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Outcome in a Prospective Phase II Trial of Medically Inoperable Stage I Non-Small-Cell Lung Cancer Patients Treated With Stereotactic Body Radiotherapy.

Baumann, Pia; Nyman, Jan; Hoyer, Morten; Wennberg, Berit; Gagliardi, Giovanna; Lax, Ingmar; Drugge, Ninni; Ekberg, Lars; Friesland, Signe and Johansson, Karl-Axel, et al. (2009) In Journal of Clinical Oncology 27. p.3290-3296
Abstract
PURPOSE: The impact of stereotactic body radiotherapy (SBRT) on 3-year progression-free survival of medically inoperable patients with stage I non-small-cell lung cancer (NSCLC) was analyzed in a prospective phase II study. PATIENTS AND METHODS: Fifty seven patients with T1NOMO (70%) and T2N0M0 (30%) were included between August 2003 and September 2005 at seven different centers in Sweden, Norway, and Denmark and observed up to 36 months. SBRT was delivered with 15 Gy times three at the 67% isodose of the planning target volume. RESULTS: Progression-free survival at 3 years was 52%. Overall- and cancer-specific survival at 1, 2, and 3 years was 86%, 65%, 60%, and 93%, 88%, 88%, respectively. There was no statistically significant... (More)
PURPOSE: The impact of stereotactic body radiotherapy (SBRT) on 3-year progression-free survival of medically inoperable patients with stage I non-small-cell lung cancer (NSCLC) was analyzed in a prospective phase II study. PATIENTS AND METHODS: Fifty seven patients with T1NOMO (70%) and T2N0M0 (30%) were included between August 2003 and September 2005 at seven different centers in Sweden, Norway, and Denmark and observed up to 36 months. SBRT was delivered with 15 Gy times three at the 67% isodose of the planning target volume. RESULTS: Progression-free survival at 3 years was 52%. Overall- and cancer-specific survival at 1, 2, and 3 years was 86%, 65%, 60%, and 93%, 88%, 88%, respectively. There was no statistically significant difference in survival between patients with T1 or T2 tumors. At a median follow-up of 35 months (range, 4 to 47 months), 27 patients (47%) were deceased, seven as a result of lung cancer and 20 as a result of concurrent disease. Kaplan-Meier estimated local control at 3 years was 92%. Local relapse was observed in four patients (7%). Regional relapse was observed in three patients (5%). Nine patients (16%) developed distant metastases. The estimated risk of all failure (local, regional, or distant metastases) was increased in patients with T2 (41%) compared with those with T1 (18%) tumors (P = .027). CONCLUSION: With a 3-year local tumor control rate higher than 90% with limited toxicity, SBRT emerges as state-of-the-art treatment for medically inoperable stage I NSCLC and may even challenge surgery in operable instances. (Less)
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Contribution to journal
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published
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Journal of Clinical Oncology
volume
27
pages
3290 - 3296
publisher
American Society of Clinical Oncology
external identifiers
  • wos:000267821400007
  • pmid:19414667
  • scopus:70249108166
ISSN
1527-7755
DOI
10.1200/JCO.2008.21.5681
language
English
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yes
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c8827f47-7e02-4715-9cea-78859ae42e38 (old id 1412692)
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http://www.ncbi.nlm.nih.gov/pubmed/19414667?dopt=Abstract
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2009-06-01 09:26:36
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2017-12-10 04:41:45
@article{c8827f47-7e02-4715-9cea-78859ae42e38,
  abstract     = {PURPOSE: The impact of stereotactic body radiotherapy (SBRT) on 3-year progression-free survival of medically inoperable patients with stage I non-small-cell lung cancer (NSCLC) was analyzed in a prospective phase II study. PATIENTS AND METHODS: Fifty seven patients with T1NOMO (70%) and T2N0M0 (30%) were included between August 2003 and September 2005 at seven different centers in Sweden, Norway, and Denmark and observed up to 36 months. SBRT was delivered with 15 Gy times three at the 67% isodose of the planning target volume. RESULTS: Progression-free survival at 3 years was 52%. Overall- and cancer-specific survival at 1, 2, and 3 years was 86%, 65%, 60%, and 93%, 88%, 88%, respectively. There was no statistically significant difference in survival between patients with T1 or T2 tumors. At a median follow-up of 35 months (range, 4 to 47 months), 27 patients (47%) were deceased, seven as a result of lung cancer and 20 as a result of concurrent disease. Kaplan-Meier estimated local control at 3 years was 92%. Local relapse was observed in four patients (7%). Regional relapse was observed in three patients (5%). Nine patients (16%) developed distant metastases. The estimated risk of all failure (local, regional, or distant metastases) was increased in patients with T2 (41%) compared with those with T1 (18%) tumors (P = .027). CONCLUSION: With a 3-year local tumor control rate higher than 90% with limited toxicity, SBRT emerges as state-of-the-art treatment for medically inoperable stage I NSCLC and may even challenge surgery in operable instances.},
  author       = {Baumann, Pia and Nyman, Jan and Hoyer, Morten and Wennberg, Berit and Gagliardi, Giovanna and Lax, Ingmar and Drugge, Ninni and Ekberg, Lars and Friesland, Signe and Johansson, Karl-Axel and Lund, Jo-Åsmund and Morhed, Elisabeth and Nilsson, Kristina and Levin, Nina and Paludan, Merete and Sederholm, Christer and Traberg, Anders and Wittgren, Lena and Lewensohn, Rolf},
  issn         = {1527-7755},
  language     = {eng},
  pages        = {3290--3296},
  publisher    = {American Society of Clinical Oncology},
  series       = {Journal of Clinical Oncology},
  title        = {Outcome in a Prospective Phase II Trial of Medically Inoperable Stage I Non-Small-Cell Lung Cancer Patients Treated With Stereotactic Body Radiotherapy.},
  url          = {http://dx.doi.org/10.1200/JCO.2008.21.5681},
  volume       = {27},
  year         = {2009},
}