Analysis of a digital clock for molecular computing
(2007) American Control Conference, 2007 p.2678-2682- Abstract
- The control of synthetic genetic regulatory networks is an emerging engineering challenge. In this study, we propose a new synthetic genetic network that behaves as a digital clock, producing square waveform oscillations. We analyze two models of the network: a deterministic model based on Michaelis-Menten kinetics, as well as a stochastic model based on the Gillespie algorithm. Both models predict regions of oscillatory behavior; the deterministic model provides insight into the conditions required to produce the oscillating clock-like behavior, while the stochastic model is truer to natural dynamics. Intracellular stochasticity is seen to contribute phase noise to the oscillator, and we propose improvements for the network and discuss... (More)
- The control of synthetic genetic regulatory networks is an emerging engineering challenge. In this study, we propose a new synthetic genetic network that behaves as a digital clock, producing square waveform oscillations. We analyze two models of the network: a deterministic model based on Michaelis-Menten kinetics, as well as a stochastic model based on the Gillespie algorithm. Both models predict regions of oscillatory behavior; the deterministic model provides insight into the conditions required to produce the oscillating clock-like behavior, while the stochastic model is truer to natural dynamics. Intracellular stochasticity is seen to contribute phase noise to the oscillator, and we propose improvements for the network and discuss the conceptual foundations of these improvements. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1407732
- author
- Ugander, Johan LU ; Dunlop, Mary J. and Murray, Richard M.
- organization
- publishing date
- 2007
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- American Control Conference, 2007, vols 1-13
- pages
- 2678 - 2682
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- conference name
- American Control Conference, 2007
- conference location
- New York, NY, United States
- conference dates
- 2007-07-11 - 2007-07-13
- external identifiers
-
- wos:000252258801210
- scopus:46449092551
- ISSN
- 0743-1619
- ISBN
- 1-4244-0988-8
- DOI
- 10.1109/ACC.2007.4282583
- language
- English
- LU publication?
- yes
- id
- bc6b9943-2fc6-4ac6-832a-6cacb0907926 (old id 1407732)
- date added to LUP
- 2016-04-01 17:14:12
- date last changed
- 2022-03-23 00:16:46
@inproceedings{bc6b9943-2fc6-4ac6-832a-6cacb0907926,
abstract = {{The control of synthetic genetic regulatory networks is an emerging engineering challenge. In this study, we propose a new synthetic genetic network that behaves as a digital clock, producing square waveform oscillations. We analyze two models of the network: a deterministic model based on Michaelis-Menten kinetics, as well as a stochastic model based on the Gillespie algorithm. Both models predict regions of oscillatory behavior; the deterministic model provides insight into the conditions required to produce the oscillating clock-like behavior, while the stochastic model is truer to natural dynamics. Intracellular stochasticity is seen to contribute phase noise to the oscillator, and we propose improvements for the network and discuss the conceptual foundations of these improvements.}},
author = {{Ugander, Johan and Dunlop, Mary J. and Murray, Richard M.}},
booktitle = {{American Control Conference, 2007, vols 1-13}},
isbn = {{1-4244-0988-8}},
issn = {{0743-1619}},
language = {{eng}},
pages = {{2678--2682}},
publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
title = {{Analysis of a digital clock for molecular computing}},
url = {{http://dx.doi.org/10.1109/ACC.2007.4282583}},
doi = {{10.1109/ACC.2007.4282583}},
year = {{2007}},
}