Predictors of psychosis: a 50-year follow-up of the Lundby population.
(2010) In European Archives of Psychiatry and Clinical Neuroscience 260(2). p.113-125- Abstract
- Behavioural and neuropsychological vulnerability have been associated with an increased risk of psychosis. We investigated whether certain clusters of premorbid behavioural and personality-related signs and symptoms were predictors of nonaffective and/or affective psychosis and schizophrenia, respectively, in a 50-year follow-up of an unselected general community population. Total population cohorts from the same catchment area in 1947 (n = 2,503) and 1957 (n = 3,215) that had been rated for behavioural items and enduring symptoms were followed up to 1997 regarding first-incidence of DSM-IV nonaffective and/or affective psychosis. Attrition was 1-6%. The influence of the background factors, aggregated in dichotomous variables (predictors),... (More)
- Behavioural and neuropsychological vulnerability have been associated with an increased risk of psychosis. We investigated whether certain clusters of premorbid behavioural and personality-related signs and symptoms were predictors of nonaffective and/or affective psychosis and schizophrenia, respectively, in a 50-year follow-up of an unselected general community population. Total population cohorts from the same catchment area in 1947 (n = 2,503) and 1957 (n = 3,215) that had been rated for behavioural items and enduring symptoms were followed up to 1997 regarding first-incidence of DSM-IV nonaffective and/or affective psychosis. Attrition was 1-6%. The influence of the background factors, aggregated in dichotomous variables (predictors), on time to occurrence of nonaffective and/or affective psychosis was assessed by means of Cox regression models. In multivariate models the predictors nervous-tense, blunt-deteriorated, paranoid-schizotypal and tired-distracted were significantly associated with subsequent nonaffective and/or affective psychosis. In simple models, down-semidepressed, sensitive-frail and easily hurt were significantly associated with development of psychosis. When schizophrenia was analysed separately nervous-tense remained significant in the multivariate model, although blunt-deteriorated, paranoid-schizotypal and tired-distracted did not; and abnormal-antisocial reached significance. To conclude, we found some evidence for anxiety-proneness, affective/cognitive blunting, poor concentration, personality cluster-A like traits and interpersonal sensitivity to be associated with general psychosis vulnerability. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1411877
- author
- Bogren, Mats LU ; Mattisson, Cecilia LU ; Tambs, Kristian ; Horstmann, Vibeke LU ; Munk-Jørgensen, Povl and Nettelbladt, Per LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Archives of Psychiatry and Clinical Neuroscience
- volume
- 260
- issue
- 2
- pages
- 113 - 125
- publisher
- Springer
- external identifiers
-
- wos:000275085300004
- pmid:19479298
- scopus:77950857995
- ISSN
- 1433-8491
- DOI
- 10.1007/s00406-009-0022-4
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Psychiatry (Lund) (013303000), Division of Occupational Therapy (Closed 2012) (013025000)
- id
- 72fa2168-2ddf-45cd-99c7-e741c2b0a5ef (old id 1411877)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19479298?dopt=Abstract
- date added to LUP
- 2016-04-04 09:03:31
- date last changed
- 2022-01-29 08:01:17
@article{72fa2168-2ddf-45cd-99c7-e741c2b0a5ef,
abstract = {{Behavioural and neuropsychological vulnerability have been associated with an increased risk of psychosis. We investigated whether certain clusters of premorbid behavioural and personality-related signs and symptoms were predictors of nonaffective and/or affective psychosis and schizophrenia, respectively, in a 50-year follow-up of an unselected general community population. Total population cohorts from the same catchment area in 1947 (n = 2,503) and 1957 (n = 3,215) that had been rated for behavioural items and enduring symptoms were followed up to 1997 regarding first-incidence of DSM-IV nonaffective and/or affective psychosis. Attrition was 1-6%. The influence of the background factors, aggregated in dichotomous variables (predictors), on time to occurrence of nonaffective and/or affective psychosis was assessed by means of Cox regression models. In multivariate models the predictors nervous-tense, blunt-deteriorated, paranoid-schizotypal and tired-distracted were significantly associated with subsequent nonaffective and/or affective psychosis. In simple models, down-semidepressed, sensitive-frail and easily hurt were significantly associated with development of psychosis. When schizophrenia was analysed separately nervous-tense remained significant in the multivariate model, although blunt-deteriorated, paranoid-schizotypal and tired-distracted did not; and abnormal-antisocial reached significance. To conclude, we found some evidence for anxiety-proneness, affective/cognitive blunting, poor concentration, personality cluster-A like traits and interpersonal sensitivity to be associated with general psychosis vulnerability.}},
author = {{Bogren, Mats and Mattisson, Cecilia and Tambs, Kristian and Horstmann, Vibeke and Munk-Jørgensen, Povl and Nettelbladt, Per}},
issn = {{1433-8491}},
language = {{eng}},
number = {{2}},
pages = {{113--125}},
publisher = {{Springer}},
series = {{European Archives of Psychiatry and Clinical Neuroscience}},
title = {{Predictors of psychosis: a 50-year follow-up of the Lundby population.}},
url = {{http://dx.doi.org/10.1007/s00406-009-0022-4}},
doi = {{10.1007/s00406-009-0022-4}},
volume = {{260}},
year = {{2010}},
}