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Stem Cell States, Fates, and the Rules of Attraction

Enver, Tariq; Pera, Martin; Peterson, Carsten LU and Andrews, Peter W. (2009) In Cell Stem Cell 4(5). p.387-397
Abstract
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. The nature of the stem cell substates and their relationship to commitment to differentiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell Stem Cell
volume
4
issue
5
pages
387 - 397
publisher
Cell Press
external identifiers
  • wos:000266071100008
  • scopus:65349097905
ISSN
1934-5909
DOI
10.1016/j.stem.2009.04.011
language
English
LU publication?
yes
id
4cf22367-9426-4a89-8068-4bc1ffe2730b (old id 1426240)
date added to LUP
2009-06-30 11:35:29
date last changed
2017-11-12 03:27:32
@article{4cf22367-9426-4a89-8068-4bc1ffe2730b,
  abstract     = {Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. The nature of the stem cell substates and their relationship to commitment to differentiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors.},
  author       = {Enver, Tariq and Pera, Martin and Peterson, Carsten and Andrews, Peter W.},
  issn         = {1934-5909},
  language     = {eng},
  number       = {5},
  pages        = {387--397},
  publisher    = {Cell Press},
  series       = {Cell Stem Cell},
  title        = {Stem Cell States, Fates, and the Rules of Attraction},
  url          = {http://dx.doi.org/10.1016/j.stem.2009.04.011},
  volume       = {4},
  year         = {2009},
}