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Uterine artery embolization in a sheep model : biodegradable versus non-degradable microspheres

Keussen, Inger LU ; Bengtsson, Johan LU ; Gavier-Widén, Dolores and Karlstam, Erika (2018) In Acta Radiologica 59(10). p.1210-1217
Abstract

Background: Transarterial embolization with particles is a relatively common treatment method in both malignant and benign disorders. Permanent occlusion of the uterine arteries may sometimes be disadvantageous. Purpose: To compare the local tissue effects, possible side effects, and extent of recanalization following uterine artery embolization, using either degradable or non-degradable microspheres in a sheep model. Material and Methods: In 22 female sheep, the uterine artery (UA) was unilaterally, superselectively embolized, with either degradable starch microspheres-DSM (group A) or calibrated gelatin coated spherical shape tris-acryl microspheres-TGMS (group B). The completion of embolization was confirmed by angiography. The... (More)

Background: Transarterial embolization with particles is a relatively common treatment method in both malignant and benign disorders. Permanent occlusion of the uterine arteries may sometimes be disadvantageous. Purpose: To compare the local tissue effects, possible side effects, and extent of recanalization following uterine artery embolization, using either degradable or non-degradable microspheres in a sheep model. Material and Methods: In 22 female sheep, the uterine artery (UA) was unilaterally, superselectively embolized, with either degradable starch microspheres-DSM (group A) or calibrated gelatin coated spherical shape tris-acryl microspheres-TGMS (group B). The completion of embolization was confirmed by angiography. The animals were kept in the animal research facilities for 14 days and sacrificed following new angiographic evaluation. Gross and histological examination of the uterus and other organs was performed. Results: The procedure was successful in all animals. At final angiographic evaluation recanalization was found in 82% of the ewes in group A and in 18% in group B. At histopathological examination, tissue impairment was similar in both groups, whereas vascular changes were more pronounced in the TGMS-group. Conclusion: Embolization with DSM was associated with significantly higher degree of recanalization, than after embolization with TGMS.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
experimental study, Microspheres, uterine artery embolization, uterus
in
Acta Radiologica
volume
59
issue
10
pages
1210 - 1217
publisher
John Wiley & Sons
external identifiers
  • scopus:85044277599
ISSN
0284-1851
DOI
10.1177/0284185118757575
language
English
LU publication?
yes
id
14173534-0c20-42b1-8c22-7e075691e8ed
date added to LUP
2018-04-09 14:14:06
date last changed
2019-08-14 04:13:49
@article{14173534-0c20-42b1-8c22-7e075691e8ed,
  abstract     = {<p>Background: Transarterial embolization with particles is a relatively common treatment method in both malignant and benign disorders. Permanent occlusion of the uterine arteries may sometimes be disadvantageous. Purpose: To compare the local tissue effects, possible side effects, and extent of recanalization following uterine artery embolization, using either degradable or non-degradable microspheres in a sheep model. Material and Methods: In 22 female sheep, the uterine artery (UA) was unilaterally, superselectively embolized, with either degradable starch microspheres-DSM (group A) or calibrated gelatin coated spherical shape tris-acryl microspheres-TGMS (group B). The completion of embolization was confirmed by angiography. The animals were kept in the animal research facilities for 14 days and sacrificed following new angiographic evaluation. Gross and histological examination of the uterus and other organs was performed. Results: The procedure was successful in all animals. At final angiographic evaluation recanalization was found in 82% of the ewes in group A and in 18% in group B. At histopathological examination, tissue impairment was similar in both groups, whereas vascular changes were more pronounced in the TGMS-group. Conclusion: Embolization with DSM was associated with significantly higher degree of recanalization, than after embolization with TGMS.</p>},
  author       = {Keussen, Inger and Bengtsson, Johan and Gavier-Widén, Dolores and Karlstam, Erika},
  issn         = {0284-1851},
  keyword      = {experimental study,Microspheres,uterine artery embolization,uterus},
  language     = {eng},
  month        = {02},
  number       = {10},
  pages        = {1210--1217},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Uterine artery embolization in a sheep model : biodegradable versus non-degradable microspheres},
  url          = {http://dx.doi.org/10.1177/0284185118757575},
  volume       = {59},
  year         = {2018},
}