Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung's disease
(2003) In Pediatric Surgery International 19(9-10). p.662-668- Abstract
- Surgery for Hirschsprung's disease is often complicated by post-operative bowel motility disorders. The impact of intestinal neural histology on the surgical outcome has been previously studied, but no information is available concerning the influence of the distribution of interstitial cells of Cajal (ICC) on these complications. These cells are considered to be pacemakers in the gastrointestinal tract. The aim of this study was to assess the distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease and confront these results with the clinical outcome. Using immunohistochemistry for light microscopy, we compared the pattern of distribution of ICC in the proximal segment of resected bowel in Hirschsprung's... (More)
- Surgery for Hirschsprung's disease is often complicated by post-operative bowel motility disorders. The impact of intestinal neural histology on the surgical outcome has been previously studied, but no information is available concerning the influence of the distribution of interstitial cells of Cajal (ICC) on these complications. These cells are considered to be pacemakers in the gastrointestinal tract. The aim of this study was to assess the distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease and confront these results with the clinical outcome. Using immunohistochemistry for light microscopy, we compared the pattern of distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease with that in normal colon. We correlated these results with the corresponding neural intestinal histology determined by CD56 and the protein gene product 9.5 immunohistochemistry. The distribution of ICC in the proximal segment of resected bowel is identical to that of normal colon, regardless of normal or abnormal colon innervation. ICC distribution does not seem to contribute to post-operative bowel motility disorders in patients operated for Hirschsprung's disease (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1128188
- author
- Newman, C J ; Laurini, Ricardo LU ; Lesbros, Y ; Reinberg, O and Meyrat, B J
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Surgery International
- volume
- 19
- issue
- 9-10
- pages
- 662 - 668
- publisher
- Springer
- external identifiers
-
- pmid:14566416
- scopus:0345863392
- pmid:14566416
- ISSN
- 1437-9813
- DOI
- 10.1007/s00383-003-1026-1
- language
- English
- LU publication?
- yes
- id
- 140b520b-f725-4267-a3e3-d2ab20da7839 (old id 1128188)
- date added to LUP
- 2016-04-01 17:05:53
- date last changed
- 2022-01-29 00:17:40
@article{140b520b-f725-4267-a3e3-d2ab20da7839,
abstract = {{Surgery for Hirschsprung's disease is often complicated by post-operative bowel motility disorders. The impact of intestinal neural histology on the surgical outcome has been previously studied, but no information is available concerning the influence of the distribution of interstitial cells of Cajal (ICC) on these complications. These cells are considered to be pacemakers in the gastrointestinal tract. The aim of this study was to assess the distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease and confront these results with the clinical outcome. Using immunohistochemistry for light microscopy, we compared the pattern of distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease with that in normal colon. We correlated these results with the corresponding neural intestinal histology determined by CD56 and the protein gene product 9.5 immunohistochemistry. The distribution of ICC in the proximal segment of resected bowel is identical to that of normal colon, regardless of normal or abnormal colon innervation. ICC distribution does not seem to contribute to post-operative bowel motility disorders in patients operated for Hirschsprung's disease}},
author = {{Newman, C J and Laurini, Ricardo and Lesbros, Y and Reinberg, O and Meyrat, B J}},
issn = {{1437-9813}},
language = {{eng}},
number = {{9-10}},
pages = {{662--668}},
publisher = {{Springer}},
series = {{Pediatric Surgery International}},
title = {{Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung's disease}},
url = {{http://dx.doi.org/10.1007/s00383-003-1026-1}},
doi = {{10.1007/s00383-003-1026-1}},
volume = {{19}},
year = {{2003}},
}