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Effects of intravenous diazepam and thiopental on the vestibulo-ocular reflex in man

Schalén, L LU ; Korttila, K; Magnusson, M LU ; Padoan, S and Pyykko, Ilmari (1989) In Acta Oto-Laryngologica 108(S468). p.9-165
Abstract

The effects of i.v. injection of diazepam 0.3 mg/kg and thiopental 6.0 mg/kg on vestibulo-ocular reflex (VOR) were studied in 9 healthy volunteers. One hour after injection of both diazepam and thiopental VOR gain was reduced and time constant shortened. Four hours after intravenous injection of diazepam the VOR gain was still significantly reduced and had not yet returned to control 8 h after injection. Although both drugs were detected in blood still 8 h after the injection, there were no longer significant effects on VOR. Moreover, individual values of VOR gain and time constant did not correlate with the blood concentrations of the drugs. Decrease of VOR gain and shortening of time constant after i.v. given diazepam and thiopental... (More)

The effects of i.v. injection of diazepam 0.3 mg/kg and thiopental 6.0 mg/kg on vestibulo-ocular reflex (VOR) were studied in 9 healthy volunteers. One hour after injection of both diazepam and thiopental VOR gain was reduced and time constant shortened. Four hours after intravenous injection of diazepam the VOR gain was still significantly reduced and had not yet returned to control 8 h after injection. Although both drugs were detected in blood still 8 h after the injection, there were no longer significant effects on VOR. Moreover, individual values of VOR gain and time constant did not correlate with the blood concentrations of the drugs. Decrease of VOR gain and shortening of time constant after i.v. given diazepam and thiopental in man are interpreted as resulting from both specific effects on VOR and non-specific reduction of alertness.

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organization
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Contribution to journal
publication status
published
subject
keywords
Adult, Diazepam, Female, Humans, Infusions, Intravenous, Male, Reflex, Vestibulo-Ocular, Thiopental, Time Factors, Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial
in
Acta Oto-Laryngologica
volume
108
issue
S468
pages
9 - 165
publisher
Taylor & Francis
external identifiers
  • scopus:0024782740
ISSN
1651-2251
DOI
10.3109/00016488909139039
language
English
LU publication?
yes
id
1414daaa-c22b-4375-be31-27fdf864dbfc
date added to LUP
2017-05-03 12:58:28
date last changed
2017-05-16 10:08:38
@article{1414daaa-c22b-4375-be31-27fdf864dbfc,
  abstract     = {<p>The effects of i.v. injection of diazepam 0.3 mg/kg and thiopental 6.0 mg/kg on vestibulo-ocular reflex (VOR) were studied in 9 healthy volunteers. One hour after injection of both diazepam and thiopental VOR gain was reduced and time constant shortened. Four hours after intravenous injection of diazepam the VOR gain was still significantly reduced and had not yet returned to control 8 h after injection. Although both drugs were detected in blood still 8 h after the injection, there were no longer significant effects on VOR. Moreover, individual values of VOR gain and time constant did not correlate with the blood concentrations of the drugs. Decrease of VOR gain and shortening of time constant after i.v. given diazepam and thiopental in man are interpreted as resulting from both specific effects on VOR and non-specific reduction of alertness.</p>},
  author       = {Schalén, L and Korttila, K and Magnusson, M and Padoan, S and Pyykko, Ilmari},
  issn         = {1651-2251},
  keyword      = {Adult,Diazepam,Female,Humans,Infusions, Intravenous,Male,Reflex, Vestibulo-Ocular,Thiopental,Time Factors,Clinical Trial,Controlled Clinical Trial,Journal Article,Randomized Controlled Trial},
  language     = {eng},
  number       = {S468},
  pages        = {9--165},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {Effects of intravenous diazepam and thiopental on the vestibulo-ocular reflex in man},
  url          = {http://dx.doi.org/10.3109/00016488909139039},
  volume       = {108},
  year         = {1989},
}