Cancer risk in hospitalized sarcoidosis patients: a follow-up study in Sweden
(2009) In Annals of Oncology 20(6). p.1121-1126- Abstract
- Background: Sarcoidosis patients show dysregulated immune function, which may be related to subsequent cancer. We examined here the overall and specific cancer risks among Swedish subjects who had been hospitalized for sarcoidosis. Methods: A sarcoidosis research database was created by identifying hospitalized sarcoidosis patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. Standardized incidence ratios (SIRs) were calculated for cancers in sarcoidosis patients compared with subjects without sarcoidosis. Results: A total of 10 037 patients were hospitalized for sarcoidosis during years 1964-2004. Among them 1045 patients developed subsequent cancer, giving an overall SIR of 1.40 and 1.18 for... (More)
- Background: Sarcoidosis patients show dysregulated immune function, which may be related to subsequent cancer. We examined here the overall and specific cancer risks among Swedish subjects who had been hospitalized for sarcoidosis. Methods: A sarcoidosis research database was created by identifying hospitalized sarcoidosis patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. Standardized incidence ratios (SIRs) were calculated for cancers in sarcoidosis patients compared with subjects without sarcoidosis. Results: A total of 10 037 patients were hospitalized for sarcoidosis during years 1964-2004. Among them 1045 patients developed subsequent cancer, giving an overall SIR of 1.40 and 1.18 for cancer diagnosed later than 1 year of follow-up. A significant excess was noted for skin (squamous cell), kidney and nonthyroid endocrine tumors and additionally for non-Hodgkin's lymphoma and leukemia. Patients with multiple hospitalizations showed high risks. Conclusions: A 40% overall excess incidence of cancer was noted among sarcoidosis patients, but the increase was confined mainly to the first year after hospitalization. However, the increased risks of skin cancer and non-Hodgkin's lymphoma and leukemia, especially for those with multiple hospitalizations or hospitalized at old age, call for clinical attention. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1425420
- author
- Ji, J. LU ; Shu, X. ; Li, X. ; Sundquist, Kristina LU ; Sundquist, J. and Hemminki, K.
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- sarcoidosis, cancer, national databases
- in
- Annals of Oncology
- volume
- 20
- issue
- 6
- pages
- 1121 - 1126
- publisher
- Oxford University Press
- external identifiers
-
- wos:000266343900024
- scopus:66149146272
- pmid:19211624
- ISSN
- 1569-8041
- DOI
- 10.1093/annonc/mdn767
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Psychiatry/Primary Care/Public Health (013240500), Family medicine, psychiatric epidemiology and migration (013240037), Family medicine, cardiovascular epidemiology and lifestyle (013240038)
- id
- e6d9a83b-ffb4-4d6c-96cd-788f81ff0b58 (old id 1425420)
- date added to LUP
- 2016-04-01 14:42:18
- date last changed
- 2024-01-25 05:44:33
@article{e6d9a83b-ffb4-4d6c-96cd-788f81ff0b58, abstract = {{Background: Sarcoidosis patients show dysregulated immune function, which may be related to subsequent cancer. We examined here the overall and specific cancer risks among Swedish subjects who had been hospitalized for sarcoidosis. Methods: A sarcoidosis research database was created by identifying hospitalized sarcoidosis patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. Standardized incidence ratios (SIRs) were calculated for cancers in sarcoidosis patients compared with subjects without sarcoidosis. Results: A total of 10 037 patients were hospitalized for sarcoidosis during years 1964-2004. Among them 1045 patients developed subsequent cancer, giving an overall SIR of 1.40 and 1.18 for cancer diagnosed later than 1 year of follow-up. A significant excess was noted for skin (squamous cell), kidney and nonthyroid endocrine tumors and additionally for non-Hodgkin's lymphoma and leukemia. Patients with multiple hospitalizations showed high risks. Conclusions: A 40% overall excess incidence of cancer was noted among sarcoidosis patients, but the increase was confined mainly to the first year after hospitalization. However, the increased risks of skin cancer and non-Hodgkin's lymphoma and leukemia, especially for those with multiple hospitalizations or hospitalized at old age, call for clinical attention.}}, author = {{Ji, J. and Shu, X. and Li, X. and Sundquist, Kristina and Sundquist, J. and Hemminki, K.}}, issn = {{1569-8041}}, keywords = {{sarcoidosis; cancer; national databases}}, language = {{eng}}, number = {{6}}, pages = {{1121--1126}}, publisher = {{Oxford University Press}}, series = {{Annals of Oncology}}, title = {{Cancer risk in hospitalized sarcoidosis patients: a follow-up study in Sweden}}, url = {{http://dx.doi.org/10.1093/annonc/mdn767}}, doi = {{10.1093/annonc/mdn767}}, volume = {{20}}, year = {{2009}}, }