Advanced

Hypothesis: social defeat is a risk factor for schizophrenia?

Selten, Jean-Paul and Cantor-Graae, Elizabeth LU (2007) In British Journal of Psychiatry 191. p.9-12
Abstract
The increased schizophrenia risks for residents of cities with high levels of competition and for members of disadvantaged groups (for example migrants from low- and middle-income countries, people with low IQ, hearing impairments or a history of abuse) suggest that social factors are important for aetiology, Dopaminergic dysfunctioning is a key mechanism in pathogenesis. This editorial is a selective literature review to delineate a mechanism whereby social factors can disturb dopamine function in the brain. Experiments with rodents have shown that social defeat leads to dopaminergic hyperactivity and to behavioural sensitisation, whereby the animal displays an enhanced behavioural and dopamine response to dopamine agonists. Neuroreceptor... (More)
The increased schizophrenia risks for residents of cities with high levels of competition and for members of disadvantaged groups (for example migrants from low- and middle-income countries, people with low IQ, hearing impairments or a history of abuse) suggest that social factors are important for aetiology, Dopaminergic dysfunctioning is a key mechanism in pathogenesis. This editorial is a selective literature review to delineate a mechanism whereby social factors can disturb dopamine function in the brain. Experiments with rodents have shown that social defeat leads to dopaminergic hyperactivity and to behavioural sensitisation, whereby the animal displays an enhanced behavioural and dopamine response to dopamine agonists. Neuroreceptor imaging studies have demonstrated the same phenomenain patients with schizophrenia who had never received antipsychotics, In humans, the chronic experience of social defeat may lead to sensitisation (and/or increased baseline activity) of the mesolimbic dopamine system and thereby increase the risk for schizophrenia. Declaration of interest None. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Psychiatry
volume
191
pages
9 - 12
publisher
Royal College of Psychiatrists
external identifiers
  • wos:000251939300002
  • scopus:37249038472
ISSN
0007-1250
DOI
10.1192/bjp.191.51.s9
language
English
LU publication?
yes
id
45f6f7ab-abc9-43c7-8a96-87f9a0ded9d8 (old id 1409110)
date added to LUP
2009-06-01 16:06:47
date last changed
2017-11-12 03:26:02
@misc{45f6f7ab-abc9-43c7-8a96-87f9a0ded9d8,
  abstract     = {The increased schizophrenia risks for residents of cities with high levels of competition and for members of disadvantaged groups (for example migrants from low- and middle-income countries, people with low IQ, hearing impairments or a history of abuse) suggest that social factors are important for aetiology, Dopaminergic dysfunctioning is a key mechanism in pathogenesis. This editorial is a selective literature review to delineate a mechanism whereby social factors can disturb dopamine function in the brain. Experiments with rodents have shown that social defeat leads to dopaminergic hyperactivity and to behavioural sensitisation, whereby the animal displays an enhanced behavioural and dopamine response to dopamine agonists. Neuroreceptor imaging studies have demonstrated the same phenomenain patients with schizophrenia who had never received antipsychotics, In humans, the chronic experience of social defeat may lead to sensitisation (and/or increased baseline activity) of the mesolimbic dopamine system and thereby increase the risk for schizophrenia. Declaration of interest None.},
  author       = {Selten, Jean-Paul and Cantor-Graae, Elizabeth},
  issn         = {0007-1250},
  language     = {eng},
  pages        = {9--12},
  publisher    = {Royal College of Psychiatrists},
  series       = {British Journal of Psychiatry},
  title        = {Hypothesis: social defeat is a risk factor for schizophrenia?},
  url          = {http://dx.doi.org/10.1192/bjp.191.51.s9},
  volume       = {191},
  year         = {2007},
}