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Molecularly imprinted polymers as antibody and receptor mimics for assays, sensors and drug discovery

Ye, Lei LU and Haupt, Karsten Olaf LU (2004) In Analytical and Bioanalytical Chemistry 378(8). p.1887-1897
Abstract
Biological receptors play an important role in affinity-based drug assays, biosensors, and at different stages during the modern drug discovery process. The molecular imprinting technology that has recently emerged has shown great potential for producing biomimetic receptors that challenge their natural counterparts. In this paper, we will overview recent progress in the use of molecularly imprinted polymers for drug assays, assembly of biomimetic sensors, and screening of combinatorial libraries. In addition, examples of using artificially-created binding sites to control synthetic reactions will be discussed. The "screening-of-building blocks" approach is expected to accelerate generation of valuable lead compounds, without the costly... (More)
Biological receptors play an important role in affinity-based drug assays, biosensors, and at different stages during the modern drug discovery process. The molecular imprinting technology that has recently emerged has shown great potential for producing biomimetic receptors that challenge their natural counterparts. In this paper, we will overview recent progress in the use of molecularly imprinted polymers for drug assays, assembly of biomimetic sensors, and screening of combinatorial libraries. In addition, examples of using artificially-created binding sites to control synthetic reactions will be discussed. The "screening-of-building blocks" approach is expected to accelerate generation of valuable lead compounds, without the costly synthesis of large chemical libraries. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical and Bioanalytical Chemistry
volume
378
issue
8
pages
1887 - 1897
publisher
Springer
external identifiers
  • pmid:15064898
  • wos:000220678000003
  • scopus:2442421099
ISSN
1618-2642
DOI
10.1007/s00216-003-2450-8
language
English
LU publication?
yes
id
407455c3-3866-4513-a6aa-c6cd65955927 (old id 141047)
date added to LUP
2007-07-17 08:23:05
date last changed
2017-11-19 03:29:38
@article{407455c3-3866-4513-a6aa-c6cd65955927,
  abstract     = {Biological receptors play an important role in affinity-based drug assays, biosensors, and at different stages during the modern drug discovery process. The molecular imprinting technology that has recently emerged has shown great potential for producing biomimetic receptors that challenge their natural counterparts. In this paper, we will overview recent progress in the use of molecularly imprinted polymers for drug assays, assembly of biomimetic sensors, and screening of combinatorial libraries. In addition, examples of using artificially-created binding sites to control synthetic reactions will be discussed. The "screening-of-building blocks" approach is expected to accelerate generation of valuable lead compounds, without the costly synthesis of large chemical libraries.},
  author       = {Ye, Lei and Haupt, Karsten Olaf},
  issn         = {1618-2642},
  language     = {eng},
  number       = {8},
  pages        = {1887--1897},
  publisher    = {Springer},
  series       = {Analytical and Bioanalytical Chemistry},
  title        = {Molecularly imprinted polymers as antibody and receptor mimics for assays, sensors and drug discovery},
  url          = {http://dx.doi.org/10.1007/s00216-003-2450-8},
  volume       = {378},
  year         = {2004},
}