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Biological and genetic evolution of HIV type 1 in two siblings with different patterns of disease progression

Ripamonti, Chiara; Leitner, Thomas; Laurén, Anna LU ; Karlsson, Ingrid LU ; Pastore, Angela; Cavarelli, Mariangela; Antonsson, Liselotte LU ; Plebani, Anna; Fenyö, Eva Maria LU and Scarlatti, Gabriella (2007) In AIDS Research and Human Retroviruses 23(12). p.1531-1540
Abstract
To investigate the immunological and virological factors that may lead to different patterns of disease progression characteristic of HIV-1-infected children, two HIV-1-infected siblings, a slow and a fast progressor, were followed prospectively before the onset of highly active antiretroviral therapy. Viral coreceptor usage, including the use of CCR5/CXCR4 chimeric receptors, macrophage tropism, and sensitivity to the CC-chemokine RANTES, has been studied. An autologous and heterologous neutralizing antibody response has been documented using peripheral blood mononuclear cells- and GHOST(3) cell line-based assays. Viral evolution was investigated by env C2-V3 region sequence analysis. Although both siblings were infected with HIV-1 of the... (More)
To investigate the immunological and virological factors that may lead to different patterns of disease progression characteristic of HIV-1-infected children, two HIV-1-infected siblings, a slow and a fast progressor, were followed prospectively before the onset of highly active antiretroviral therapy. Viral coreceptor usage, including the use of CCR5/CXCR4 chimeric receptors, macrophage tropism, and sensitivity to the CC-chemokine RANTES, has been studied. An autologous and heterologous neutralizing antibody response has been documented using peripheral blood mononuclear cells- and GHOST(3) cell line-based assays. Viral evolution was investigated by env C2-V3 region sequence analysis. Although both siblings were infected with HIV-1 of the R5 phenotype, their viruses showed important biological differences. In the fast progressor there was a higher RANTES sensitivity of the early virus, an increased trend to change the mode of CCR5 receptor use, and a larger genetic evolution. Both children developed an autologous neutralizing antibody response starting from the second year with evidence of the continuous emergence of resistant variants. A marked viral genetic and phenotypic evolution was documented in the fast progressor sibling, which is accompanied by a high viral RANTES sensitivity and persistent neutralizing antibodies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
AIDS Research and Human Retroviruses
volume
23
issue
12
pages
1531 - 1540
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000252019200011
  • scopus:37549005204
ISSN
1931-8405
DOI
10.1089/aid.2006.0215
language
English
LU publication?
yes
id
9948c5c0-1295-49b2-9e7f-a06f792cd5ba (old id 1408442)
date added to LUP
2009-06-01 17:39:43
date last changed
2017-01-01 05:05:13
@article{9948c5c0-1295-49b2-9e7f-a06f792cd5ba,
  abstract     = {To investigate the immunological and virological factors that may lead to different patterns of disease progression characteristic of HIV-1-infected children, two HIV-1-infected siblings, a slow and a fast progressor, were followed prospectively before the onset of highly active antiretroviral therapy. Viral coreceptor usage, including the use of CCR5/CXCR4 chimeric receptors, macrophage tropism, and sensitivity to the CC-chemokine RANTES, has been studied. An autologous and heterologous neutralizing antibody response has been documented using peripheral blood mononuclear cells- and GHOST(3) cell line-based assays. Viral evolution was investigated by env C2-V3 region sequence analysis. Although both siblings were infected with HIV-1 of the R5 phenotype, their viruses showed important biological differences. In the fast progressor there was a higher RANTES sensitivity of the early virus, an increased trend to change the mode of CCR5 receptor use, and a larger genetic evolution. Both children developed an autologous neutralizing antibody response starting from the second year with evidence of the continuous emergence of resistant variants. A marked viral genetic and phenotypic evolution was documented in the fast progressor sibling, which is accompanied by a high viral RANTES sensitivity and persistent neutralizing antibodies.},
  author       = {Ripamonti, Chiara and Leitner, Thomas and Laurén, Anna and Karlsson, Ingrid and Pastore, Angela and Cavarelli, Mariangela and Antonsson, Liselotte and Plebani, Anna and Fenyö, Eva Maria and Scarlatti, Gabriella},
  issn         = {1931-8405},
  language     = {eng},
  number       = {12},
  pages        = {1531--1540},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {AIDS Research and Human Retroviruses},
  title        = {Biological and genetic evolution of HIV type 1 in two siblings with different patterns of disease progression},
  url          = {http://dx.doi.org/10.1089/aid.2006.0215},
  volume       = {23},
  year         = {2007},
}