Advanced

Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant Erythrina crista-galli

Weber, D; Sterner, Olov LU ; Anke, T; Gorzalczancy, S; Martino, V and Acevedo, C (2004) In Journal of Antibiotics 57(9). p.559-563
Abstract
Phomol (1), a novel antibiotic, was isolated from fermentations of a Phomopsis species in the course of a screening of endophytic fungi from the medicinal plant Erythrina crista-galli. For this Argentinean leguminosa anti inflammatory and neuroleptic activities have been described. The compound exhibits antifungal, antibacterial and weak cytotoxic acticity. The anti inflammatory activity was tested in different reporter gene assays (TNF-alpha, STAT1/STAT2 and NF-kappaB) and in an ear edema model in mice. In the reporter gene assays I exhibited no activity, whereas I showed interesting antiinflammatory activity in the mouse ear assay. The compound is a polyketide lactone and its structure was elucidated by spectroscopic methods.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Antibiotics
volume
57
issue
9
pages
559 - 563
publisher
Japan Antibiotics Research Association
external identifiers
  • pmid:15580955
  • wos:000224135900001
  • scopus:5044233773
ISSN
0021-8820
language
English
LU publication?
yes
id
e6f3984d-d4b7-414a-b859-b3c5eed5a286 (old id 141160)
alternative location
http://www.antibiotics.or.jp/journal/contents/vol-57/full_text/57-9/ja57_0559.pdf
date added to LUP
2007-07-10 15:45:46
date last changed
2017-12-10 04:35:10
@article{e6f3984d-d4b7-414a-b859-b3c5eed5a286,
  abstract     = {Phomol (1), a novel antibiotic, was isolated from fermentations of a Phomopsis species in the course of a screening of endophytic fungi from the medicinal plant Erythrina crista-galli. For this Argentinean leguminosa anti inflammatory and neuroleptic activities have been described. The compound exhibits antifungal, antibacterial and weak cytotoxic acticity. The anti inflammatory activity was tested in different reporter gene assays (TNF-alpha, STAT1/STAT2 and NF-kappaB) and in an ear edema model in mice. In the reporter gene assays I exhibited no activity, whereas I showed interesting antiinflammatory activity in the mouse ear assay. The compound is a polyketide lactone and its structure was elucidated by spectroscopic methods.},
  author       = {Weber, D and Sterner, Olov and Anke, T and Gorzalczancy, S and Martino, V and Acevedo, C},
  issn         = {0021-8820},
  language     = {eng},
  number       = {9},
  pages        = {559--563},
  publisher    = {Japan Antibiotics Research Association},
  series       = {Journal of Antibiotics},
  title        = {Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant Erythrina crista-galli},
  volume       = {57},
  year         = {2004},
}