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Scaling up effects in the organic laboratory

Persson, Anna and Lindström, Ulf LU (2004) In Journal of Chemical Education 81(9). p.1353-1354
Abstract
A simple, yet safe and effective set of experiments to expose chemistry students to some of the effects that may be encountered when scaling up an organic reaction is described. The exothermic Diels–Alder reaction between maleic anhydride and cyclopentadiene was found to be ideal for our purposes and was performed in small, medium, and large scale for comparison. The observed differences of heat evolution between the three scales were significant. Also, to demonstrate how excess heat evolution can be controlled by simple means, two additional experiments in which the reaction was run either with small glass helices or water present were performed. The experiments were combined with some simple calculations that provided graphic... (More)
A simple, yet safe and effective set of experiments to expose chemistry students to some of the effects that may be encountered when scaling up an organic reaction is described. The exothermic Diels–Alder reaction between maleic anhydride and cyclopentadiene was found to be ideal for our purposes and was performed in small, medium, and large scale for comparison. The observed differences of heat evolution between the three scales were significant. Also, to demonstrate how excess heat evolution can be controlled by simple means, two additional experiments in which the reaction was run either with small glass helices or water present were performed. The experiments were combined with some simple calculations that provided graphic illustrations of the observed differences, which aided the students in their understanding of the topic. This assignment can easily be adapted to work with both small and large groups of students. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Chemical Education
volume
81
issue
9
pages
1353 - 1354
publisher
The American Chemical Society
external identifiers
  • wos:000223203100030
  • scopus:4344632009
ISSN
0021-9584
language
English
LU publication?
yes
id
0a17182e-987f-4d10-8504-8cfb8d7c28a7 (old id 141209)
alternative location
http://jchemed.chem.wisc.edu/Journal/Issues/2004/Sep/abs1353.html
date added to LUP
2007-07-10 13:32:04
date last changed
2017-01-01 07:16:45
@article{0a17182e-987f-4d10-8504-8cfb8d7c28a7,
  abstract     = {A simple, yet safe and effective set of experiments to expose chemistry students to some of the effects that may be encountered when scaling up an organic reaction is described. The exothermic Diels–Alder reaction between maleic anhydride and cyclopentadiene was found to be ideal for our purposes and was performed in small, medium, and large scale for comparison. The observed differences of heat evolution between the three scales were significant. Also, to demonstrate how excess heat evolution can be controlled by simple means, two additional experiments in which the reaction was run either with small glass helices or water present were performed. The experiments were combined with some simple calculations that provided graphic illustrations of the observed differences, which aided the students in their understanding of the topic. This assignment can easily be adapted to work with both small and large groups of students.},
  author       = {Persson, Anna and Lindström, Ulf},
  issn         = {0021-9584},
  language     = {eng},
  number       = {9},
  pages        = {1353--1354},
  publisher    = {The American Chemical Society},
  series       = {Journal of Chemical Education},
  title        = {Scaling up effects in the organic laboratory},
  volume       = {81},
  year         = {2004},
}