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Cancer risk in hospitalized sarcoidosis patients: a follow-up study in Sweden

Ji, J.; Shu, X.; Li, X.; Sundquist, Kristina LU ; Sundquist, J. and Hemminki, K. (2009) In Annals of Oncology 20(6). p.1121-1126
Abstract
Background: Sarcoidosis patients show dysregulated immune function, which may be related to subsequent cancer. We examined here the overall and specific cancer risks among Swedish subjects who had been hospitalized for sarcoidosis. Methods: A sarcoidosis research database was created by identifying hospitalized sarcoidosis patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. Standardized incidence ratios (SIRs) were calculated for cancers in sarcoidosis patients compared with subjects without sarcoidosis. Results: A total of 10 037 patients were hospitalized for sarcoidosis during years 1964-2004. Among them 1045 patients developed subsequent cancer, giving an overall SIR of 1.40 and 1.18 for... (More)
Background: Sarcoidosis patients show dysregulated immune function, which may be related to subsequent cancer. We examined here the overall and specific cancer risks among Swedish subjects who had been hospitalized for sarcoidosis. Methods: A sarcoidosis research database was created by identifying hospitalized sarcoidosis patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. Standardized incidence ratios (SIRs) were calculated for cancers in sarcoidosis patients compared with subjects without sarcoidosis. Results: A total of 10 037 patients were hospitalized for sarcoidosis during years 1964-2004. Among them 1045 patients developed subsequent cancer, giving an overall SIR of 1.40 and 1.18 for cancer diagnosed later than 1 year of follow-up. A significant excess was noted for skin (squamous cell), kidney and nonthyroid endocrine tumors and additionally for non-Hodgkin's lymphoma and leukemia. Patients with multiple hospitalizations showed high risks. Conclusions: A 40% overall excess incidence of cancer was noted among sarcoidosis patients, but the increase was confined mainly to the first year after hospitalization. However, the increased risks of skin cancer and non-Hodgkin's lymphoma and leukemia, especially for those with multiple hospitalizations or hospitalized at old age, call for clinical attention. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sarcoidosis, cancer, national databases
in
Annals of Oncology
volume
20
issue
6
pages
1121 - 1126
publisher
Oxford University Press
external identifiers
  • wos:000266343900024
  • scopus:66149146272
ISSN
1569-8041
DOI
10.1093/annonc/mdn767
language
English
LU publication?
yes
id
e6d9a83b-ffb4-4d6c-96cd-788f81ff0b58 (old id 1425420)
date added to LUP
2009-07-02 16:12:13
date last changed
2017-09-10 04:18:13
@article{e6d9a83b-ffb4-4d6c-96cd-788f81ff0b58,
  abstract     = {Background: Sarcoidosis patients show dysregulated immune function, which may be related to subsequent cancer. We examined here the overall and specific cancer risks among Swedish subjects who had been hospitalized for sarcoidosis. Methods: A sarcoidosis research database was created by identifying hospitalized sarcoidosis patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. Standardized incidence ratios (SIRs) were calculated for cancers in sarcoidosis patients compared with subjects without sarcoidosis. Results: A total of 10 037 patients were hospitalized for sarcoidosis during years 1964-2004. Among them 1045 patients developed subsequent cancer, giving an overall SIR of 1.40 and 1.18 for cancer diagnosed later than 1 year of follow-up. A significant excess was noted for skin (squamous cell), kidney and nonthyroid endocrine tumors and additionally for non-Hodgkin's lymphoma and leukemia. Patients with multiple hospitalizations showed high risks. Conclusions: A 40% overall excess incidence of cancer was noted among sarcoidosis patients, but the increase was confined mainly to the first year after hospitalization. However, the increased risks of skin cancer and non-Hodgkin's lymphoma and leukemia, especially for those with multiple hospitalizations or hospitalized at old age, call for clinical attention.},
  author       = {Ji, J. and Shu, X. and Li, X. and Sundquist, Kristina and Sundquist, J. and Hemminki, K.},
  issn         = {1569-8041},
  keyword      = {sarcoidosis,cancer,national databases},
  language     = {eng},
  number       = {6},
  pages        = {1121--1126},
  publisher    = {Oxford University Press},
  series       = {Annals of Oncology},
  title        = {Cancer risk in hospitalized sarcoidosis patients: a follow-up study in Sweden},
  url          = {http://dx.doi.org/10.1093/annonc/mdn767},
  volume       = {20},
  year         = {2009},
}