Molecularly imprinted polymers as antibody and receptor mimics for assays, sensors and drug discovery
Ye, Lei LU
and Haupt, Karsten Olaf
LU
(2004)
In Analytical and Bioanalytical Chemistry
378(8).
p.1887-1897
- Abstract
- Biological receptors play an important role in affinity-based drug assays, biosensors, and at different stages during the modern drug discovery process. The molecular imprinting technology that has recently emerged has shown great potential for producing biomimetic receptors that challenge their natural counterparts. In this paper, we will overview recent progress in the use of molecularly imprinted polymers for drug assays, assembly of biomimetic sensors, and screening of combinatorial libraries. In addition, examples of using artificially-created binding sites to control synthetic reactions will be discussed. The "screening-of-building blocks" approach is expected to accelerate generation of valuable lead compounds, without the costly... (More)
- Biological receptors play an important role in affinity-based drug assays, biosensors, and at different stages during the modern drug discovery process. The molecular imprinting technology that has recently emerged has shown great potential for producing biomimetic receptors that challenge their natural counterparts. In this paper, we will overview recent progress in the use of molecularly imprinted polymers for drug assays, assembly of biomimetic sensors, and screening of combinatorial libraries. In addition, examples of using artificially-created binding sites to control synthetic reactions will be discussed. The "screening-of-building blocks" approach is expected to accelerate generation of valuable lead compounds, without the costly synthesis of large chemical libraries. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/141047
- author
- Ye, Lei
LU
and Haupt, Karsten Olaf
LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Analytical and Bioanalytical Chemistry
- volume
- 378
- issue
- 8
- pages
- 1887 - 1897
- publisher
- Springer
- external identifiers
-
- pmid:15064898
- wos:000220678000003
- scopus:2442421099
- ISSN
- 1618-2642
- DOI
- 10.1007/s00216-003-2450-8
- language
- English
- LU publication?
- yes
- id
- 407455c3-3866-4513-a6aa-c6cd65955927 (old id 141047)
- date added to LUP
- 2016-04-01 11:53:01
- date last changed
- 2022-04-20 23:09:00
@article{407455c3-3866-4513-a6aa-c6cd65955927,
abstract = {{Biological receptors play an important role in affinity-based drug assays, biosensors, and at different stages during the modern drug discovery process. The molecular imprinting technology that has recently emerged has shown great potential for producing biomimetic receptors that challenge their natural counterparts. In this paper, we will overview recent progress in the use of molecularly imprinted polymers for drug assays, assembly of biomimetic sensors, and screening of combinatorial libraries. In addition, examples of using artificially-created binding sites to control synthetic reactions will be discussed. The "screening-of-building blocks" approach is expected to accelerate generation of valuable lead compounds, without the costly synthesis of large chemical libraries.}},
author = {{Ye, Lei and Haupt, Karsten Olaf}},
issn = {{1618-2642}},
language = {{eng}},
number = {{8}},
pages = {{1887--1897}},
publisher = {{Springer}},
series = {{Analytical and Bioanalytical Chemistry}},
title = {{Molecularly imprinted polymers as antibody and receptor mimics for assays, sensors and drug discovery}},
url = {{http://dx.doi.org/10.1007/s00216-003-2450-8}},
doi = {{10.1007/s00216-003-2450-8}},
volume = {{378}},
year = {{2004}},
}