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A combination of micro-porous membrane liquid–gas extraction and solid-phase trapping for ultra trace determination of benzene in urine

Ljungkvist, Göran; Azimi, Arman and Mathiasson, Lennart LU (2004) In Journal of Environmental Monitoring 6(2). p.143-146
Abstract
A method was developed for the determination of benzene in urine. The sample was pumped through the donor channel of a membrane extraction unit with a micro-porous membrane, separating the donor channel from an identical acceptor channel purged with nitrogen. The analyte reached the acceptor channel by diffusion through the membrane and was then swept by the carrier to a solid sorbent tube, where it was trapped. The analyte was subsequently thermally desorbed and analyzed by gas chromatography (GC) with mass selective detection (MS). After optimization, the recovery was close to quantitative, or 95%. Purging the membrane unit with pure water inbetween the samples eliminated any memory effects. The linearity was good in the concentration... (More)
A method was developed for the determination of benzene in urine. The sample was pumped through the donor channel of a membrane extraction unit with a micro-porous membrane, separating the donor channel from an identical acceptor channel purged with nitrogen. The analyte reached the acceptor channel by diffusion through the membrane and was then swept by the carrier to a solid sorbent tube, where it was trapped. The analyte was subsequently thermally desorbed and analyzed by gas chromatography (GC) with mass selective detection (MS). After optimization, the recovery was close to quantitative, or 95%. Purging the membrane unit with pure water inbetween the samples eliminated any memory effects. The linearity was good in the concentration range examined (20–4000 ng l–1), with a correlation coefficient of 0.9996. The repeatability at 50 ng l–1 and 400 ng l–1 was 1.4% and 1.2%, respectively. The limit of detection was 12 ng l–1 and the limit of quantification 35 ng l–1. This enables assessment of benzene exposures of occupationally exposed subjects, of smokers and the majority of the general population. The developed method can be easily automated. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Environmental Monitoring
volume
6
issue
2
pages
143 - 146
publisher
Royal Society of Chemistry
external identifiers
  • wos:000220253400011
  • pmid:14760458
  • scopus:1542374621
ISSN
1464-0325
DOI
10.1039/b311201m
language
English
LU publication?
yes
id
3cb97d5b-131b-4375-850f-4081eb161ac5 (old id 141284)
date added to LUP
2007-06-27 10:37:29
date last changed
2017-01-01 04:23:45
@article{3cb97d5b-131b-4375-850f-4081eb161ac5,
  abstract     = {A method was developed for the determination of benzene in urine. The sample was pumped through the donor channel of a membrane extraction unit with a micro-porous membrane, separating the donor channel from an identical acceptor channel purged with nitrogen. The analyte reached the acceptor channel by diffusion through the membrane and was then swept by the carrier to a solid sorbent tube, where it was trapped. The analyte was subsequently thermally desorbed and analyzed by gas chromatography (GC) with mass selective detection (MS). After optimization, the recovery was close to quantitative, or 95%. Purging the membrane unit with pure water inbetween the samples eliminated any memory effects. The linearity was good in the concentration range examined (20–4000 ng l–1), with a correlation coefficient of 0.9996. The repeatability at 50 ng l–1 and 400 ng l–1 was 1.4% and 1.2%, respectively. The limit of detection was 12 ng l–1 and the limit of quantification 35 ng l–1. This enables assessment of benzene exposures of occupationally exposed subjects, of smokers and the majority of the general population. The developed method can be easily automated.},
  author       = {Ljungkvist, Göran and Azimi, Arman and Mathiasson, Lennart},
  issn         = {1464-0325},
  language     = {eng},
  number       = {2},
  pages        = {143--146},
  publisher    = {Royal Society of Chemistry},
  series       = {Journal of Environmental Monitoring},
  title        = {A combination of micro-porous membrane liquid–gas extraction and solid-phase trapping for ultra trace determination of benzene in urine},
  url          = {http://dx.doi.org/10.1039/b311201m},
  volume       = {6},
  year         = {2004},
}