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High-throughput proteomics using antibody microarrays

Wingren, Christer LU and Borrebaeck, Carl LU (2004) In Espert Review of Proteomics 1(3). p.355-364
Abstract
Antibody-based microarrays are a novel technology that hold great promise in proteomics. Microarrays can be printed with thousands of recombinant antibodies carrying the desired specificities, the biologic sample (e.g., an entire proteome) and any specifically bound analytes detected. The microarray patterns that are generated can then be converted into proteomic maps, or molecular fingerprints, revealing the composition of the proteome. Using this tool, global proteome analysis and protein expression profiling will thus provide new opportunities for biomarker discovery, drug target identification and disease diagnostics, as well as providing insights into disease biology. Intense work is currently underway to develop this novel technology... (More)
Antibody-based microarrays are a novel technology that hold great promise in proteomics. Microarrays can be printed with thousands of recombinant antibodies carrying the desired specificities, the biologic sample (e.g., an entire proteome) and any specifically bound analytes detected. The microarray patterns that are generated can then be converted into proteomic maps, or molecular fingerprints, revealing the composition of the proteome. Using this tool, global proteome analysis and protein expression profiling will thus provide new opportunities for biomarker discovery, drug target identification and disease diagnostics, as well as providing insights into disease biology. Intense work is currently underway to develop this novel technology platform into the high-throughput proteomic tool required by the research community. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Espert Review of Proteomics
volume
1
issue
3
pages
355 - 364
publisher
Future Drugs Ltd
external identifiers
  • wos:000230114400016
  • pmid:15966831
  • scopus:19444381184
ISSN
1744-8387
DOI
10.1586/14789450.1.3.355
language
English
LU publication?
yes
id
b9b8bba7-714b-4165-bdf1-3337acff9937 (old id 141773)
date added to LUP
2007-07-11 11:00:46
date last changed
2017-07-23 03:38:56
@article{b9b8bba7-714b-4165-bdf1-3337acff9937,
  abstract     = {Antibody-based microarrays are a novel technology that hold great promise in proteomics. Microarrays can be printed with thousands of recombinant antibodies carrying the desired specificities, the biologic sample (e.g., an entire proteome) and any specifically bound analytes detected. The microarray patterns that are generated can then be converted into proteomic maps, or molecular fingerprints, revealing the composition of the proteome. Using this tool, global proteome analysis and protein expression profiling will thus provide new opportunities for biomarker discovery, drug target identification and disease diagnostics, as well as providing insights into disease biology. Intense work is currently underway to develop this novel technology platform into the high-throughput proteomic tool required by the research community.},
  author       = {Wingren, Christer and Borrebaeck, Carl},
  issn         = {1744-8387},
  language     = {eng},
  number       = {3},
  pages        = {355--364},
  publisher    = {Future Drugs Ltd},
  series       = {Espert Review of Proteomics},
  title        = {High-throughput proteomics using antibody microarrays},
  url          = {http://dx.doi.org/10.1586/14789450.1.3.355},
  volume       = {1},
  year         = {2004},
}