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Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes.

Nordin Fredrikson, Gunilla LU ; Anand, D; Hopkins, D; Corder, R; Alm, Ragnar LU ; Bengtsson, Eva LU ; Shah, P; Lahiri, A and Nilsson, Jan LU (2009) In Diabetologia 52. p.1426-1433
Abstract
AIMS/HYPOTHESIS: Oxidation of LDL in the arterial extracellular matrix is a key event in the development of atherosclerosis and autoantibodies against oxidised LDL antigens reflect disease severity and the risk of developing acute cardiovascular events. Since type 2 diabetes is associated with increased oxidative stress, we tested the hypothesis that autoantibodies against oxidised LDL antigens are biomarkers for vascular complications in diabetes. METHODS: We studied 497 patients with type 2 diabetes without clinical signs of coronary heart disease. Oxidised LDL autoantibodies were determined by ELISA detecting IgG and IgM specific for native and malondialdehyde (MDA)-modified apolipoprotein B-100 peptides p45 and p210. The severity of... (More)
AIMS/HYPOTHESIS: Oxidation of LDL in the arterial extracellular matrix is a key event in the development of atherosclerosis and autoantibodies against oxidised LDL antigens reflect disease severity and the risk of developing acute cardiovascular events. Since type 2 diabetes is associated with increased oxidative stress, we tested the hypothesis that autoantibodies against oxidised LDL antigens are biomarkers for vascular complications in diabetes. METHODS: We studied 497 patients with type 2 diabetes without clinical signs of coronary heart disease. Oxidised LDL autoantibodies were determined by ELISA detecting IgG and IgM specific for native and malondialdehyde (MDA)-modified apolipoprotein B-100 peptides p45 and p210. The severity of coronary disease was assessed as the coronary artery calcium score. RESULTS: Patients affected by retinopathy had significantly higher levels of IgG against MDA-p45 and MDA-p210. In contrast, high levels of autoantibodies against the corresponding native peptides were associated with less coronary calcification and a lower risk of progression of coronary disease. CONCLUSIONS/INTERPRETATION: Our observations suggest that LDL oxidation is involved in the pathogenesis of diabetic retinopathy and that autoantibodies against apolipoprotein B peptides may act as biomarkers for both micro- and macrovascular complications in diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetologia
volume
52
pages
1426 - 1433
publisher
Springer Verlag
external identifiers
  • wos:000266496000027
  • pmid:19448981
  • scopus:67349151367
ISSN
1432-0428
DOI
10.1007/s00125-009-1377-9
language
English
LU publication?
yes
id
31056c7a-4cbc-4876-b8a0-908cea6d772c (old id 1412193)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19448981?dopt=Abstract
date added to LUP
2009-06-03 17:00:04
date last changed
2017-01-22 03:31:38
@article{31056c7a-4cbc-4876-b8a0-908cea6d772c,
  abstract     = {AIMS/HYPOTHESIS: Oxidation of LDL in the arterial extracellular matrix is a key event in the development of atherosclerosis and autoantibodies against oxidised LDL antigens reflect disease severity and the risk of developing acute cardiovascular events. Since type 2 diabetes is associated with increased oxidative stress, we tested the hypothesis that autoantibodies against oxidised LDL antigens are biomarkers for vascular complications in diabetes. METHODS: We studied 497 patients with type 2 diabetes without clinical signs of coronary heart disease. Oxidised LDL autoantibodies were determined by ELISA detecting IgG and IgM specific for native and malondialdehyde (MDA)-modified apolipoprotein B-100 peptides p45 and p210. The severity of coronary disease was assessed as the coronary artery calcium score. RESULTS: Patients affected by retinopathy had significantly higher levels of IgG against MDA-p45 and MDA-p210. In contrast, high levels of autoantibodies against the corresponding native peptides were associated with less coronary calcification and a lower risk of progression of coronary disease. CONCLUSIONS/INTERPRETATION: Our observations suggest that LDL oxidation is involved in the pathogenesis of diabetic retinopathy and that autoantibodies against apolipoprotein B peptides may act as biomarkers for both micro- and macrovascular complications in diabetes.},
  author       = {Nordin Fredrikson, Gunilla and Anand, D and Hopkins, D and Corder, R and Alm, Ragnar and Bengtsson, Eva and Shah, P and Lahiri, A and Nilsson, Jan},
  issn         = {1432-0428},
  language     = {eng},
  pages        = {1426--1433},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes.},
  url          = {http://dx.doi.org/10.1007/s00125-009-1377-9},
  volume       = {52},
  year         = {2009},
}