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Airborne chemistry: acoustic levitation in chemical analysis

Santesson, Sabina LU and Nilsson, Staffan LU (2004) In Analytical and Bioanalytical Chemistry 378(7). p.1704-1709
Abstract
This review with 60 references describes a unique path to miniaturisation, that is, the use of acoustic levitation in analytical and bioanalytical chemistry applications. Levitation of small volumes of sample by means of a levitation technique can be used as a way to avoid solid walls around the sample, thus circumventing the main problem of miniaturisation, the unfavourable surface-to-volume ratio. Different techniques for sample levitation have been developed and improved. Of the levitation techniques described, acoustic or ultrasonic levitation fulfils all requirements for analytical chemistry applications. This technique has previously been used to study properties of molten materials and the equilibrium shape and stability of liquid... (More)
This review with 60 references describes a unique path to miniaturisation, that is, the use of acoustic levitation in analytical and bioanalytical chemistry applications. Levitation of small volumes of sample by means of a levitation technique can be used as a way to avoid solid walls around the sample, thus circumventing the main problem of miniaturisation, the unfavourable surface-to-volume ratio. Different techniques for sample levitation have been developed and improved. Of the levitation techniques described, acoustic or ultrasonic levitation fulfils all requirements for analytical chemistry applications. This technique has previously been used to study properties of molten materials and the equilibrium shape and stability of liquid drops. Temperature and mass transfer in levitated drops have also been described, as have crystallisation and microgravity applications.

The airborne analytical system described here is equipped with different and exchangeable remote detection systems. The levitated drops are normally in the 100 nL–2 mgrL volume range and additions to the levitated drop can be made in the pL-volume range.

The use of levitated drops in analytical and bioanalytical chemistry offers several benefits. Several remote detection systems are compatible with acoustic levitation, including fluorescence imaging detection, right angle light scattering, Raman spectroscopy, and X-ray diffraction. Applications include liquid/liquid extractions, solvent exchange, analyte enrichment, single-cell analysis, cell–cell communication studies, precipitation screening of proteins to establish nucleation conditions, and crystallisation of proteins and pharmaceuticals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical and Bioanalytical Chemistry
volume
378
issue
7
pages
1704 - 1709
publisher
Springer
external identifiers
  • wos:000220458400007
  • pmid:14762640
  • scopus:17644390506
ISSN
1618-2642
DOI
10.1007/s00216-003-2403-2
language
English
LU publication?
yes
id
519fd50f-0825-4cc4-8580-8cca352ce473 (old id 141347)
date added to LUP
2007-06-27 15:21:18
date last changed
2017-10-22 03:34:43
@article{519fd50f-0825-4cc4-8580-8cca352ce473,
  abstract     = {This review with 60 references describes a unique path to miniaturisation, that is, the use of acoustic levitation in analytical and bioanalytical chemistry applications. Levitation of small volumes of sample by means of a levitation technique can be used as a way to avoid solid walls around the sample, thus circumventing the main problem of miniaturisation, the unfavourable surface-to-volume ratio. Different techniques for sample levitation have been developed and improved. Of the levitation techniques described, acoustic or ultrasonic levitation fulfils all requirements for analytical chemistry applications. This technique has previously been used to study properties of molten materials and the equilibrium shape and stability of liquid drops. Temperature and mass transfer in levitated drops have also been described, as have crystallisation and microgravity applications.<br/><br>
The airborne analytical system described here is equipped with different and exchangeable remote detection systems. The levitated drops are normally in the 100 nL–2 mgrL volume range and additions to the levitated drop can be made in the pL-volume range.<br/><br>
The use of levitated drops in analytical and bioanalytical chemistry offers several benefits. Several remote detection systems are compatible with acoustic levitation, including fluorescence imaging detection, right angle light scattering, Raman spectroscopy, and X-ray diffraction. Applications include liquid/liquid extractions, solvent exchange, analyte enrichment, single-cell analysis, cell–cell communication studies, precipitation screening of proteins to establish nucleation conditions, and crystallisation of proteins and pharmaceuticals.},
  author       = {Santesson, Sabina and Nilsson, Staffan},
  issn         = {1618-2642},
  language     = {eng},
  number       = {7},
  pages        = {1704--1709},
  publisher    = {Springer},
  series       = {Analytical and Bioanalytical Chemistry},
  title        = {Airborne chemistry: acoustic levitation in chemical analysis},
  url          = {http://dx.doi.org/10.1007/s00216-003-2403-2},
  volume       = {378},
  year         = {2004},
}