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Prevalence of Helicobacter pylori vacA and cagA genotypes in Ethiopian dyspeptic patients

Asrat, Daniel; Nilsson, Ingrid LU ; Mengistu, Yohannes; Kassa, Endale; Ashenafi, Senait; Ayenew, Kiros; Wadström, Torkel LU and Abu Al-Soud, Waleed LU (2004) In Journal of Clinical Microbiology 42(6). p.2682-2684
Abstract
A total of 300 gastric biopsy samples and 50 Helicobacter pylori isolates were collected from Ethiopian adult dyspeptic patients. The vacA and cagA genes were detected in 90 and 79% of biopsy specimens, respectively, and in 100 and 87% of clinical isolates, respectively. Both genes were detected in 84% of the gastric biopsy samples and in 87% of the clinical isolates. Among vacA genotypes, the s1/m1 genotype was the most common in gastric biopsy samples (48%). The vacA and cagA positive H. pylori strains were detected to a higher degree in patients with chronic active gastritis (71%) than patients with other histopathological findings (29%) (P < 0.05).
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Microbiology
volume
42
issue
6
pages
2682 - 2684
publisher
American Society for Microbiology
external identifiers
  • pmid:15184452
  • wos:000222015800048
  • scopus:2942618694
ISSN
1098-660X
DOI
10.1128/JCM.42.6.2682-2684.2004
language
English
LU publication?
yes
id
64ec5a5a-dc82-4d35-b3b5-78cfb24672c5 (old id 141884)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15184452&query_hl=43
date added to LUP
2007-07-09 15:21:56
date last changed
2017-02-12 04:08:52
@article{64ec5a5a-dc82-4d35-b3b5-78cfb24672c5,
  abstract     = {A total of 300 gastric biopsy samples and 50 Helicobacter pylori isolates were collected from Ethiopian adult dyspeptic patients. The vacA and cagA genes were detected in 90 and 79% of biopsy specimens, respectively, and in 100 and 87% of clinical isolates, respectively. Both genes were detected in 84% of the gastric biopsy samples and in 87% of the clinical isolates. Among vacA genotypes, the s1/m1 genotype was the most common in gastric biopsy samples (48%). The vacA and cagA positive H. pylori strains were detected to a higher degree in patients with chronic active gastritis (71%) than patients with other histopathological findings (29%) (P &lt; 0.05).},
  author       = {Asrat, Daniel and Nilsson, Ingrid and Mengistu, Yohannes and Kassa, Endale and Ashenafi, Senait and Ayenew, Kiros and Wadström, Torkel and Abu Al-Soud, Waleed},
  issn         = {1098-660X},
  language     = {eng},
  number       = {6},
  pages        = {2682--2684},
  publisher    = {American Society for Microbiology},
  series       = {Journal of Clinical Microbiology},
  title        = {Prevalence of Helicobacter pylori vacA and cagA genotypes in Ethiopian dyspeptic patients},
  url          = {http://dx.doi.org/10.1128/JCM.42.6.2682-2684.2004},
  volume       = {42},
  year         = {2004},
}