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Structural changes in the developing retina maintained in vitro.

Johansson, Kjell LU and Ehinger, Berndt LU (2005) In Vision Research 45(25-26). p.3235-3243
Abstract
The present study examined the emergence of structural remodeling in explanted neonatal rat retina. Immunohistochemical analysis demonstrated signs of glial and neuronal remodeling after I I days in vitro and included the activation of Muller cells, the formation of ectopic neuropil areas and sprouting of photoreceptor terminals. We also observed that cholinergic and GABA-ergic amacrine cells displayed signs of disorganized laminations. These results demonstrate that retinal culturing initiates structural changes that show morphological similarities to glial and neuronal remodeling identified in retinitis pigmentosa retinas and experimentally detached retinas.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Muller cells, photoreceptor sprouting, in vitro, retina, remodeling
in
Vision Research
volume
45
issue
25-26
pages
3235 - 3243
publisher
Elsevier
external identifiers
  • wos:000233350000014
  • pmid:16024061
  • scopus:27444438653
ISSN
1878-5646
DOI
10.1016/j.visres.2005.05.022
language
English
LU publication?
yes
id
506cd131-8bd7-45b1-a46b-ecd34404f9c3 (old id 142104)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16024061&dopt=Abstract
date added to LUP
2007-07-16 09:30:20
date last changed
2017-01-01 04:54:14
@article{506cd131-8bd7-45b1-a46b-ecd34404f9c3,
  abstract     = {The present study examined the emergence of structural remodeling in explanted neonatal rat retina. Immunohistochemical analysis demonstrated signs of glial and neuronal remodeling after I I days in vitro and included the activation of Muller cells, the formation of ectopic neuropil areas and sprouting of photoreceptor terminals. We also observed that cholinergic and GABA-ergic amacrine cells displayed signs of disorganized laminations. These results demonstrate that retinal culturing initiates structural changes that show morphological similarities to glial and neuronal remodeling identified in retinitis pigmentosa retinas and experimentally detached retinas.},
  author       = {Johansson, Kjell and Ehinger, Berndt},
  issn         = {1878-5646},
  keyword      = {Muller cells,photoreceptor sprouting,in vitro,retina,remodeling},
  language     = {eng},
  number       = {25-26},
  pages        = {3235--3243},
  publisher    = {Elsevier},
  series       = {Vision Research},
  title        = {Structural changes in the developing retina maintained in vitro.},
  url          = {http://dx.doi.org/10.1016/j.visres.2005.05.022},
  volume       = {45},
  year         = {2005},
}