url          = {http://dx.doi.org/10.1002/macp.200300019},
  volume       = {205},
  year         = {2004},
}