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Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L

Viau, Muriel; Longo, Nancy S; Lipsky, Peter E; Björck, Lars LU and Zouali, Moncef (2004) In Infection and Immunity 72(6). p.3515-3523
Abstract
Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions on human B-cell numbers and function are largely unknown. Using transgenic mice expressing fully human immunoglobulins, we studied the consequences of in vivo exposure of protein L of Peptostreptococcus magnus with human immunoglobulins. In the mature pool of B cells, protein L exposure resulted in a specific reduction of splenic marginal-zone B cells and peritoneal B-1 cells. Splenic B cells exhibited a skewed light-chain repertoire consistent... (More)
Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions on human B-cell numbers and function are largely unknown. Using transgenic mice expressing fully human immunoglobulins, we studied the consequences of in vivo exposure of protein L of Peptostreptococcus magnus with human immunoglobulins. In the mature pool of B cells, protein L exposure resulted in a specific reduction of splenic marginal-zone B cells and peritoneal B-1 cells. Splenic B cells exhibited a skewed light-chain repertoire consistent with the capacity of protein L to bind specific kappa gene products. Remarkably, these two B-cell subsets are implicated in innate B-cell immunity, allowing rapid clearance of pathogens. Thus, the present study reveals a novel mechanism that may be used by some infectious agents to subvert a first line of the host's immune defense. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection and Immunity
volume
72
issue
6
pages
3515 - 3523
publisher
American Society for Microbiology
external identifiers
  • wos:000221662400051
  • pmid:15155659
  • scopus:2542562891
ISSN
1098-5522
DOI
10.1128/IAI.72.6.3515-3523.2004
language
English
LU publication?
yes
id
741350e1-6841-4e3b-b148-4f26f1daddc1 (old id 141861)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15155659&query_hl=61
date added to LUP
2007-07-05 10:33:18
date last changed
2017-01-01 04:29:18
@article{741350e1-6841-4e3b-b148-4f26f1daddc1,
  abstract     = {Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions on human B-cell numbers and function are largely unknown. Using transgenic mice expressing fully human immunoglobulins, we studied the consequences of in vivo exposure of protein L of Peptostreptococcus magnus with human immunoglobulins. In the mature pool of B cells, protein L exposure resulted in a specific reduction of splenic marginal-zone B cells and peritoneal B-1 cells. Splenic B cells exhibited a skewed light-chain repertoire consistent with the capacity of protein L to bind specific kappa gene products. Remarkably, these two B-cell subsets are implicated in innate B-cell immunity, allowing rapid clearance of pathogens. Thus, the present study reveals a novel mechanism that may be used by some infectious agents to subvert a first line of the host's immune defense.},
  author       = {Viau, Muriel and Longo, Nancy S and Lipsky, Peter E and Björck, Lars and Zouali, Moncef},
  issn         = {1098-5522},
  language     = {eng},
  number       = {6},
  pages        = {3515--3523},
  publisher    = {American Society for Microbiology},
  series       = {Infection and Immunity},
  title        = {Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L},
  url          = {http://dx.doi.org/10.1128/IAI.72.6.3515-3523.2004},
  volume       = {72},
  year         = {2004},
}