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Synaptic Integration in Cerebellar Granule Cells

Ekerot, Carl-Fredrik LU and Jörntell, Henrik LU (2008) In Cerebellum 7(4). p.539-541
Abstract
To understand the function of cerebellar granule cells, we need detailed knowledge about the information carried by their afferent mossy fibers and how this information is integrated by the granule cells. Recently, we made whole cell recordings from granule cells in the non-anesthetized, decerebrate cats. All recordings were made in the forelimb area of the C3 zone for which the afferent and efferent connections and functional organization have been investigated in detail. Major findings of the study were that the mossy fiber input to single granule cells was modality- and receptive field-specific and that simultaneous activity in two and usually more of the afferent mossy fibers were required to activate the granule cell spike. The high... (More)
To understand the function of cerebellar granule cells, we need detailed knowledge about the information carried by their afferent mossy fibers and how this information is integrated by the granule cells. Recently, we made whole cell recordings from granule cells in the non-anesthetized, decerebrate cats. All recordings were made in the forelimb area of the C3 zone for which the afferent and efferent connections and functional organization have been investigated in detail. Major findings of the study were that the mossy fiber input to single granule cells was modality- and receptive field-specific and that simultaneous activity in two and usually more of the afferent mossy fibers were required to activate the granule cell spike. The high threshold for action potentials and the convergence of afferents with virtually identical information suggest that an important function of granule cells is to increase the signal-to-noise ratio of the mossy fiber-parallel fiber information. Thus a high-sensitivity, noisy mossy fiber input is transformed by the granule cell to a high-sensitivity, low-noise signal. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
FIBER RECEPTIVE-FIELDS, Mossy fibers, Granule cells, Sensory, INTERNEURONS, INFORMATION, PURKINJE-CELLS
in
Cerebellum
volume
7
issue
4
pages
539 - 541
publisher
Informa Healthcare
external identifiers
  • wos:000261792600006
  • scopus:58149095898
ISSN
1473-4230
DOI
10.1007/s12311-008-0064-6
language
English
LU publication?
yes
id
d36852ef-a95b-4338-a1b1-bcaeae2a9a06 (old id 1415718)
date added to LUP
2009-06-16 16:51:43
date last changed
2017-03-26 03:32:43
@article{d36852ef-a95b-4338-a1b1-bcaeae2a9a06,
  abstract     = {To understand the function of cerebellar granule cells, we need detailed knowledge about the information carried by their afferent mossy fibers and how this information is integrated by the granule cells. Recently, we made whole cell recordings from granule cells in the non-anesthetized, decerebrate cats. All recordings were made in the forelimb area of the C3 zone for which the afferent and efferent connections and functional organization have been investigated in detail. Major findings of the study were that the mossy fiber input to single granule cells was modality- and receptive field-specific and that simultaneous activity in two and usually more of the afferent mossy fibers were required to activate the granule cell spike. The high threshold for action potentials and the convergence of afferents with virtually identical information suggest that an important function of granule cells is to increase the signal-to-noise ratio of the mossy fiber-parallel fiber information. Thus a high-sensitivity, noisy mossy fiber input is transformed by the granule cell to a high-sensitivity, low-noise signal.},
  author       = {Ekerot, Carl-Fredrik and Jörntell, Henrik},
  issn         = {1473-4230},
  keyword      = {FIBER RECEPTIVE-FIELDS,Mossy fibers,Granule cells,Sensory,INTERNEURONS,INFORMATION,PURKINJE-CELLS},
  language     = {eng},
  number       = {4},
  pages        = {539--541},
  publisher    = {Informa Healthcare},
  series       = {Cerebellum},
  title        = {Synaptic Integration in Cerebellar Granule Cells},
  url          = {http://dx.doi.org/10.1007/s12311-008-0064-6},
  volume       = {7},
  year         = {2008},
}