Advanced

Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

Bergholdt, Regine; Storling, Zenia M.; Lage, Kasper; Karlberg, E. Olof; Olason, Pall I.; Aalund, Mogens; Nerup, Jörn LU ; Brunak, Soren; Workman, Christopher T. and Pociot, Flemming LU (2007) In Genome Biology 8(11).
Abstract
We have developed an integrative analysis method combining genetic interactions, identified using type l diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/ proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genome Biology
volume
8
issue
11
publisher
BioMed Central
external identifiers
  • wos:000252101100027
  • scopus:46349086693
ISSN
1474-7596
DOI
10.1186/gb-2007-8-11-r253
language
English
LU publication?
yes
id
c766794c-8589-4172-b2d6-58ce2cdc97af (old id 1408313)
date added to LUP
2009-05-29 12:42:23
date last changed
2017-01-01 04:47:13
@article{c766794c-8589-4172-b2d6-58ce2cdc97af,
  abstract     = {We have developed an integrative analysis method combining genetic interactions, identified using type l diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/ proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.},
  author       = {Bergholdt, Regine and Storling, Zenia M. and Lage, Kasper and Karlberg, E. Olof and Olason, Pall I. and Aalund, Mogens and Nerup, Jörn and Brunak, Soren and Workman, Christopher T. and Pociot, Flemming},
  issn         = {1474-7596},
  language     = {eng},
  number       = {11},
  publisher    = {BioMed Central},
  series       = {Genome Biology},
  title        = {Integrative analysis for finding genes and networks involved in diabetes and other complex diseases},
  url          = {http://dx.doi.org/10.1186/gb-2007-8-11-r253},
  volume       = {8},
  year         = {2007},
}