Advanced

Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin

Aspholm-Hurtig, Marina; Dailide, Giedrius; Lahmann, Martina; Kalia, Awdhesh; Ilver, Dag; Roche, Niamh LU ; Vikström, Susanne; Sjöström, Rolf; Lindén, Sara LU and Bäckström, Anna, et al. (2004) In Science 305(5683). p.519-522
Abstract
Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group... (More)
Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O–dominant human populations. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science
volume
305
issue
5683
pages
519 - 522
publisher
The American Association for the Advancement of Science
external identifiers
  • pmid:15273394
  • wos:000222828900040
  • scopus:3242748894
ISSN
1095-9203
DOI
10.1126/science.1098801
language
English
LU publication?
yes
id
60462915-6287-463f-9245-e23cd0a07095 (old id 141467)
date added to LUP
2007-07-10 08:51:55
date last changed
2017-10-22 04:31:00
@article{60462915-6287-463f-9245-e23cd0a07095,
  abstract     = {Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O–dominant human populations.},
  author       = {Aspholm-Hurtig, Marina and Dailide, Giedrius and Lahmann, Martina and Kalia, Awdhesh and Ilver, Dag and Roche, Niamh and Vikström, Susanne and Sjöström, Rolf and Lindén, Sara and Bäckström, Anna and Lundberg, Carina and Arnqvist, Anna and Mahdavi, Jafar and Nilsson, Ulf and Velapatiño, Billie and Gilman, Robert H and Gerhard, Markus and Alarcon, Teresa and López-Brea, Manuel and Nakazawa, Teruko and Fox, James G and Correa, Pelayo and Dominguez-Bello, Maria Gloria and Perez-Perez, Guillermo I and Blaser, Martin J and Normark, Staffan and Carlstedt, Ingemar and Oscarson, Stefan and Teneberg, Susann and Berg, Douglas E and Borén, Thomas},
  issn         = {1095-9203},
  language     = {eng},
  number       = {5683},
  pages        = {519--522},
  publisher    = {The American Association for the Advancement of Science},
  series       = {Science},
  title        = {Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin},
  url          = {http://dx.doi.org/10.1126/science.1098801},
  volume       = {305},
  year         = {2004},
}